Company type | Public |
---|---|
Industry | Biotechnology Chemicals Pharmaceuticals [1] [2] |
Founded | 1904 |
Headquarters | Radnor, Pennsylvania, U.S. |
Key people | Michael Stubblefield (CEO and President) |
Brands |
|
Revenue | US$6.967 billion [3] (2024) |
US$321 million [3] | |
Owner | New Mountain Capital (10%) Funds advised by Goldman Sachs (13%) [4] |
Number of employees | 14,500 (December 2023) [5] |
Website | avantorsciences |
Avantor, Inc. is an American biotechnology, chemicals, and pharmaceuticals company headquartered in Radnor, Pennsylvania. Established in 1904 as J.T. Baker, the company changed its name to Avantor in 2010. Avantor went public in 2019 and is now listed on the New York Stock Exchange under the symbol “AVTR”.
The company's history traces back to 1904, when John Townsend Baker (1860-1935) founded the chemical company J.T. Baker specializing in producing chemically pure reagents. The company gained recognition for its "Baker Analyzed" labels, which provided detailed analyses of trace impurities in its products. In 1911, the company began publishing "The Chemist-Analyst," which promoted its products and philosophy. After Baker's death in 1935, the company was acquired by Vick Chemical Company in 1941. During World War II, J.T. Baker expanded its product line to include penicillin, pesticides, and chemicals for batteries and munitions. After the war, the company further diversified into high-purity solvents, chromatography columns, and hazardous waste spill kits. In 1985, J.T. Baker and its parent company Richardson-Vicks were sold to Procter & Gamble, and subsequently sold to Mallinckrodt in 1995. [6] [7]
In 2010, investment firm New Mountain Capital purchased Mallinckrodt Baker Inc., which then changed its name to Avantor. [8] The company extended its international market with the 2011 acquisitions of the Indian laboratory reagents supplier RFCL and the Polish lab supply firm POCH. [9]
In 2016, Avantor merged with Nusil Technology. In 2017, Avantor acquired chemical blending business Puritan Products Inc. and laboratory supplies company VWR. The combined company operates under the Avantor name, with VWR and vwr.com remaining as a selling channel. [10]
In May 2019, Avantor went public with a $3.8 billion initial public offering, which gave the company a market capitalization of $7.62 billion. [8] As of December 2023, the top shareholders of Avantor included Vanguard Group Inc., Dodge & Cox Inc., T. Rowe Price Investment Management Inc., and BlackRock Inc. [11]
That same year the company expanded further into Asia with the opening of an innovation center in Shanghai, which focuses on monoclonal antibodies and cell and gene therapy. [12] In 2020, Avantor doubled the size of its Bridgewater, New Jersey innovation center, expanding its research and development capabilities and cell and gene therapy reagent manufacturing. [13]
In 2020, Avantor began providing services and raw materials to companies manufacturing vaccines and other therapies to fight the COVID-19 pandemic. Avantor added employees and extra shifts in order to increase capacity for producing synthetic lipids that are formed into nanoparticles, which carry mRNA into human cells. [14]
In June 2021, Avantor acquired China-based RIM Bio, a manufacturer of single-use bioprocess bags and assemblies for biopharmaceutical manufacturing applications. Through the acquisition, Avantor gained access to RIM's Changzhou, China facility, marking Avantor's first single-use production plant in the Africa, Middle East, Asia (AMEA) region. The deal is part of a larger expansion of the company's single-use manufacturing footprint with plans to increase its presence by 30%. [15]
The company ranked 485th in 2023 and 506 in 2024 on the Fortune 500, based on its sales records. [16] [3]
On August 26, 2020, Bloomberg News implicated Avantor and other companies in the U.S. opioid epidemic. [17] According to Bloomberg, one of their compounds "acetic anhydride", was used illicitly by drug traffickers to convert crude opium into heroin. Bloomberg also found evidence that Avantor's compound was used in cartel drug labs, and that regulations implemented in 2018 didn't stop it from being widely available. [18] In response, Avantor discontinued all sales of acetic anhydride in Mexico and destroyed its existing inventory. In 2021, Texas Senator John Cornyn, who serves on both the Judiciary Committee and the bipartisan Caucus on International Narcotics Control claims that Avantor should have known better, selling acetic anhydride within Mexico's unregulated market. What should have raised eyebrows as well is that it was sold in 18-liter containers, which is inconsistent with the ordinary use of acetic anhydride. [19] Four other Republican senators also deplored Avantor's “apparent longstanding contribution to the opioid epidemic that killed 50,000 of our fellow citizens in 2019.” [20]
Celanese Corporation, formerly known as Hoechst Celanese, is an American technology and specialty materials company headquartered in Irving, Texas. It is a Fortune 500 corporation. The company is the world's leading producer of acetic acid, producing about 1.95 million tonnes per year, representing approximately 25% of global production. Celanese is also the world's largest producer of vinyl acetate monomer (VAM).
