Atrolysin B

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Atrolysin B
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EC no. 3.4.24.41
CAS no. 172306-48-8
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Atrolysin B (EC 3.4.24.41, Crotalus atrox metalloendopeptidase b, hemorrhagic toxin b, Ht-b) is an enzyme. [1] [2] This enzyme catalyses the following chemical reaction

Cleavage of His5-Leu, His10-Leu, Ala14-Leu, Tyr16-Leu and Gly23-Phe of insulin B chain; identical to the cleavage of insulin B chain by atrolysin C. Also cleaves -Ser bonds in glucagon

This enzyme is present in the western diamondback rattlesnake ( Crotalus atrox ).

Related Research Articles

<i>Crotalus</i> Genus of snakes

Crotalus is a genus of venomous pit vipers in the family Viperidae, commonly known as rattlesnakes or rattlers. The genus is found only in the Americas from southern Canada to northern Argentina. The generic name Crotalus is derived from the Greek word κρόταλονkrótalοn, which means "rattle" or "castanet", and refers to the rattle on the end of the tail, which makes this group so distinctive. As of July 2023, 44 to 53 species are recognized as being valid.

<span class="mw-page-title-main">Snake venom</span> Highly modified saliva containing zootoxins

Snake venom is a highly toxic saliva containing zootoxins that facilitates in the immobilization and digestion of prey. This also provides defense against threats. Snake venom is injected by unique fangs during a bite, whereas some species are also able to spit venom.

<i>Crotalus scutulatus</i> Species of snake

Crotalus scutulatus is a highly venomous pit viper species found in the deserts of the southwestern United States and central Mexico. It is perhaps best known for its potent neurotoxic-hemotoxic venom, which is considered the world's most potent rattlesnake venom.

<span class="mw-page-title-main">Eastern diamondback rattlesnake</span> Species of reptile endemic to the southeastern US

The eastern diamondback rattlesnake is a species of pit viper in the family Viperidae. The species is endemic to the Southeastern United States. It is one of the heaviest venomous snakes in the Americas and the largest rattlesnake. No subspecies are recognized.

Crotalidae Polyvalent Immune Fab (ovine), sold under the brandname CroFab, is a snake antivenin, indicated for North American Crotalid (Rattlesnake, Copperhead and Cottonmouth/Water moccasin) snake envenomation.

<span class="mw-page-title-main">Western diamondback rattlesnake</span> Species of snake

The western diamondback rattlesnake or Texas diamond-back is a rattlesnake species and member of the viper family, found in the southwestern United States and Mexico. Like all other rattlesnakes and all other vipers, it is venomous. It is likely responsible for the majority of snakebite fatalities in northern Mexico and the greatest number of snakebites in the U.S. No subspecies are currently recognized.

Adamalysin is an enzyme. This enzyme catalyses the following chemical reaction

Atrolysin A is an enzyme that is one of six hemorrhagic toxins found in the venom of western diamondback rattlesnake. This endopeptidase has a length of 419 amino acid residues. The metalloproteinase disintegrin-like domain and the cysteine-rich domain of the enzyme are responsible for the enzyme's hemorrhagic effects on organisms via inhibition of platelet aggregation.

Bothropasin is an enzyme. This enzyme catalyses the following chemical reaction

Atrolysin C is an enzyme. This enzyme catalyses the following chemical reaction

Atroxase is an enzyme. This enzyme catalyses the following chemical reaction

Atrolysin E is an enzyme. This enzyme catalyses the following chemical reaction

Atrolysin F is an enzyme. This enzyme catalyses the following chemical reaction

Horrilysin is an enzyme. This enzyme catalyses the following chemical reaction

Ruberlysin is an enzyme. This enzyme catalyses the following chemical reaction

Trimerelysin I is an enzyme. This enzyme catalyses the following chemical reaction

Trimerelysin II is an enzyme. This enzyme catalyses the following chemical reaction

Mucrolysin is an enzyme. This enzyme catalyses the following chemical reaction

Fibrolase is an enzyme. This enzyme catalyses the following chemical reaction

Jararhagin is an enzyme. This enzyme catalyses the following chemical reaction

References

  1. Bjarnason JB, Tu AT (August 1978). "Hemorrhagic toxins from Western diamondback rattlesnake (Crotalus atrox) venom: isolation and characterization of five toxins and the role of zinc in hemorrhagic toxin e". Biochemistry. 17 (16): 3395–404. doi:10.1021/bi00609a033. PMID   210790.
  2. Bjarnason JB, Hamilton D, Fox JW (May 1988). "Studies on the mechanism of hemorrhage production by five proteolytic hemorrhagic toxins from Crotalus atrox venom". Biological Chemistry Hoppe-Seyler. 369 Suppl: 121–9. PMID   3060135.