Biliary endoscopic sphincterotomy

Last updated
Biliary endoscopic sphincterotomy
Pigment stone extraction.png
Duodenoscopic image of two pigment stones extracted from common bile duct after sphincterotomy
ICD-9-CM 51.85

Biliary endoscopic sphincterotomy is a procedure where the sphincter of Oddi and the segment of the common bile duct where it enters the duodenum are cannulated and then cut with a sphincterotome, a device that includes a wire which cuts with an electric current (electrocautery). [1]

Contents

This procedure was developed in both Germany and Japan and was first published in each nation in 1974. [2] [3] It has become a very common technique, useful for treatment of a wide variety of conditions of the biliary system such as the evacuation of gallstones within the bile duct (choledocholithiasis), biliary or papillary strictures, sphincter of Oddi dysfunction, bile leaks, and others. In addition, it is commonly performed during an endoscopic retrograde cholangiopancreatography (ERCP), and it may be used for facilitating diagnostic procedures such as transpapillary bile duct biopsy, papillary tumor biopsy, and insertion of a cholangioscope. [1]

Medical Uses

Therapeutic

Extraction of choledocholithiasis and/or intrahepatic stones: choledocholithiasis is the presence of gallstones within the common bile duct. They can be either primary (formed within the duct) or secondary (entering the duct from the gallbladder). Biliary endoscopic sphincterotomy allows for opening of the sphincter of Oddi, allowing stones to be removed. [4]

Treatment of benign biliary/papillary strictures: diseases such as primary sclerosing cholangitis can lead to fibrosis and stricture of the ducts of the biliary tree. These strictures can cause cholestasis which can lead to jaundice, pruritus, cholangitis, and gallstone formation. Biliary endoscopic sphincterotomy is sometimes used, with or without stenting, to relieve the obstruction, but systematic reviews have not demonstrated consistent benefits. [5]

Treatment of sphincter of Oddi dysfunction: this is a diagnosis of exclusion which encompasses a broad spectrum of hepatobiliary disorders including spasms, strictures, or inappropriate relaxation. Sphincterotomy appears to be safe and effective for the treatment of sphincter of Oddi dysfunction. [6]

Treatment of bile leaks: leakage of bile into the abdominal cavity is a complication of laparoscopic cholecystectomy. The purpose of biliary endoscopic sphincterotomy in the treatment of a bile leak is to reduce or eliminate the pressure gradient between the bile duct and the duodenum, encouraging transpapillary bile flow and allowing the leak to heal. [7]

Others:

Diagnostic

Contraindications

Bleeding/coagulopathy: platelet count and international normalized ratio (INR) should be checked before the procedure. Discontinuation of antiplatelet therapy or anticoagulation requires consideration of the risks of hemorrhage vs. thrombosis and management should be based on current guidelines. [8] [9]

Procedure

Equipment

Sphincterotomes: a sphincterotome (also called a papillotome) is a catheter with a cutting wire at its far end. They have various configurations based on cutting wire length, outer diameter, number of lumens, and presence of other features such as the ability to rotate. The sphincterotome is connected to an electrosurgical generator, allowing the cutting wire to function as a knife when an electrical current is applied. Additional lumens allow the addition of a guidewire and injection of radio-opaque contrast. They can be broadly categorized as pull-type, push-type, or needle-knife. [1]

Pull-type: pull-type sphincterotomes consist of a steel cutting wire within a Teflon catheter. The wire exits the catheter approximately 3 cm before its distal end and re-enters the catheter approximately 3 mm from its tip. When tension is applied to the wire, the distal portion of the catheter becomes curved so that the exposed wire is brought upwards into contact with the biliary sphincter and papilla, away from the catheter. [1]

Push-type: push-type sphincterotomes have a similar design to pull-type, but instead tightening the wire pushes it out to form a bow oriented downwards. This is useful for patients with Billroth II anatomy. [1]

Needle-knife: a needle-knife sphincterotome has a retractable cutting wire of 3 to 5 mm with a Teflon sheath. They are most often used for a pre-cut sphincterotomy when standard methods of cannulation fail. [1]

Technique

Standard sphincterotomy: the sphincterotome is inserted into the bile duct. A cholangiogram is then used to evaluate any biliary abnormalities requiring further intervention. The papilla is then incised with the cutting wire by applying electrocautery. [1]

Pre-cut sphincterotomy: pre-cut biliary endoscopic sphincterotomy refers to the techniques used to cut the papillary mucosa and biliary sphincter in order to expose the underlying bile duct and gain access to it when standard cannulation fails. [1]

