CD5L

CD5L
Identifiers
Aliases	CD5L , AIM, API6, PRO229, SP-ALPHA, Spalpha, CT-2, hAIM, CD5 molecule like
External IDs	OMIM: 602592 MGI: 1334419 HomoloGene: 55936 GeneCards: CD5L
Gene location (Human)
Chr.	Chromosome 1 (human)
End	157,898,256 bp
Gene location (Mouse)
Chr.	Chromosome 3 (mouse)
End	87,278,380 bp
RNA expression pattern
	Top expressed in
	spleen; ; spongy bone; ; liver; ; right lobe of liver; ; lymph node; ; bone marrow; ; bone marrow cells; ; placenta; ; appendix; ; left ventricle;
	Top expressed in
	left lobe of liver; ; spleen; ; calvaria; ; subcutaneous adipose tissue; ; spermatid; ; seminiferous tubule; ; white adipose tissue; ; sexually immature organism; ; meninges; ; thoracic diaphragm;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	scavenger receptor activity ;
Cellular component	cytoplasm ; extracellular region ; extracellular exosome ; blood microparticle ; membrane ; extracellular space ; plasma membrane ; cell surface ;
Biological process	cellular defense response ; inflammatory response ; receptor-mediated endocytosis ; immune system process ; apoptotic process ; vesicle-mediated transport ; regulation of complement activation ; positive regulation of complement-dependent cytotoxicity ; endocytosis ;
	Sources:Amigo / QuickGO
Orthologs
	922
	11801
	ENSG00000073754
	ENSMUSG00000015854
	O43866
	Q9QWK4
	NM_005894 ; NM_001347698
	NM_009690
	NP_001334627 ; NP_005885
	NP_033820
	Wikidata
View/Edit Human	View/Edit Mouse

Last updated January 30, 2024

CD5 antigen-like is a protein (also known as AIM Apoptosis Inhibitor of Macrophages) that in humans is encoded by the CD5L gene.^[5]^[6]

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References

1 2 3 GRCh38: Ensembl release 89: ENSG00000073754 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000015854 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Gebe JA, Kiener PA, Ring HZ, Li X, Francke U, Aruffo A (Apr 1997). "Molecular cloning, mapping to human chromosome 1 q21-q23, and cell binding characteristics of Spalpha, a new member of the scavenger receptor cysteine-rich (SRCR) family of proteins". J Biol Chem. 272 (10): 6151–8. doi: 10.1074/jbc.272.10.6151 . PMID 9045627.
↑ "Entrez Gene: CD5L CD5 molecule-like".

External links

Human CD5L genome location and CD5L gene details page in the UCSC Genome Browser .

Tissot JD, Schifferli JA, Hochstrasser DF, et al. (1994). "Two-dimensional polyacrylamide gel electrophoresis analysis of cryoglobulins and identification of an IgM-associated peptide". J. Immunol. Methods. 173 (1): 63–75. doi:10.1016/0022-1759(94)90284-4. PMID 8034987.
Tissot JD, Sanchez JC, Vuadens F, et al. (2002). "IgM are associated to Sp alpha (CD5 antigen-like)". Electrophoresis. 23 (7–8): 1203–6. doi:10.1002/1522-2683(200204)23:7/8<1203::AID-ELPS1203>3.0.CO;2-1. PMID 11981870. S2CID 94662015.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC 139241 . PMID 12477932.
Clark HF, Gurney AL, Abaya E, et al. (2003). "The Secreted Protein Discovery Initiative (SPDI), a Large-Scale Effort to Identify Novel Human Secreted and Transmembrane Proteins: A Bioinformatics Assessment". Genome Res. 13 (10): 2265–70. doi:10.1101/gr.1293003. PMC 403697 . PMID 12975309.
Anderson NL, Polanski M, Pieper R, et al. (2004). "The human plasma proteome: a nonredundant list developed by combination of four separate sources". Mol. Cell. Proteomics. 3 (4): 311–26. doi: 10.1074/mcp.M300127-MCP200 . PMID 14718574.
Zhang Z, Henzel WJ (2005). "Signal peptide prediction based on analysis of experimentally verified cleavage sites". Protein Sci. 13 (10): 2819–24. doi:10.1110/ps.04682504. PMC 2286551 . PMID 15340161.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928 . PMID 15489334.
Sarrias MR, Roselló S, Sánchez-Barbero F, et al. (2005). "A role for human Sp alpha as a pattern recognition receptor". J. Biol. Chem. 280 (42): 35391–8. doi: 10.1074/jbc.M505042200 . hdl: 2445/176948 . PMID 16030018.
Gregory SG, Barlow KF, McLay KE, et al. (2006). "The DNA sequence and biological annotation of human chromosome 1". Nature. 441 (7091): 315–21. Bibcode:2006Natur.441..315G. doi: 10.1038/nature04727 . PMID 16710414.

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[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000073754 - Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000015854 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid9045627-5] Gebe JA, Kiener PA, Ring HZ, Li X, Francke U, Aruffo A (Apr 1997). "Molecular cloning, mapping to human chromosome 1 q21-q23, and cell binding characteristics of Spalpha, a new member of the scavenger receptor cysteine-rich (SRCR) family of proteins". J Biol Chem. 272 (10): 6151–8. doi: 10.1074/jbc.272.10.6151 . PMID 9045627.

[entrez-6] "Entrez Gene: CD5L CD5 molecule-like".

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CD5L

Contents

Related Research Articles

References

External links

Further reading