The race was won by Bruce McLaren, his second consecutive victory, having won his first at Sebring at the end of the 1959 season. Stirling Moss suffered a suspension failure while leading, and took over Maurice Trintignant's Cooper, but was not awarded points for third place as a result of the shared drive, a rule that had been in place since 1958.
Three other local drivers took part in the practice sessions for the race. The Scuderia Centro Sud Maserati (№ 10) was driven in the first practice session by Pedro Llano, as well as by eventual race driver Nasif Estéfano and Rodriguez Larreta. In the second practice session, Julio Pola shared Chimeri's № 44 Maserati. Also, Oscar Cabalén shared Estéfano's car in the qualifying session as a reserve driver.
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