Sulfametrole

Last updated
Sulfametrole
Sulfametrole.svg
Sulfametrole 3D spacefill.png
Clinical data
AHFS/Drugs.com International Drug Names
Routes of
administration 		Oral
ATC code
Legal status
Legal status
  • In general: ℞ (Prescription only)
Identifiers
  • 4-amino-N-(4-methoxy-1,2,5-thiadiazol-3-yl)benzenesulfonamide
CAS Number
PubChem CID
ChemSpider
UNII
KEGG
ChEBI
CompTox Dashboard (EPA)
ECHA InfoCard 100.046.611 OOjs UI icon edit-ltr-progressive.svg
Chemical and physical data
Formula C9H10N4O3S2
Molar mass 286.32 g·mol−1
3D model (JSmol)
  • COc1c(nsn1)NS(=O)(=O)c2ccc(cc2)N
  • InChI=1S/C9H10N4O3S2/c1-16-9-8(11-17-12-9)13-18(14,15)7-4-2-6(10)3-5-7/h2-5H,10H2,1H3,(H,11,13)
  • Key:IZOYMGQQVNAMHS-UHFFFAOYSA-N
   (verify)

Sulfametrole (INN) is a sulfonamide antibacterial.

It can be given with trimethoprim. [1]

Related Research Articles

<span class="mw-page-title-main">Trimethoprim</span> Antibiotic

Trimethoprim (TMP) is an antibiotic used mainly in the treatment of bladder infections. Other uses include for middle ear infections and travelers' diarrhea. With sulfamethoxazole or dapsone it may be used for Pneumocystis pneumonia in people with HIV/AIDS. It is taken orally.

ATC code J01Antibacterials for systemic use is a therapeutic subgroup of the Anatomical Therapeutic Chemical Classification System, a system of alphanumeric codes developed by the World Health Organization (WHO) for the classification of drugs and other medical products. Subgroup J01 is part of the anatomical group J Antiinfectives for systemic use.

<span class="mw-page-title-main">Trimethoprim/sulfamethoxazole</span> Combination of two antibiotic drugs

Trimethoprim/sulfamethoxazole, sold under the brand name Bactrim among others, is a fixed-dose combination antibiotic medication used to treat a variety of bacterial infections. It consists of one part trimethoprim to five parts sulfamethoxazole. It is used to treat urinary tract infections, methicillin-resistant Staphylococcus aureus (MRSA) skin infections, travelers' diarrhea, respiratory tract infections, and cholera, among others. It is used both to treat and prevent pneumocystis pneumonia and toxoplasmosis in people with HIV/AIDS and other causes of immunosuppression. It can be given orally or intravenous infusion.

<span class="mw-page-title-main">Folinic acid</span> Derivative of folic acid used in cancer treatment

Folinic acid, also known as leucovorin, is a medication used to decrease the toxic effects of methotrexate and pyrimethamine. It is also used in combination with 5-fluorouracil to treat colorectal cancer and pancreatic cancer, may be used to treat folate deficiency that results in anemia, and methanol poisoning. It is taken by mouth, injection into a muscle, or injection into a vein.

<span class="mw-page-title-main">Sulfamethoxazole</span> Chemical compound

Sulfamethoxazole is an antibiotic. It is used for bacterial infections such as urinary tract infections, bronchitis, and prostatitis and is effective against both gram negative and positive bacteria such as Escherichia coli and Listeria monocytogenes.

<i>Burkholderia</i> Genus of bacteria

Burkholderia is a genus of Pseudomonadota whose pathogenic members include the Burkholderia cepacia complex, which attacks humans and Burkholderia mallei, responsible for glanders, a disease that occurs mostly in horses and related animals; Burkholderia pseudomallei, causative agent of melioidosis; and Burkholderia cepacia, an important pathogen of pulmonary infections in people with cystic fibrosis (CF). Burkholderia species is also found in marine environments. S.I. Paul et al. (2021) isolated and characterized Burkholderia cepacia from marine sponges of the Saint Martin's Island of the Bay of Bengal, Bangladesh.

