Perakine reductase

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Perakine reductase
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EC no. 1.1.1.317
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Perakine reductase (EC 1.1.1.317) is an enzyme with systematic name raucaffrinoline:NADP+ oxidoreductase. [1] [2] This enzyme catalyses the following chemical reaction

raucaffrinoline + NADP+ perakine + NADPH + H+

The biosynthesis of raucaffrinoline from perakine is a side route of the ajmaline biosynthesis pathway.

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References

  1. ↑ Sun L, Ruppert M, Sheludko Y, Warzecha H, Zhao Y, Stöckigt J (July 2008). "Purification, cloning, functional expression and characterization of perakine reductase: the first example from the AKR enzyme family, extending the alkaloidal network of the plant Rauvolfia". Plant Molecular Biology. 67 (5): 455–67. doi:10.1007/s11103-008-9331-7. PMID   18409028.
  2. ↑ Rosenthal C, Mueller U, Panjikar S, Sun L, Ruppert M, Zhao Y, Stöckigt J (December 2006). "Expression, purification, crystallization and preliminary X-ray analysis of perakine reductase, a new member of the aldo-keto reductase enzyme superfamily from higher plants". Acta Crystallographica Section F. 62 (Pt 12): 1286–9. doi:10.1107/S174430910605041X. PMC   2225361 . PMID   17142919.
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