Collagen, type VIII, alpha 1

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COL8A1
Protein COL8A1 PDB 1o91.png
Available structures
PDB Ortholog search: PDBe RCSB
Identifiers
Aliases COL8A1 , C3orf7, collagen type VIII alpha 1, collagen type VIII alpha 1 chain
External IDs OMIM: 120251 MGI: 88463 HomoloGene: 22423 GeneCards: COL8A1
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001850
NM_020351

NM_007739

RefSeq (protein)

NP_001841
NP_065084

NP_031765

Location (UCSC) Chr 3: 99.64 – 99.8 Mb Chr 16: 57.44 – 57.58 Mb
PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Collagen alpha-1(VIII) chain is a protein that in humans is encoded by the COL8A1 gene. [5] [6]

This gene encodes one of the two alpha chains of type VIII collagen. The gene product is a short chain collagen and a major component of the basement membrane of the corneal endothelium. The type VIII collagen fibril can be either a homo- or a heterotrimer. Alternatively spliced transcript variants encoding the same isoform have been observed. [6]

Related Research Articles

<span class="mw-page-title-main">Collagen, type XI, alpha 2</span> Protein found in humans

Collagen alpha-2(XI) chain is a protein that in humans is encoded by the COL11A2 gene.

<span class="mw-page-title-main">Collagen, type XVII, alpha 1</span> Mammalian protein found in humans

Collagen XVII, previously called BP180, is a transmembrane protein which plays a critical role in maintaining the linkage between the intracellular and the extracellular structural elements involved in epidermal adhesion, identified by Diaz and colleagues in 1990.

<span class="mw-page-title-main">Collagen, type V, alpha 1</span> Protein found in humans

Collagen alpha-1(V) chain is a protein that in humans is encoded by the COL5A1 gene.

<span class="mw-page-title-main">Collagen, type V, alpha 2</span> Protein found in humans

Collagen alpha-2(V) chain is a protein that in humans is encoded by the COL5A2 gene.

<span class="mw-page-title-main">Collagen, type IV, alpha 5</span> Protein-coding gene in humans

Collagen alpha-5(IV) chain is a protein that in humans is encoded by the COL4A5 gene.

<span class="mw-page-title-main">Collagen, type IV, alpha 3</span> Protein found in humans

Collagen alpha-3(IV) chain is a protein that in humans is encoded by the COL4A3 gene.

<span class="mw-page-title-main">Collagen, type IV, alpha 4</span> Protein found in humans

Collagen alpha-4(IV) chain is a protein that in humans is encoded by the COL4A4 gene.

<span class="mw-page-title-main">Collagen, type IV, alpha 2</span>

Collagen alpha-2(IV) chain is a protein that in humans is encoded by the COL4A2 gene.

<span class="mw-page-title-main">Collagen, type VI, alpha 1</span> Protein found in humans

Collagen alpha-1(VI) chain is a protein that in humans is encoded by the COL6A1 gene.

<span class="mw-page-title-main">Collagen, type X, alpha 1</span> Protein found in humans

Collagen alpha-1(X) chain is a protein that in humans is a member of the collagen family encoded by the COL10A1 gene.

<span class="mw-page-title-main">Laminin subunit alpha-2</span> Protein-coding gene in the species Homo sapiens

Laminin subunit alpha-2 is a protein that in humans is encoded by the LAMA2 gene.

<span class="mw-page-title-main">Collagen, type IV, alpha 6</span> Mammalian protein found in humans

Collagen alpha-6(IV) chain is a protein that in humans is encoded by the COL4A6 gene.

<span class="mw-page-title-main">Collagen, type IX, alpha 1</span> Protein found in humans

Collagen alpha-1(IX) chain is a protein that in humans is encoded by the COL9A1 gene.

<span class="mw-page-title-main">Collagen, type XI, alpha 1</span> Protein found in humans

Collagen alpha-1(XI) chain is a protein that in humans is encoded by the COL11A1 gene.

<span class="mw-page-title-main">Collagen, type IX, alpha 2</span> Protein found in humans

Collagen alpha-2(IX) chain is a protein that in humans is encoded by the COL9A2 gene.

<span class="mw-page-title-main">Collagen, type VIII, alpha 2</span> Protein found in humans

Collagen alpha-2(VIII) chain is a protein that in humans is encoded by the COL8A2 gene. Mutations of the gene are linked to posterior polymorphous dystrophy type 2.

<span class="mw-page-title-main">Collagen, type XIII, alpha 1</span> Protein found in humans

Collagen alpha-1(XIII) chain is a protein that in humans is encoded by the COL13A1 gene.

<span class="mw-page-title-main">Collagen, type XIX, alpha 1</span> Protein found in humans

Collagen alpha-1(XIX) chain is a protein that in humans is encoded by the COL19A1 gene.

<span class="mw-page-title-main">Collagen, type V, alpha 3</span> Protein found in humans

Collagen alpha-3(V) chain is a protein that in humans is encoded by the COL5A3 gene.

<span class="mw-page-title-main">EMID2</span> Mammalian protein found in Homo sapiens

Collagen alpha-1(XXVI) chain is a protein that in humans is encoded by the EMID2 gene.

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000144810 - Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000068196 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Muragaki Y, Mattei MG, Yamaguchi N, Olsen BR, Ninomiya Y (Jun 1991). "The complete primary structure of the human alpha 1 (VIII) chain and assignment of its gene (COL8A1) to chromosome 3". Eur J Biochem. 197 (3): 615–22. doi: 10.1111/j.1432-1033.1991.tb15951.x . PMID   2029894.
  6. 1 2 "Entrez Gene: COL8A1 collagen, type VIII, alpha 1".

Further reading