Sulfadoxine

Sulfadoxine

Clinical data
AHFS/Drugs.com	International Drug Names
ATCvet code	QJ01EQ13 ( WHO )
Identifiers
IUPAC name 4-Amino-N-(5,6-dimethoxy-4-pyrimidinyl)benzenesulfonamide
CAS Number	2447-57-6  Y
PubChem CID	17134
DrugBank	DB01299  N
ChemSpider	16218  N
UNII	88463U4SM5
KEGG	D00580  Y
ChEMBL	ChEMBL1539  N
NIAID ChemDB	007816
CompTox Dashboard (EPA)	DTXSID6023608
ECHA InfoCard	100.017.732
Chemical and physical data
Formula	C12H14N4O4S
Molar mass	310.33 g·mol−1
3D model (JSmol)	Interactive image
Melting point	190 to 194 °C (374 to 381 °F)
SMILES COC1=C(N=CN=C1OC)NS(=O)(=O)C2=CC=C(C=C2)N
NY  (what is this?)    (verify)

Sulfadoxine (also spelled sulphadoxine) is an ultra-long-lasting sulfonamide used in combination with pyrimethamine to treat malaria. ^[1]

It is also used to prevent malaria ^[2] but due to high levels of sulphadoxine-pyrimethamine resistance, this use has become less common. ^[3]

It is also used, usually in combination with other drugs, to treat or prevent various infections in livestock.^{[ citation needed ]}

Mechanism of action

Sulfadoxine competitively inhibits dihydropteroate synthase, interfering with folate synthesis.^{[ citation needed ]}

See also

• Sulfadoxine/pyrimethamine

References

1. Medical Treatment - Sulphadoxine and Pyrimethamine Archived 2007-12-28 at the Wayback Machine .
2. "WHO | Intermittent preventive treatment in pregnancy (IPTp)". Who.int. Archived from the original on March 5, 2014. Retrieved 27 November 2021.
3. Matondo SI, Temba GS, Kavishe AA, et al. (2014). "High levels of sulphadoxine-pyrimethamine resistance Pfdhfr-Pfdhps quintuple mutations: a cross sectional survey of six regions in Tanzania". Malar J. 13 152. doi: 10.1186/1475-2875-13-152 . PMC   3998221 . PMID   24751352.