Carboxypeptidase A6

Last updated
CPA6
Identifiers
Aliases CPA6 , CPAH, ETL5, FEB11, carboxypeptidase A6
External IDs OMIM: 609562 MGI: 3045348 HomoloGene: 75130 GeneCards: CPA6
Orthologs
SpeciesHumanMouse
Entrez

57094

329093

Ensembl

ENSG00000165078

ENSMUSG00000042501

UniProt

Q8N4T0

Q5U901

RefSeq (mRNA)

NM_001127445
NM_020361

NM_001289497
NM_177834

RefSeq (protein)

NP_065094

NP_001276426
NP_808502

Location (UCSC) Chr 8: 67.42 – 67.75 Mb Chr 1: 10.39 – 10.79 Mb
PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Carboxypeptidase A6 (CPA6) is a metallocarboxypeptidase enzyme that in humans is encoded by the CPA6 gene. [5] It is highly expressed in the adult mouse olfactory bulb and is broadly expressed in the embryonic brain and other tissues. [6]

Contents

The protein encoded by this gene belongs to the family of carboxypeptidases, which catalyze the release of C-terminal amino acid, and have functions ranging from digestion of food to selective biosynthesis of neuroendocrine peptides. Polymorphic variants and a reciprocal translocation t(6;8)(q26;q13) involving this gene, have been associated with Duane retraction syndrome. [5]

CPA6 processes several neuropeptides, including [Met]- and [Leu]-enkephalin, angiotensin I, and neurotensin in vitro. [6] Whereas CPA6 is capable of converting the enkephalins and neurotensin into inactive forms, it can convert the inactive angiotensin I into the active angiotensin II. [6] CPA6 may have additional roles in processing peptides and proteins in vivo, but the nature of these substrates and the effects of these cleavages are currently unknown.

See also

Related Research Articles

<span class="mw-page-title-main">Met-enkephalin</span> Chemical compound

Met-enkephalin, also known as metenkefalin (INN), sometimes referred to as opioid growth factor (OGF), is a naturally occurring, endogenous opioid peptide that has opioid effects of a relatively short duration. It is one of the two forms of enkephalin, the other being leu-enkephalin. The enkephalins are considered to be the primary endogenous ligands of the δ-opioid receptor, due to their high potency and selectivity for the site over the other endogenous opioids.

<span class="mw-page-title-main">Carboxypeptidase E</span> Protein-coding gene in the species Homo sapiens

Carboxypeptidase E (CPE), also known as carboxypeptidase H (CPH) and enkephalin convertase, is an enzyme that in humans is encoded by the CPE gene. This enzyme catalyzes the release of C-terminal arginine or lysine residues from polypeptides.

<span class="mw-page-title-main">ADAMTS4</span> Protein-coding gene in the species Homo sapiens

A disintegrin and metalloproteinase with thrombospondin motifs 4 is an enzyme that in humans is encoded by the ADAMTS4 gene.

<span class="mw-page-title-main">Neurotensin receptor 2</span> Protein-coding gene in the species Homo sapiens

Neurotensin receptor type 2 is a protein that in humans is encoded by the NTSR2 gene.

<span class="mw-page-title-main">Neurotensin receptor 1</span> Protein-coding gene in the species Homo sapiens

Neurotensin receptor type 1 is a protein that in humans is encoded by the NTSR1 gene. For a crystal structure of NTS1, see pdb code 4GRV. In addition, high-resolution crystal structures have been determined in complex with the peptide full agonist NTS8-13, the non-peptide full agonist SRI-9829, the partial agonist RTI-3a, and the antagonists / inverse agonists SR48692 and SR142948A, as well as in the ligand-free apo state., see PDB codes 6YVR (NTSR1-H4X:NTS8–13), 6Z4V (NTSR1-H4bmX:NTS8–13), 6Z8N (NTSR1-H4X:SRI-9829), 6ZA8 (NTSR1-H4X:RTI-3a), 6Z4S (NTSR1-H4bmX:SR48692), 6ZIN (NTSR1-H4X:SR48692), 6Z4Q, and 6Z66.

