Related Research Articles
Gamma-glutamyltransferase is a transferase that catalyzes the transfer of gamma-glutamyl functional groups from molecules such as glutathione to an acceptor that may be an amino acid, a peptide or water. GGT plays a key role in the gamma-glutamyl cycle, a pathway for the synthesis and degradation of glutathione as well as drug and xenobiotic detoxification. Other lines of evidence indicate that GGT can also exert a pro-oxidant role, with regulatory effects at various levels in cellular signal transduction and cellular pathophysiology. This transferase is found in many tissues, the most notable one being the liver, and has significance in medicine as a diagnostic marker.
Angiotensin-converting enzyme, or ACE, is a central component of the renin–angiotensin system (RAS), which controls blood pressure by regulating the volume of fluids in the body. It converts the hormone angiotensin I to the active vasoconstrictor angiotensin II. Therefore, ACE indirectly increases blood pressure by causing blood vessels to constrict. ACE inhibitors are widely used as pharmaceutical drugs for treatment of cardiovascular diseases.
Cytosol alanyl aminopeptidase is an enzyme.
Carboxypeptidase B is a carboxypeptidase that preferentially acts upon basic amino acids, such as arginine and lysine. This serum enzyme is also responsible for rapidly metabolizing the C5a protein into C5a des-Arg, with one less amino acid.
Fumarylacetoacetase is an enzyme that in humans is encoded by the FAH gene located on chromosome 15. The FAH gene is thought to be involved in the catabolism of the amino acid phenylalanine in humans.
Extracellular superoxide dismutase [Cu-Zn] is an enzyme that in humans is encoded by the SOD3 gene.
6-phosphofructokinase, muscle type is an enzyme that in humans is encoded by the PFKM gene on chromosome 12. Three phosphofructokinase isozymes exist in humans: muscle, liver and platelet. These isozymes function as subunits of the mammalian tetramer phosphofructokinase, which catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-bisphosphate. Tetramer composition varies depending on tissue type. This gene encodes the muscle-type isozyme. Mutations in this gene have been associated with glycogen storage disease type VII, also known as Tarui disease. Alternatively spliced transcript variants have been described.[provided by RefSeq, Nov 2009]
6-phosphofructokinase, liver type (PFKL) is an enzyme that in humans is encoded by the PFKL gene on chromosome 21. This gene encodes the liver (L) subunit of an enzyme that catalyzes the conversion of D-fructose 6-phosphate to D-fructose 1,6-bisphosphate, which is a key step in glucose metabolism (glycolysis). This enzyme is a tetramer that may be composed of different subunits encoded by distinct genes in different tissues. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2014]
Alpha-amylase 2B is an enzyme that in humans is encoded by the AMY2B gene.
Dipeptidase 1 (DPEP1), or renal dipeptidase, is a membrane-bound glycoprotein responsible for hydrolyzing dipeptides. It is found in the microsomal fraction of the porcine kidney cortex. It exists as a disulfide-linked homodimer that is glygosylphosphatidylinositol (GPI)-anchored to the renal brush border of the kidney. The active site on each homodimer is made up of a barrel subunit with binuclear zinc ions that are bridged by the Gly125 side-chain located at the bottom of the barrel.
Beta-Ala-His dipeptidase is an enzyme that in humans is encoded by the CNDP1 gene.
Xylosyltransferase 2 is an enzyme that in humans is encoded by the XYLT2 gene.
Carnosinemia is a rare autosomal recessive metabolic disorder caused by a deficiency of carnosinase, a dipeptidase.
Hypertryptophanemia is a rare autosomal recessive metabolic disorder that results in a massive buildup of the amino acid tryptophan in the blood, with associated symptoms and tryptophanuria.
Xaa-His dipeptidase is an enzyme. This enzyme catalyses the following chemical reaction
Xaa-methyl-His dipeptidase is an enzyme. This enzyme catalyses the following chemical reaction
Cytosolic non-specific dipeptidase also known as carnosine dipeptidase 2 is an enzyme that in humans is encoded by the CNDP2 gene. This enzyme catalyses the hydrolysis of dipeptides, preferentially those containing hydrophobic amino acids. The human enzyme uses manganese ions as a cofactor. In addition to its function as a peptidase, the enzyme also functions to generate N-lactoyl amino acids, such as N-lactoyl-phenylalanine, via the process of "reverse proteolysis".
Alkaline phosphatase, placental-like 2 is a protein that in humans is encoded by the ALPPL2 gene.
Morus indica is a member of the genus Morus, of the family of flowering plants Moraceae, commonly known as the mulberry family. As with other mulberries, Morus indica is a deciduous tree. Morus indica is native to the temperate and sub-tropical Himalayan region. It is currently cultivated in India, China, Japan, and East Africa.
Paul Jacob Brombacher was a Dutch clinical chemist, professor at Maastricht University and the head clinical chemist at De Wever Hospital in Heerlen.
References
- ↑ Lenney JF, George RP, Weiss AM, Kucera CM, Chan PW, Rinzler GS (August 1982). "Human serum carnosinase: characterization, distinction from cellular carnosinase, and activation by cadmium". Clinica Chimica Acta; International Journal of Clinical Chemistry. 123 (3): 221–31. doi:10.1016/0009-8981(82)90166-8. PMID 7116644.
- ↑ Jackson MC, Kucera CM, Lenney JF (February 1991). "Purification and properties of human serum carnosinase". Clinica Chimica Acta; International Journal of Clinical Chemistry. 196 (2–3): 193–205. doi:10.1016/0009-8981(91)90073-L. PMID 1903095.
