Leritrelvir

Last updated

Leritrelvir
Leritrelvir.svg
Legal status
Legal status
  • Rx in China
Identifiers
  • (3S,3aS,6aR)-2-[(2S)-2-cyclohexyl-2-[(2,2,2-trifluoroacetyl)amino]acetyl]-N-[(2S)-4-(cyclopentylamino)-3,4-dioxo-1-[(3S)-2-oxopyrrolidin-3-yl]butan-2-yl]-3,3a,4,5,6,6a-hexahydro-1H-cyclopenta[c]pyrrole-3-carboxamide
CAS Number
PubChem CID
ChemSpider
ChEMBL
Chemical and physical data
Formula C31H44F3N5O6
Molar mass 639.717 g·mol−1
3D model (JSmol)
  • C1CCC(CC1)[C@@H](C(=O)N2C[C@@H]3CCC[C@@H]3[C@H]2C(=O)N[C@@H](C[C@@H]4CCNC4=O)C(=O)C(=O)NC5CCCC5)NC(=O)C(F)(F)F
  • InChI=1S/C31H44F3N5O6/c32-31(33,34)30(45)38-23(17-7-2-1-3-8-17)29(44)39-16-19-9-6-12-21(19)24(39)27(42)37-22(15-18-13-14-35-26(18)41)25(40)28(43)36-20-10-4-5-11-20/h17-24H,1-16H2,(H,35,41)(H,36,43)(H,37,42)(H,38,45)/t18-,19-,21-,22-,23-,24-/m0/s1
  • Key:ICGMMLTUQDVAST-HEZDJTGRSA-N

Leritrelvir (RAY1216) is an antiviral drug which acts as a 3C-like protease inhibitor. It was developed and approved [1] in China for treatment of COVID-19. [2] [3] [4] [5] [6]

References

  1. ↑ Zheng L, Wang W, Sun Q (2024). "Targeted drug approvals in 2023: Breakthroughs by the FDA and NMPA". Signal Transduction and Targeted Therapy. 9 (1): 46. doi:10.1038/s41392-024-01770-y. PMC   10879080 . PMID   38378623.
  2. ↑ Chen X, Huang X, Ma Q, Kuzmic P, Zhou B, Zhang S, et al. (April 2024). "Preclinical evaluation of the SARS-CoV-2 Mpro inhibitor RAY1216 shows improved pharmacokinetics compared with nirmatrelvir". Nature Microbiology. 9 (4): 1075–1088. doi:10.1038/s41564-024-01618-9. PMC   10994847 . PMID   38553607.
  3. ↑ Janin YL (January 2024). "On the origins of SARS-CoV-2 main protease inhibitors". RSC Medicinal Chemistry. 15 (1): 81–118. doi:10.1039/d3md00493g. PMC   10809347 . PMID   38283212.
  4. ↑ Chan CC, Guo Q, Chan JF, Tang K, Cai JP, Chik KK, et al. (September 2024). "Identification of novel small-molecule inhibitors of SARS-CoV-2 by chemical genetics". Acta Pharmaceutica Sinica. B. 14 (9): 4028–4044. doi:10.1016/j.apsb.2024.05.026. PMC   11413674 . PMID   39309487.
  5. ↑ Cao Q, Ding Y, Xu Y, Li M, Zheng R, Cao Z, et al. (December 2023). "Small-molecule anti-COVID-19 drugs and a focus on China's homegrown mindeudesivir (VV116)". Frontiers of Medicine. 17 (6): 1068–1079. doi:10.1007/s11684-023-1037-3. PMID   38165534.
  6. ↑ Zheng B, Zhao Q, Yang W, Feng P, Xin C, Ying Y, et al. (March 2024). "Small-molecule antiviral treatments for COVID-19: A systematic review and network meta-analysis". International Journal of Antimicrobial Agents. 63 (3): 107096. doi: 10.1016/j.ijantimicag.2024.107096 . PMID   38244811.{{cite journal}}: CS1 maint: article number as page number (link)


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