In biochemistry, cellulose acetate refers to any acetate ester of cellulose, usually cellulose diacetate. It was first prepared in 1865. A bioplastic, cellulose acetate is used as a film base in photography, as a component in some coatings, and as a frame material for eyeglasses; it is also used as a synthetic fiber in the manufacture of cigarette filters and playing cards. In photographic film, cellulose acetate film replaced nitrate film in the 1950s, being far less flammable and cheaper to produce.
Fischer esterification or Fischer–Speier esterification is a special type of esterification by refluxing a carboxylic acid and an alcohol in the presence of an acid catalyst. The reaction was first described by Emil Fischer and Arthur Speier in 1895. Most carboxylic acids are suitable for the reaction, but the alcohol should generally be primary or secondary. Tertiary alcohols are prone to elimination. Contrary to common misconception found in organic chemistry textbooks, phenols can also be esterified to give good to near quantitative yield of products. Commonly used catalysts for a Fischer esterification include sulfuric acid, p-toluenesulfonic acid, and Lewis acids such as scandium(III) triflate. For more valuable or sensitive substrates other, milder procedures such as Steglich esterification are used. The reaction is often carried out without a solvent or in a non-polar solvent that can facilitate Dean–Stark distillation to remove the water byproduct. Typical reaction times vary from 1–10 hours at temperatures of 60–110 °C.
Becton, Dickinson and Company is an American multinational medical technology company that manufactures and sells medical devices, instrument systems, and reagents. BD also provides consulting and analytics services in certain areas.
Clandestine chemistry is chemistry carried out in secret, and particularly in illegal drug laboratories. Larger labs are usually run by gangs or organized crime intending to produce for distribution on the black market. Smaller labs can be run by individual chemists working clandestinely in order to synthesize smaller amounts of controlled substances or simply out of a hobbyist interest in chemistry, often because of the difficulty in ascertaining the purity of other, illegally synthesized drugs obtained on the black market. The term clandestine lab is generally used in any situation involving the production of illicit compounds, regardless of whether the facilities being used qualify as a true laboratory.
Eastman Chemical Company is an American company primarily involved in the chemical industry. Once a subsidiary of Kodak, today it is an independent global specialty materials company that produces a broad range of advanced materials, chemicals and fibers for everyday purposes. Founded in 1920 and based in Kingsport, Tennessee, the company operates 36 manufacturing sites worldwide and employs approximately 14,000 people.
Huntsman Corporation is an American multinational manufacturer and marketer of chemical products for consumers and industrial customers. Huntsman manufactures assorted polyurethanes, performance products, and adhesives for customers like BMW, GE, Chevron, Procter & Gamble, Unilever and Walkaroo. With global headquarters in The Woodlands, Texas, it operates more than 60 manufacturing, R&D and operations facilities in over 25 countries and employ approximately 7,000 associates across three business divisions. Huntsman Corporation had 2023 revenues of approximately $6 billion.
Acetic anhydride, or ethanoic anhydride, is the chemical compound with the formula (CH3CO)2O. Commonly abbreviated Ac2O, it is the simplest isolable anhydride of a carboxylic acid and is widely used as a reagent in organic synthesis. It is a colorless liquid that smells strongly of acetic acid, which is formed by its reaction with moisture in the air.
An organic acid anhydride is an acid anhydride that is also an organic compound. An acid anhydride is a compound that has two acyl groups bonded to the same oxygen atom. A common type of organic acid anhydride is a carboxylic anhydride, where the parent acid is a carboxylic acid, the formula of the anhydride being (RC(O))2O. Symmetrical acid anhydrides of this type are named by replacing the word acid in the name of the parent carboxylic acid by the word anhydride. Thus, (CH3CO)2O is called acetic anhydride.Mixed (or unsymmetrical) acid anhydrides, such as acetic formic anhydride (see below), are known, whereby reaction occurs between two different carboxylic acids. Nomenclature of unsymmetrical acid anhydrides list the names of both of the reacted carboxylic acids before the word "anhydride" (for example, the dehydration reaction between benzoic acid and propanoic acid would yield "benzoic propanoic anhydride").