Transpancreatic biliary sphincterotomy (septotomy): when the guidewire is unintentionally inserted into the main pancreatic duct the sphincterotome is then placed in the pancreatic duct and used to cut the septum between the pancreatic duct and bile duct. It is then withdrawn and re-directed through the incision site into the bile duct with the guidewire. [1]

Needle knife papillotomy: a needle knife sphincterotome is placed en face to the biliary papilla. An incision is then made stepwise, starting at the upper margin of the papillary orifice and extending towards the biliary sphincter, creating an incision to allow the bile duct to be cannulated. [1]

Needle knife fistulotomy: a needle knife fistulotomy has two different technique which are used. For the first technique an incision is made a few millimeters above the opening to the duct and then extended upwards. The other option is to make an incision in the roof of the papilla and then extend it either up or down without cutting the papillary orifice itself. [1] The rate of pancreatitis after ERCP was significantly lower after fistulotomy, compared to other precut techniques. [1]

Modifications for anatomic variations

Periampullary diverticulum: periampullary diverticulum makes the procedure more difficult because it becomes harder to assess the incision. [10] Needle-knife fistulotomy or pancreatic stent placement followed by precut sphincterotomy are two of several techniques that have been used to account for the increased difficulty. [11]

Surgically altered anatomy (Billroth II): if a patient has undergone a partial gastrectomy with Billroth II anastomosis, the papilla may appear to be upside down from the perspective of the endoscope compared to normal. Cannulation may need to be performed in a reverse position with the bile duct oriented downwards. [1]

Risks

The reported overall incidence of complications associated with ERCP and biliary endoscopic sphincterotomy has ranged from 3 to 12 percent. [12]

Pancreatitis:  biliary endoscopic sphincterotomy is not an independent risk factor for pancreatitis after ERCP. [1]

Bleeding: immediate bleeding occurs during or immediately after biliary endoscopic sphincterotomy. It is seen in up to 30% of patients and self-limiting most of the time. Delayed bleeding occurs from a few hours up to 2 wk after the procedure. [13]

Perforation: the incidence of sphincterotomy related perforation, also named Type 2 duodenal perforation, is between 0% and 1.8%. [12]

Cholangitis/sepsis: the incidence of cholangitis after biliary endoscopic sphincterotomy is between 1% and 3%. [1]

Late complications: long-term complication vs of biliary endoscopic sphincterotomy include recurrent common bile duct stone, cholecystitis, cholangitis, hepatic abscess, papillary stenosis and biliary stricture. [12]

Alternatives

Balloon Dilation: balloon dilation is an alternative often used in patients with a coagulation disorder or if their anatomy makes a traditional sphincterotomy more difficult. Balloon dilation is associated with fewer long term complications owing to preservations of sphincter function. [14]

See also

Related Research Articles

<span class="mw-page-title-main">Cholecystectomy</span> Surgical removal of the gallbladder

Cholecystectomy is the surgical removal of the gallbladder. Cholecystectomy is a common treatment of symptomatic gallstones and other gallbladder conditions. In 2011, cholecystectomy was the eighth most common operating room procedure performed in hospitals in the United States. Cholecystectomy can be performed either laparoscopically, or via an open surgical technique.

<span class="mw-page-title-main">Endoscopic retrograde cholangiopancreatography</span> Use of endoscopy and fluoroscopy to treat and diagnose digestive issues.

Endoscopic retrograde cholangiopancreatography (ERCP) is a technique that combines the use of endoscopy and fluoroscopy to diagnose and treat certain problems of the biliary or pancreatic ductal systems. It is primarily performed by highly skilled and specialty trained gastroenterologists. Through the endoscope, the physician can see the inside of the stomach and duodenum, and inject a contrast medium into the ducts in the biliary tree and pancreas so they can be seen on radiographs.

<span class="mw-page-title-main">Primary sclerosing cholangitis</span> Medical condition

Primary sclerosing cholangitis (PSC) is a long-term progressive disease of the liver and gallbladder characterized by inflammation and scarring of the bile ducts, which normally allow bile to drain from the gallbladder. Affected individuals may have no symptoms or may experience signs and symptoms of liver disease, such as yellow discoloration of the skin and eyes, itching, and abdominal pain.

<span class="mw-page-title-main">Common bile duct stone</span> Medical condition

Common bile duct stone, also known as choledocholithiasis, is the presence of gallstones in the common bile duct (CBD). This condition can cause jaundice and liver cell damage. Treatments include choledocholithotomy and endoscopic retrograde cholangiopancreatography (ERCP).