<span class="mw-page-title-main">CPM (gene)</span>

Carboxypeptidase M is an enzyme that in humans is encoded by the CPM gene.

<span class="mw-page-title-main">MAP2K5</span>

Dual specificity mitogen-activated protein kinase kinase 5 is an enzyme that in humans is encoded by the MAP2K5 gene.

<span class="mw-page-title-main">ETV1</span> Protein-coding gene in the species Homo sapiens

ETS translocation variant 1 is a protein that in humans is encoded by the ETV1 gene.

<span class="mw-page-title-main">Syntaxin binding protein 3</span> Protein-coding gene in the species Homo sapiens

Syntaxin-binding protein 3 is a protein that in humans is encoded by the STXBP3 gene.

<span class="mw-page-title-main">CPD (gene)</span> Protein-coding gene in the species Homo sapiens

Carboxypeptidase D is an enzyme that in humans is encoded by the CPD gene.

<span class="mw-page-title-main">NLN (gene)</span>

Neurolysin, mitochondrial is a protein that in humans is encoded by the NLN gene. It is a 78-kDa enzyme, widely distributed in mammalian tissues and found in various subcellular locations that vary with cell type. Neurolysin exemplifies the ability of neuropeptidases to target various cleavage site sequences by hydrolyzing them in vitro, and metabolism of neurotensin is the most important role of neurolysin in vivo. Neurolysin has also been implicated in pain control, blood pressure regulation, sepsis, reproduction, cancer biology pathogenesis of stroke, and glucose metabolism.

<span class="mw-page-title-main">Carboxypeptidase A2</span>

Carboxypeptidase A2 is an enzyme that in humans is encoded by the CPA2 gene.

<span class="mw-page-title-main">PRCP</span>

Lysosomal Pro-X carboxypeptidase is an enzyme that in humans is encoded by the PRCP gene.

<span class="mw-page-title-main">CPA3</span>

Carboxypeptidase A3 , also known as CPA3, is an enzyme which in humans is encoded by the CPA3 gene. The "CPA3" gene expression has only been detected in mast cells and mast-cell-like lines, and CPA3 is located in secretory granules. CPA3 is one of 8-9 members of the A/B subfamily that includes the well-studied pancreatic enzymes carboxypeptidase A1 (CPA1), carboxypeptidase A2 (CPA2), and carboxypeptidase B. This subfamily includes 6 carboxypeptidase A-like enzymes, numbered 1-6. The enzyme now called CPA3 was originally named mast cell carboxypeptidase A, and another protein was initially called CPA3. A gene nomenclature committee renamed mast cell carboxypeptidase A as CPA3, and the original CPA3 reported by Huang et al. became CPA4 to reflect the order of their discovery.

<span class="mw-page-title-main">CPZ (gene)</span>

Carboxypeptidase Z is an enzyme that in humans is encoded by the CPZ gene.

<span class="mw-page-title-main">CPA5</span> Protein-coding gene in the species Homo sapiens

Carboxypeptidase A5 is an enzyme that in humans is encoded by the CPA5 gene.

Enkephalinases are enzymes that degrade endogenous enkephalin opioid peptides. They include:

Metallocarboxypeptidase D is an enzyme. This enzyme catalyses the following chemical reaction

Carboxypeptidase D can refer to one of several enzymes. A family of serine carboxypeptidases includes is an enzyme. This enzyme has an optimal pH of 4.5-6.0, is inhibited by diisopropyl fluorophosphate, and catalyses the following chemical reaction

<span class="mw-page-title-main">Ae binding protein 1</span> Protein-coding gene in the species Homo sapiens

AE binding protein 1 is a protein that in humans is encoded by the AEBP1 gene.

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000165078 - Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000042501 - Ensembl, May 2017
  3. ↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. 1 2 "Entrez Gene: Carboxypeptidase A6" . Retrieved 2011-11-25.
  6. 1 2 3 Lyons PJ, Callaway MB, Fricker LD (March 2008). "Characterization of carboxypeptidase A6, an extracellular matrix peptidase". The Journal of Biological Chemistry. 283 (11): 7054–63. doi: 10.1074/jbc.M707680200 . PMID   18178555.

Further reading


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