<i>Moraxella catarrhalis</i> Species of bacterium

Moraxella catarrhalis is a fastidious, nonmotile, Gram-negative, aerobic, oxidase-positive diplococcus that can cause infections of the respiratory system, middle ear, eye, central nervous system, and joints of humans. It causes the infection of the host cell by sticking to the host cell using trimeric autotransporter adhesins.

<span class="mw-page-title-main">Dihydropteroate</span> Chemical compound

Dihydropteroate is an important intermediate in folate biosynthesis. It is a pterin created from para-aminobenzoic acid (PABA) by the enzyme dihydropteroate synthase.

<span class="mw-page-title-main">Sulfadimidine</span> Chemical compound

Sulfadimidine or sulfamethazine is a sulfonamide antibacterial.

<span class="mw-page-title-main">Brodimoprim</span> Chemical compound

Brodimoprim is a structural derivative of trimethoprim. In brodimoprim, the 4-methoxy group of trimethoprim is replaced with a bromine atom.

<span class="mw-page-title-main">Antifolate</span> Class of antimetabolite medications

Antifolates are a class of antimetabolite medications that antagonise (that is, block) the actions of folic acid (vitamin B9). Folic acid's primary function in the body is as a cofactor to various methyltransferases involved in serine, methionine, thymidine and purine biosynthesis. Consequently, antifolates inhibit cell division, DNA/RNA synthesis and repair and protein synthesis. Some such as proguanil, pyrimethamine and trimethoprim selectively inhibit folate's actions in microbial organisms such as bacteria, protozoa and fungi. The majority of antifolates work by inhibiting dihydrofolate reductase (DHFR).

<span class="mw-page-title-main">Tetroxoprim</span> Chemical compound

Tetroxoprim (INN) is a derivative of trimethoprim. It was first described in 1979.

<span class="mw-page-title-main">Fixed drug reaction</span> Medical condition

Fixed drug reactions are common and so named because they recur at the same site with each exposure to a particular medication. Medications inducing fixed drug eruptions are usually those taken intermittently.

ATCvet code QJ51Antibacterials for intramammary use is a therapeutic subgroup of the Anatomical Therapeutic Chemical Classification System for veterinary medicinal products, a system of alphanumeric codes developed by the World Health Organization (WHO) for the classification of drugs and other medical products for veterinary use. Subgroup QJ51 is part of the anatomical group QJ Antiinfectives for systemic use.

Trimethoprim/sulfadoxine, sold under the brand name Trimidox, is an antibacterial agent that is used in cattle and swine to prevent and treat infections by both gram-negative and gram-positive bacteria.

<span class="mw-page-title-main">New York City agar</span>

The NYC medium or GC medium agar is used for isolating Gonococci.

<span class="mw-page-title-main">Wellcome Research Laboratories</span>

Wellcome Research Laboratories was a site in Beckenham, south-east London, that was a main research centre for pharmaceuticals. Until 1965, this laboratory site was situated in Kent.

Isoniazid/pyridoxine/sulfamethoxazole/trimethoprim (INH/B6/CTX) is a fixed-dose combination medication for the prevention of opportunistic infections in HIV/AIDS. It combines isoniazid, pyridoxine, sulfamethoxazole, and trimethoprim. Specifically it is used to prevent tuberculosis, toxoplasmosis, pneumonia, malaria, and isosporiasis. It is taken by mouth.

Trimethoprim/sulfadiazine (TMP/SDZ) is a combination drug composed of trimethoprim and sulfadiazine used in the treatment of bacterial infections of animals, particularly horses.

References

  1. ↑ Plummer FA, Nsanze H, D'Costa LJ, et al. (July 1983). "Single-dose therapy of chancroid with trimethoprim-sulfametrole". N. Engl. J. Med. 309 (2): 67–71. doi:10.1056/NEJM198307143090202. PMID   6343878.


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