STEAP3

STEAP3
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2VNS, 2VQ3
Identifiers
Aliases	STEAP3 , AHMIO2, STMP3, TSAP6, dudlin-2, dudulin-2, pHyde, STEAP3 metalloreductase
External IDs	OMIM: 609671 MGI: 1915678 HomoloGene: 10084 GeneCards: STEAP3
Gene location (Human) Chr. Chromosome 2 (human) [1] Band 2q14.2 Start 119,223,831 bp [1] End 119,265,652 bp [1]
Gene location (Mouse) Chr. Chromosome 1 (mouse) [2] Band 1|1 E2.3 Start 120,118,487 bp [2] End 120,200,435 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in right lobe of liver spinal ganglia bronchial epithelial cell lactiferous duct trigeminal ganglion triceps brachii muscle biceps brachii thoracic diaphragm vastus lateralis muscle parotid gland Top expressed in lip aortic valve dermal bone ascending aorta morula mandible esophagus maxilla skeletal muscle tissue yolk sac More reference expression data BioGPS More reference expression data
Gene ontology Molecular function oxidoreductase activity protein binding ferric-chelate reductase (NADPH) activity metal ion binding cupric reductase activity oxidoreductase activity, acting on metal ions, NAD or NADP as acceptor identical protein binding Cellular component integral component of membrane multivesicular body endosome endosome membrane membrane integral component of plasma membrane cytoplasm plasma membrane Biological process apoptotic process protein secretion cell cycle iron ion homeostasis copper ion import ion transport transferrin transport regulation of apoptotic process iron ion import across cell outer membrane Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 55240 68428 Ensembl ENSG00000115107 ENSMUSG00000026389 UniProt Q658P3 Q8CI59 RefSeq (mRNA) NM_001008410 NM_018234 NM_138637 NM_182915 NM_001085409 NM_133186 NM_001379354 NM_001379355 RefSeq (protein) NP_001008410 NP_060704 NP_619543 NP_878919 NP_001078878 NP_573449 NP_001366283 NP_001366284 Location (UCSC) Chr 2: 119.22 – 119.27 Mb Chr 1: 120.12 – 120.2 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Metalloreductase STEAP3 is an enzyme that in humans is encoded by the STEAP3 gene. ^{[5] [6]}

STEAP3 is a metalloreductase, capable of converting iron from an insoluble ferric (Fe³⁺) to a soluble ferrous (Fe²⁺) form. ^[7]

STEAP3 and other STEAP protein, with the exception of STEAP1, are predicted to contain a Di-nucleotide binding domain (Rossmann Fold). This has been shown using X-ray crystallography in the cases of STEAP3 and STEAP4 (PDB: 2VNS, 2VQ3 and 2YJZ). ^{[8] [9]}

Interactions

STEAP3 has been shown to interact with BNIP3L ^[5] and PKMYT1. ^[5]

References

1. GRCh38: Ensembl release 89: ENSG00000115107 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000026389 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Passer BJ, Nancy-Portebois V, Amzallag N, Prieur S, Cans C, Roborel de Climens A, Fiucci G, Bouvard V, Tuynder M, Susini L, Morchoisne S, Crible V, Lespagnol A, Dausset J, Oren M, Amson R, Telerman A (March 2003). "The p53-inducible TSAP6 gene product regulates apoptosis and the cell cycle and interacts with Nix and the Myt1 kinase". Proceedings of the National Academy of Sciences of the United States of America. 100 (5): 2284–9. Bibcode:2003PNAS..100.2284P. doi: 10.1073/pnas.0530298100 . PMC   151332 . PMID   12606722.
6. "Entrez Gene: STEAP3 STEAP family member 3".
7. Ohgami RS, Campagna DR, McDonald A, Fleming MD (August 2006). "The Steap proteins are metalloreductases". Blood. 108 (4): 1388–94. doi:10.1182/blood-2006-02-003681. PMC   1785011 . PMID   16609065.
8. Sendamarai AK, Ohgami RS, Fleming MD, Lawrence CM (May 2008). "Structure of the membrane proximal oxidoreductase domain of human Steap3, the dominant ferrireductase of the erythroid transferrin cycle" (PDF). Proceedings of the National Academy of Sciences of the United States of America. 105 (21): 7410–5. Bibcode:2008PNAS..105.7410S. doi: 10.1073/pnas.0801318105 . PMC   2396704 . PMID   18495927.
9. Gauss GH, Kleven MD, Sendamarai AK, Fleming MD, Lawrence CM (July 2013). "The crystal structure of six-transmembrane epithelial antigen of the prostate 4 (Steap4), a ferri/cuprireductase, suggests a novel interdomain flavin-binding site". The Journal of Biological Chemistry. 288 (28): 20668–82. doi: 10.1074/jbc.M113.479154 . PMC   3711330 . PMID   23733181.

Further reading

• Hartley JL, Temple GF, Brasch MA (November 2000). "DNA cloning using in vitro site-specific recombination". Genome Research. 10 (11): 1788–95. doi:10.1101/gr.143000. PMC   310948 . PMID   11076863.
• Wiemann S, Weil B, Wellenreuther R, Gassenhuber J, Glassl S, Ansorge W, Böcher M, Blöcker H, Bauersachs S, Blum H, Lauber J, Düsterhöft A, Beyer A, Köhrer K, Strack N, Mewes HW, Ottenwälder B, Obermaier B, Tampe J, Heubner D, Wambutt R, Korn B, Klein M, Poustka A (March 2001). "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs". Genome Research. 11 (3): 422–35. doi:10.1101/gr.GR1547R. PMC   311072 . PMID   11230166.
• Korkmaz KS, Elbi C, Korkmaz CG, Loda M, Hager GL, Saatcioglu F (September 2002). "Molecular cloning and characterization of STAMP1, a highly prostate-specific six transmembrane protein that is overexpressed in prostate cancer". The Journal of Biological Chemistry. 277 (39): 36689–96. doi: 10.1074/jbc.M202414200 . PMID   12095985.
• Amzallag N, Passer BJ, Allanic D, Segura E, Théry C, Goud B, Amson R, Telerman A (October 2004). "TSAP6 facilitates the secretion of translationally controlled tumor protein/histamine-releasing factor via a nonclassical pathway". The Journal of Biological Chemistry. 279 (44): 46104–12. doi: 10.1074/jbc.M404850200 . PMID   15319436.
• Wiemann S, Arlt D, Huber W, Wellenreuther R, Schleeger S, Mehrle A, Bechtel S, Sauermann M, Korf U, Pepperkok R, Sültmann H, Poustka A (October 2004). "From ORFeome to biology: a functional genomics pipeline". Genome Research. 14 (10B): 2136–44. doi:10.1101/gr.2576704. PMC   528930 . PMID   15489336.
• Mehrle A, Rosenfelder H, Schupp I, del Val C, Arlt D, Hahne F, Bechtel S, Simpson J, Hofmann O, Hide W, Glatting KH, Huber W, Pepperkok R, Poustka A, Wiemann S (January 2006). "The LIFEdb database in 2006". Nucleic Acids Research. 34 (Database issue): D415-8. doi:10.1093/nar/gkj139. PMC   1347501 . PMID   16381901.