<span class="mw-page-title-main">Ampulla of Vater</span> Organ duct

The ampulla of Vater, hepatopancreatic ampulla or hepatopancreatic duct is the common duct that is usually formed by a union of the common bile duct and the pancreatic duct within the wall of the duodenum. This common duct usually features a dilation ("ampulla"). The common duct then opens medially into the descending part of the duodenum at the major duodenal papilla. The common duct usually measures 2-10mm in length.

<span class="mw-page-title-main">Magnetic resonance cholangiopancreatography</span> Medical imaging technique

Magnetic resonance cholangiopancreatography (MRCP) is a medical imaging technique. It uses magnetic resonance imaging to visualize the biliary and pancreatic ducts non-invasively. This procedure can be used to determine whether gallstones are lodged in any of the ducts surrounding the gallbladder.

<span class="mw-page-title-main">Pancreas divisum</span> Congenital disorder of digestive system

Pancreatic divisum is a congenital anomaly in the anatomy of the ducts of the pancreas in which a single pancreatic duct is not formed, but rather remains as two distinct dorsal and ventral ducts. Most individuals with pancreas divisum remain without symptoms or complications. A minority of people with pancreatic divisum may develop episodes of abdominal pain, nausea or vomiting due to acute or chronic pancreatitis. The presence of pancreas divisum is usually identified with cross sectional diagnostic imaging, such as endoscopic retrograde cholangiopancreatography (ERCP) or magnetic resonance cholangiopancreatography (MRCP). In some cases, it may be detected intraoperatively. If no symptoms or complications are present, then treatment is not necessary. However, if there is recurrent pancreatitis, then a sphincterotomy of the minor papilla may be indicated.

<span class="mw-page-title-main">Endoscopic ultrasound</span> Medical imaging procedure

Endoscopic ultrasound (EUS) or echo-endoscopy is a medical procedure in which endoscopy is combined with ultrasound to obtain images of the internal organs in the chest, abdomen and colon. It can be used to visualize the walls of these organs, or to look at adjacent structures. Combined with Doppler imaging, nearby blood vessels can also be evaluated.

<span class="mw-page-title-main">Ascending cholangitis</span> Medical condition

Ascending cholangitis, also known as acute cholangitis or simply cholangitis, is inflammation of the bile duct, usually caused by bacteria ascending from its junction with the duodenum. It tends to occur if the bile duct is already partially obstructed by gallstones.

<span class="mw-page-title-main">Major duodenal papilla</span>

The major duodenal papilla is a rounded projection in the duodenum into which the common bile duct and pancreatic duct drain. The major duodenal papilla is, in most people, the primary mechanism for the secretion of bile and other enzymes that facilitate digestion.

<span class="mw-page-title-main">Self-expandable metallic stent</span>

A self-expandable metallic stent is a metallic tube, or stent that holds open a structure in the gastrointestinal tract to allow the passage of food, chyme, stool, or other secretions related to digestion. Surgeons insert SEMS by endoscopy, inserting a fibre optic camera—either through the mouth or colon—to reach an area of narrowing. As such, it is termed an endoprosthesis. SEMS can also be inserted using fluoroscopy where the surgeon uses an X-ray image to guide insertion, or as an adjunct to endoscopy.

<span class="mw-page-title-main">Percutaneous transhepatic cholangiography</span> Medical imaging of the biliary tract

Percutaneous transhepatic cholangiography, percutaneous hepatic cholangiogram (PTHC) is a radiological technique used to visualize the anatomy of the biliary tract. A contrast medium is injected into a bile duct in the liver, after which X-rays are taken. It allows access to the biliary tree in cases where endoscopic retrograde cholangiopancreatography has been unsuccessful. Initially reported in 1937, the procedure became popular in 1952.

Papillary stenosis is a disturbance of the sphincter of Oddi, a muscular valve, that prevents the opening and release of bile or pancreatic fluids into the duodenum in response to food entering the duodenum.

<span class="mw-page-title-main">Pneumobilia</span> Medical condition

Pneumobilia is the presence of gas in the biliary system. It is typically detected by ultrasound or a radiographic imaging exam, such as CT, or MRI. It is a common finding in patients that have recently undergone biliary surgery or endoscopic biliary procedure. While the presence of air within biliary system is not harmful, this finding may alternatively suggest a pathological process, such as a biliary-enteric anastomosis, an infection of the biliary system, an incompetent sphincter of Oddi, or spontaneous biliary-enteric fistula.