Sigma-Aldrich is an American chemical, life science, and biotechnology company owned by the multinational chemical conglomerate Merck Group
VWR International is an American company involved in the distribution of research laboratory products, with over 1,200,000 items to more than 250,000 customers in North America and Europe. The U.S. division is headquartered in Radnor, Pennsylvania. VWR ranked #91 in 2006, and #77 in 2005, in Forbes list of largest American private companies. Suppliers include Applied Scientific, 3B Scientific Duracell, Kimberly-Clark, Bel-Art Products, and Welch Allyn. VWR primarily serves the government, biotechnology, life science, education, electronics and pharmaceutical sectors. In 2010, the company maintained operations in 25 countries and processed approximately 50,000 order lines daily from a logistical network, which includes 25 strategically located distribution centers.
Dipropanoylmorphine is an opiate derivative, the 3,6-dipropanoyl ester of morphine. It was developed in 1972 as an analgesic. It is rarely used in some countries for the relief of severe pain such as that caused by terminal cancer, as an alternative to diamorphine (heroin) and morphine. The drug was first synthesised circa or about 1875 in Great Britain along with many other esters of morphine, all of which were shelved at the time, some of which were later developed such as heroin (1898), acetylpropionylmorphine (1924), dibenzoylmorphine, and so on. The name of this drug is also given as 3,6-dipropanoylmorphine and its 6-mono-acetylated homologue is also a longer-acting heroin-like drug, as are 3,6-diformylmorphine and 6-formylmorphine.
Thermo Fisher Scientific Inc. is an American-headquartered life science and clinical research company. It is a global supplier of analytical instruments, clinical development solutions, specialty diagnostics, laboratory, pharmaceutical and biotechnology services. Based in Waltham, Massachusetts, Thermo Fisher was formed through the merger of Thermo Electron and Fisher Scientific in 2006. Thermo Fisher Scientific has acquired other reagent, consumable, instrumentation, and service providers, including Life Technologies Corporation (2013), Alfa Aesar (2015), Affymetrix (2016), FEI Company (2016), BD Advanced Bioprocessing (2018), and PPD (2021).
Mallinckrodt Pharmaceuticals plc is an American-Irish domiciled manufacturer of specialty pharmaceuticals, generic drugs and imaging agents. In 2017, it generated 90% of its sales from the U.S. healthcare system. While Mallinckrodt is headquartered in Ireland for tax purposes, its operational headquarters are in the U.S. Mallinckrodt's 2013 tax inversion to Ireland drew controversy when it was shown Acthar was Medicaid's most expensive drug.
Puritan Bennett has been a provider of respiratory products since 1913 originally as a medical gas supplier. In addition to critical care ventilation, Puritan Bennett provided medical devices for patients outside of the acute care environment. Its products included portable ventilation, oxygen therapy systems, sleep diagnostic and sleep therapy equipment, spirometry and other respiratory care products.
The illegal drug trade in China is influenced by factors such as history, location, size, population, and current economic conditions. China has one-sixth of the world's population and a large and expanding economy. China's large land mass, close proximity to the Golden Triangle, Golden Crescent, and numerous coastal cities with large and modern port facilities make it an attractive transit center for drug traffickers. Opium has played an important role in the country's history since before the First and Second Opium Wars in the mid-19th century.
Acetic acid, systematically named ethanoic acid, is an acidic, colourless liquid and organic compound with the chemical formula CH3COOH. Vinegar is at least 4% acetic acid by volume, making acetic acid the main component of vinegar apart from water. It has been used, as a component of vinegar, throughout history from at least the third century BC.
Drug precursors, also referred to as precursor chemicals or simply precursors, are substances used to manufacture illicit drugs. Most precursors also have legitimate commercial uses and are legally used in a wide variety of industrial processes and consumer products, such as medicines, flavourings, and fragrances.
The chemical industry of India is a major industry in the Indian economy and as of 2022, contributes 7% of the country's Gross Domestic Product (GDP). India is the world's sixth largest producer of chemicals and the third largest in Asia, as of 2022. The value of the Indian chemical industry was estimated at $100 billion dollars in 2019. The chemical industry of India generates employment for five million people. The Indian chemical industry produces 80,000 different chemical products. India was also the third largest producer of plastic in 2019. As of September 2019, the alkali chemical industry produced 71% of all chemicals produced in India. India's chemical industry accounts about 14% of production in Indian industries.
Acetylated wood is a type of modified wood that is produced through a chemical modification process and does not contain any toxic substances. It produced from a chemical reaction, involving acetic anhydride and a modification process to make wood highly resistant to biological attacks by fungi and wood-boring insects and durable to environmental conditions. It is a new wood product in the field of wood science, following decades of research and experimentation.
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