Perakine reductase

Perakine reductase
Identifiers
EC no.	1.1.1.317
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
Search PMC articles PubMed articles NCBI proteins

Perakine reductase (EC 1.1.1.317) is an enzyme with systematic name raucaffrinoline:NADP⁺ oxidoreductase. ^{[1] [2]} This enzyme catalyses the following chemical reaction

raucaffrinoline + NADP⁺${\displaystyle \rightleftharpoons }$ perakine + NADPH + H⁺

The biosynthesis of raucaffrinoline from perakine is a side route of the ajmaline biosynthesis pathway.

References

1. Sun L, Ruppert M, Sheludko Y, Warzecha H, Zhao Y, Stöckigt J (July 2008). "Purification, cloning, functional expression and characterization of perakine reductase: the first example from the AKR enzyme family, extending the alkaloidal network of the plant Rauvolfia". Plant Molecular Biology. 67 (5): 455–67. Bibcode:2008PMolB..67..455S. doi:10.1007/s11103-008-9331-7. PMID   18409028.
2. Rosenthal C, Mueller U, Panjikar S, Sun L, Ruppert M, Zhao Y, Stöckigt J (December 2006). "Expression, purification, crystallization and preliminary X-ray analysis of perakine reductase, a new member of the aldo-keto reductase enzyme superfamily from higher plants". Acta Crystallographica Section F. 62 (Pt 12): 1286–9. doi:10.1107/S174430910605041X. PMC   2225361 . PMID   17142919.

External links

• Perakine+reductase at the U.S. National Library of Medicine Medical Subject Headings (MeSH)