<span class="mw-page-title-main">Sphincter of Oddi dysfunction</span> Medical condition

Sphincter of Oddi dysfunction refers to a group of functional disorders leading to abdominal pain due to dysfunction of the Sphincter of Oddi: functional biliary sphincter of Oddi and functional pancreatic sphincter of Oddi disorder. The sphincter of Oddi is a sphincter muscle, a circular band of muscle at the bottom of the biliary tree which controls the flow of pancreatic juices and bile into the second part of the duodenum. The pathogenesis of this condition is recognized to encompass stenosis or dyskinesia of the sphincter of Oddi ; consequently the terms biliary dyskinesia, papillary stenosis, and postcholecystectomy syndrome have all been used to describe this condition. Both stenosis and dyskinesia can obstruct flow through the sphincter of Oddi and can therefore cause retention of bile in the biliary tree and pancreatic juice in the pancreatic duct.

Peter B. Cotton is a British Gastroenterologist best known for his advancement in digestive disease, pioneering and naming the ERCP procedure and creating the Digestive Disease Center at the Medical University of South Carolina.

Sphincter of Oddi Muscular valve that controls the rate of flow of bile and pancreatic juice into the duodenum

The sphincter of Oddi, abbreviated as SO, is a muscular valve that in some animals, including humans, controls the flow of bile and pancreatic juice out of the gallbladder and pancreas respectively through the ampulla of Vater into the second part of the duodenum. It is named after Ruggero Oddi.

<span class="mw-page-title-main">Michel Kahaleh</span>

Michel Kahaleh is an American gastroenterologist and an expert in therapeutic endoscopy.

<span class="mw-page-title-main">Choledochoduodenostomy</span>

Choledochoduodenostomy (CDD) is a surgical procedure to create an anastomosis, a surgical connection, between the common bile duct (CBD) and an alternative portion of the duodenum. In healthy individuals, the CBD meets the pancreatic duct at the ampulla of Vater, which drains via the major duodenal papilla to the second part of duodenum. In cases of benign conditions such as narrowing of the distal CBD or recurrent CBD stones, performing a CDD provides the diseased patient with CBD drainage and decompression. A side-to-side anastomosis is usually performed.

<span class="mw-page-title-main">Nib Soehendra</span> German surgeon (born 1942)

Nib Soehendra is a German surgeon known for numerous contributions to the field of endoscopy and therapeutic endoscopy.

