Sulfamethoxypyridazine

Sulfamethoxypyridazine
Clinical data
AHFS/Drugs.com	International Drug Names
ATC code	J01ED05 ( WHO ) QJ01EQ15 ( WHO );
Identifiers
	IUPAC name 4-amino-N-(6-methoxypyridazin-3-yl)benzenesulfonamide;
CAS Number	80-35-3 ;
PubChem CID	5330 ;
ChemSpider	5139 ;
UNII	T034E4NS2Z ;
KEGG	D02439 ;
ChEBI	CHEBI:102516 ;
ChEMBL	ChEMBL268869 ;
CompTox Dashboard (EPA)	DTXSID5023611 ;
ECHA InfoCard	100.001.157
Chemical and physical data
Formula	C11H12N4O3S
Molar mass	280.30 g·mol−1
3D model (JSmol)	Interactive image ;
	SMILES O=S(=O)(Nc1nnc(OC)cc1)c2ccc(N)cc2;
	InChI InChI=1S/C11H12N4O3S/c1-18-11-7-6-10(13-14-11)15-19(16,17)9-4-2-8(12)3-5-9/h2-7H,12H2,1H3,(H,13,15) ; Key:VLYWMPOKSSWJAL-UHFFFAOYSA-N ;
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Last updated January 11, 2026

Sulfamethoxypyridazine is a sulfonamide antibacterial.^[1]

It is prescribed for vaginal irritation, and severe acute thrush.

It is also used in the treatment of Dermatitis herpetiformis,^[2] where it is an alternative therapy to Dapsone.

Sulfamethoxypyridazine is supplied as 500mg tablets.

References

↑ Boger WP, Gylfe JM, Strickland CS (November 1956). "Sulfamethoxypyridazine (Kynex), a new long-acting sulfonamide". Antibiotic Medicine & Clinical Therapy. 3 (6). New York, NY: 378–87. PMID 13363378.
↑ Vilanova X, De Moragas JM (October 1959). "[Treatment of dermatitis herpetiformis (Duhring) and herpes gestationis with sulfamethoxypyridazine]". Actas Dermo-sifiliograficas (in Spanish). 50: 439–42. PMID 13842251.

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[pmid13363378-1] Boger WP, Gylfe JM, Strickland CS (November 1956). "Sulfamethoxypyridazine (Kynex), a new long-acting sulfonamide". Antibiotic Medicine & Clinical Therapy. 3 (6). New York, NY: 378–87. PMID 13363378.

[pmid13842251-2] Vilanova X, De Moragas JM (October 1959). "[Treatment of dermatitis herpetiformis (Duhring) and herpes gestationis with sulfamethoxypyridazine]". Actas Dermo-sifiliograficas (in Spanish). 50: 439–42. PMID 13842251.

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