 | |
| Legal status | |
|---|---|
| Legal status |
|
| Identifiers | |
| |
| CAS Number | |
| PubChem CID | |
| DrugBank | |
| UNII | |
| Chemical and physical data | |
| Formula | C41H50N8O8 |
| Molar mass | 782.899 g·mol−1 |
Coblopasvir is a pharmaceutical drug for the treatment of hepatitis C. [1]
In China, it is approved for use in combination with sofosbuvir for treating naïve or interferon‐experienced adults chronically monoinfected patients with HCV of genotype 1, 2, 3 and 6, with or without compensated cirrhosis. [2]
Hepatitis C is an infectious disease caused by the hepatitis C virus (HCV) that primarily affects the liver; it is a type of viral hepatitis. During the initial infection period, people often have mild or no symptoms. Early symptoms can include fever, dark urine, abdominal pain, and yellow tinged skin. The virus persists in the liver, becoming chronic, in about 70% of those initially infected. Early on, chronic infection typically has no symptoms. Over many years however, it often leads to liver disease and occasionally cirrhosis. In some cases, those with cirrhosis will develop serious complications such as liver failure, liver cancer, or dilated blood vessels in the esophagus and stomach.
The China Theatre Plum Blossom Award, more commonly the Plum Blossom Award, is the highest theatrical award in China. It is awarded by the China Theatre Association.
The Emperor in Han Dynasty, also released under the title The Emperor Han Wu in some countries, is a 2005 Chinese historical drama television series based on the life of Emperor Wu of the Han dynasty. It uses the historical texts Records of the Grand Historian and Book of Han as its source material.
Romance of the Three Kingdoms is a Chinese television series adapted from the classical 14th century novel of the same title by Luo Guanzhong. The series was produced by China Central Television (CCTV) and was first aired on the network in 1994. It spanned a total of 84 episodes, each approximately 45 minutes long. One of the most expensive television series produced at the time, the project cost 170 million yuan. It was completed over four years and involved over 400,000 cast and crew members, including divisions of the People's Liberation Army from the Beijing, Nanjing and Chengdu military regions. Some of the dialogue spoken by characters was adapted directly from the novel. Extensive battle scenes, such as the battles of Guandu, Red Cliffs and Xiaoting, were also live-acted.
Three Kingdoms is a 2010 Chinese television series based on the events in the late Eastern Han dynasty and the Three Kingdoms period. The plot is adapted from the 14th century historical novel Romance of the Three Kingdoms and other stories about the Three Kingdoms period. Directed by Gao Xixi, the series had a budget of over 160 million RMB and took five years of pre-production work. Shooting of the series commenced in October 2008, and it was released in China in May 2010.
Shō-saiko-tō (小柴胡湯), also known as minor bupuleurum formula and xiǎocháihútāng (XCHT), is a herbal supplement, believed to enhance liver health. Sho-Saiko-To is a widely used prescription drug in China and is a listed formula in China and Japan as a Kampo medicine. There are currently ongoing clinical trials for Sho-Saiko-To at University of California, San Diego and Memorial Sloan-Kettering Cancer Center. The active ingredients of sho-saiko-to discovered so far include baicalin, baicalein, glycyrrhizin, saikosaponins, ginsenosides, wogonin, and gingerol.
Royal Tramp is a 2008 Chinese television series adapted from Louis Cha's novel The Deer and the Cauldron. Produced by Zhang Jizhong and Huayi Brothers, the series consists of 50 episodes, filmed in high definition. The series was first broadcast on Jiangsu TV in China in 2008 and was subsequently aired on TVB in Hong Kong and other countries.
The Water Margin is a 1998 Chinese television series adapted from Shi Nai'an's classical 14th-century novel of the same title. It was produced by CCTV with Zhang Jizhong as producer. It was first broadcast in China in January 1998. The series also featured action choreography by Yuen Woo-ping.
All Men Are Brothers is a 2011 Chinese television series adapted from Shi Nai'an's 14th century novel Water Margin, one of the Four Great Classical Novels of Chinese literature. The series is directed by Kuk Kwok-leung and features cast members from mainland China, Taiwan and Hong Kong. The series was first broadcast on 8TV in March 2011 in Malaysia.
Sofosbuvir, sold under the brand name Sovaldi among others, is a medication used to treat hepatitis C. It is taken by mouth.
Justice Bao is a Chinese TV series starring producer Jin Chao-chun as the Song dynasty official Bao Zheng. The series ran for 3 seasons from 2010 to 2012. In addition to Jin, Kenny Ho, Fan Hung-hsuan and Lung Lung again reprise their iconic roles from the 1993 Taiwanese hit Justice Pao and the 2008 Chinese series Justice Bao.
Kwan Shan was a Hong Kong film actor. Kwan appeared as a romantic lead actor in Mandarin-language films created in Hong Kong, especially during the 1960s. His roles included several Shaw Brothers Studio productions.
Simeprevir, sold under the brand name Olysio among others, is a medication used in combination with other medications for the treatment of hepatitis C. It is specifically used for hepatitis C genotype 1 and 4. Medications it is used with include sofosbuvir or ribavirin and peginterferon-alfa. Cure rates are in 80s to 90s percent. It may be used in those who also have HIV/AIDS. It is taken by mouth once daily for typically 12 weeks.
Dasabuvir, sold under the brand name Exviera, is an antiviral medication for the treatment of hepatitis C. It is often used together with the combination medication ombitasvir/paritaprevir/ritonavir specifically for hepatitis C virus (HCV) type 1. Ribavirin may also additionally be used. These combinations result in a cure in more than 90% of people. It is taken by mouth.
Ledipasvir/sofosbuvir, sold under the trade name Harvoni among others, is a medication used to treat hepatitis C. It is a fixed-dose combination of ledipasvir and sofosbuvir. Cure rates are 94% to 99% in people infected with hepatitis C virus (HCV) genotype 1. Some evidence also supports use in HCV genotype 3 and 4. It is taken daily by mouth for 8–24 weeks.
Sofosbuvir/velpatasvir, sold under the brand name Epclusa among others, is a fixed-dose combination medication for the treatment of hepatitis C in adults. It combines sofosbuvir and velpatasvir. It is more than 90% effective for hepatitis C genotypes one through six. It also works for hepatitis C in those who also have cirrhosis or HIV/AIDS. It is taken by mouth.
The Great Emperor in Song Dynasty is a 2015 Chinese historical TV series directed by Gao Xixi, starring Chen Jianbin as Emperor Taizu of Song who founded the Song dynasty and reunified most of China proper.
Word Of Honor, previously titled A Tale of the Wanderers (天涯客), is a 2021 Chinese costume streaming television series co-produced by Ciwen Media, and Youku, directed by Cheng Zhi Chao, Ma Hua Gan, and Li Hong Yu, written by Xiao Chu, adapted from the danmei novel "Faraway Wanderers" (天涯客) by Priest. It starred Zhang Zhehan and Gong Jun in the leading roles. The series aired on Youku from February 22 to May 5 with 36 episodes, plus a short bonus clip shows what happened after the end of the main series.
 | This antiinfective drug article is a stub. You can help Wikipedia by expanding it. |