References

  1. 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 Köksal, Aydın Şeref; Eminler, Ahmet Tarik; Parlak, Erkan (2018-12-26). "Biliary endoscopic sphincterotomy: Techniques and complications". World Journal of Clinical Cases. 6 (16): 1073–1086. doi: 10.12998/wjcc.v6.i16.1073 . ISSN   2307-8960. PMC   6306628 . PMID   30613665.
  2. Classen, M.; Demling, L. (March 1974). "Endoskopische Sphinkterotomie der Papilla Vateri und Steinextraktion aus dem Ductus choledochus". Deutsche Medizinische Wochenschrift (in German). 99 (11): 496–497. doi:10.1055/s-0028-1107790. ISSN   0012-0472. PMID   4835515. S2CID   72295600.
  3. Kawai, K.; Akasaka, Y.; Murakami, K.; Tada, M.; Kohli, Y.; Nakajima, M. (May 1974). "Endoscopic sphincterotomy of the ampulla of Vater". Gastrointestinal Endoscopy. 20 (4): 148–151. doi:10.1016/S0016-5107(74)73914-1. PMID   4825160.
  4. Ishii, Shigeto; Isayama, Hiroyuki; Ushio, Mako; Takahashi, Sho; Yamagata, Wataru; Takasaki, Yusuke; Suzuki, Akinori; Ochiai, Kazushige; Tomishima, Ko; Kanazawa, Ryo; Saito, Hiroaki (2020-11-25). "Best Procedure for the Management of Common Bile Duct Stones via the Papilla: Literature Review and Analysis of Procedural Efficacy and Safety". Journal of Clinical Medicine. 9 (12): 3808. doi: 10.3390/jcm9123808 . ISSN   2077-0383. PMC   7760048 . PMID   33255554.
  5. Karlsen, Tom H.; Folseraas, Trine; Thorburn, Douglas; Vesterhus, Mette (December 2017). "Primary sclerosing cholangitis – a comprehensive review". Journal of Hepatology. 67 (6): 1298–1323. doi: 10.1016/j.jhep.2017.07.022 . PMID   28802875.
  6. Afghani, Elham; Lo, Simon K.; Covington, Paul S.; Cash, Brooks D.; Pandol, Stephen J. (2017-01-30). "Sphincter of Oddi Function and Risk Factors for Dysfunction". Frontiers in Nutrition. 4: 1. doi: 10.3389/fnut.2017.00001 . ISSN   2296-861X. PMC   5276812 . PMID   28194398.
  7. Rio-Tinto, Ricardo; Canena, Jorge (2021). "Endoscopic Treatment of Post-Cholecystectomy Biliary Leaks". GE - Portuguese Journal of Gastroenterology. 28 (4): 265–273. doi:10.1159/000511527. ISSN   2341-4545. PMC   8314759 . PMID   34386554.
  8. Nelson, Douglas B.; Freeman, Martin L. (December 1994). "Major Hemorrhage from Endoscopic Sphincterotomy: Risk Factor Analysis". Journal of Clinical Gastroenterology. 19 (4): 283–287. doi:10.1097/00004836-199412000-00004. ISSN   0192-0790. PMID   7876506.
  9. Veitch, Andrew M; Vanbiervliet, Geoffroy; Gershlick, Anthony H; Boustiere, Christian; Baglin, Trevor P; Smith, Lesley-Ann; Radaelli, Franco; Knight, Evelyn; Gralnek, Ian M; Hassan, Cesare; Dumonceau, Jean-Marc (March 2016). "Endoscopy in patients on antiplatelet or anticoagulant therapy, including direct oral anticoagulants: British Society of Gastroenterology (BSG) and European Society of Gastrointestinal Endoscopy (ESGE) guidelines". Gut. 65 (3): 374–389. doi:10.1136/gutjnl-2015-311110. ISSN   0017-5749. PMC   4789831 . PMID   26873868.
  10. Boix, Jaume; Lorenzo-Z????iga, Vicente; A??a??os, Fidel; Dom??nech, Eugeni; Morillas, Rosa M.; Gassull, Miguel A. (August 2006). "Impact of Periampullary Duodenal Diverticula at Endoscopic Retrograde Cholangiopancreatography: A Proposed Classification of Periampullary Duodenal Diverticula". Surgical Laparoscopy, Endoscopy & Percutaneous Techniques. 16 (4): 208–211. doi:10.1097/00129689-200608000-00002. ISSN   1530-4515. PMID   16921297. S2CID   34351692.
  11. Park, Chung Su; Park, Chang Hwan; Koh, Han Ra; Jun, Chung Hwan; Ki, Ho Seok; Park, Seon Young; Kim, Hyun Soo; Choi, Sung Kyu; Rew, Jong Sun (September 2012). "Needle-knife fistulotomy in patients with periampullary diverticula and difficult bile duct cannulation: Fistulotomy in periampullary diverticula". Journal of Gastroenterology and Hepatology. 27 (9): 1480–1483. doi:10.1111/j.1440-1746.2012.07201.x. PMID   22694291. S2CID   7289442.
  12. 1 2 3 Ryozawa, Shomei; Itoi, Takao; Katanuma, Akio; Okabe, Yoshinobu; Kato, Hironari; Horaguchi, Jun; Fujita, Naotaka; Yasuda, Kenjiro; Tsuyuguchi, Toshio; Fujimoto, Kazuma (March 2018). "Japan Gastroenterological Endoscopy Society guidelines for endoscopic sphincterotomy". Digestive Endoscopy. 30 (2): 149–173. doi: 10.1111/den.13001 . ISSN   0915-5635. PMID   29247546. S2CID   3819749.
  13. Rustagi, Tarun; Jamidar, Priya A. (January 2015). "Endoscopic Retrograde Cholangiopancreatography–Related Adverse Events". Gastrointestinal Endoscopy Clinics of North America. 25 (1): 97–106. doi:10.1016/j.giec.2014.09.005. PMID   25442961.
  14. Liao, Wei–Chih; Tu, Yu–Kang; Wu, Ming–Shiang; Wang, Hsiu–Po; Lin, Jaw–Town; Leung, Joseph W.; Chien, Kuo–Liong (October 2012). "Balloon Dilation With Adequate Duration Is Safer Than Sphincterotomy for Extracting Bile Duct Stones: A Systematic Review and Meta-analyses". Clinical Gastroenterology and Hepatology. 10 (10): 1101–1109. doi:10.1016/j.cgh.2012.05.017. PMID   22642953.