David Ho

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David Ho
何大一
Ho photo (cropped 3x4).jpg
Ho in 2012
Born (1952-11-03) November 3, 1952 (age 72)
Taichung, Taiwan
Education California Institute of Technology (BS)
Harvard University (MD)
Known for HIV/AIDS research
Awards Ernst Jung Prize (1991)
Bristol-Myers Squibb Award (1996)
American Academy of Arts and Sciences (1997)
Presidential Citizens Medal (2001)
Scientific career
Fields Virology
Institutions Columbia University
Rockefeller University
Chinese name
Chinese 何大一
Transcriptions
Standard Mandarin
Hanyu Pinyin Hé Dà-yī
Gwoyeu Romatzyh Her Dahi
Wade–Giles He2 Ta4-i1
Tongyong Pinyin Hé Dà-yī
Southern Min
Hokkien POJ Hô Tāi-it
Website www.adarc.cuimc.columbia.edu/research/research-labs/ho-lab

David Da-i Ho (Chinese :何大一; pinyin: Hé Dà-yī; born November 3, 1952) is a Taiwanese-American [1] [2] [3] [4] [5] AIDS researcher, physician and virologist who has made a number of scientific contributions to the understanding and treatment of HIV infection. [6] He was a pioneer of combination anti-retroviral therapy instead of single therapy, [7] [8] which turned HIV from an absolute terminal disease into a chronic disease. [9]

Contents

David Ho was born in Taiwan in 1952 and immigrated to the United States in 1965, [10] where he was educated at the California Institute of Technology and Harvard Medical School (through the Harvard–MIT Program in Health Sciences and Technology) before getting his clinical training at UCLA School of Medicine and Massachusetts General Hospital.

He is the founding scientific director of the Aaron Diamond AIDS Research Center [11] and the Clyde and Helen Wu Professor of Medicine at Columbia University Vagelos College of Physicians and Surgeons, [12] both housed at Columbia University Irving Medical Center. [12] [13]

Early life and education

David Ho was born in Taichung, Taiwan, to Paul (何步基; Hé Bùjī), an engineer, and Sonia Ho (née Jiang) (江雙如; Jiāng Shuāngrú). He attended Taichung Municipal Guang-Fu Elementary School until sixth grade before immigrating to the United States with his mother and younger brother to unite with his father, who had already been in the US since 1957. [10]

Ho grew up in Los Angeles and graduated from John Marshall High School. He received his Bachelor of Science in biology with highest honors from the California Institute of Technology (1974). [14] In 1978, Ho earned a Doctor of Medicine (M.D.) from Harvard Medical School.

Career

Ho has been engaged in HIV/AIDS research since the beginning of the pandemic, initially focusing on clinical virology and select topics in HIV pathogenesis, including HIV drug resistance. Before 1996, AZT [8] and other early 1990s antiretroviral medication were prescribed in single therapy, which still did not prevent progression to fatal full-blown AIDS. [8] [15] In the mid-1990s, his research team conducted a series of elegant human studies to elucidate the dynamics of HIV replication in vivo. [16] This knowledge, in turn, formed the foundation for their pioneering effort to treat HIV "early and hard" [8] and in demonstrating for the first time the durable control of HIV replication in patients receiving combination antiretroviral therapy, [17] [18] which had subsequently developed by scientists at NIAID and Merck. [19] He and his ADARC team presented the remarkable results from using combination antiretroviral therapy at International AIDS Conference 1996. [20] This was the turning point in the epidemic that an automatic death sentence was transformed into a manageable disease. [21] [16]

Ho has published more than 500 research papers as of February 2020. [22]

Ho is a member of the Committee of 100, a Chinese American leadership organization, in addition to several scientific groups. [16]

Ho led a team, funded by the Jack Ma Foundation, to look for a vaccine for the COVID-19 virus. [23]

Honors and titles

Ho was Time magazine's 1996 Man of the Year. Time later recalled the selection surprising both Ho and readers. [24] [25] [26] The magazine acknowledged in 1996 that "Ho is not, to be sure, a household name. But some people make headlines while others make history." [24] As of 2024, Ho is the last person to be selected as Person of the Year in a U.S. presidential election year without winning that year's U.S. presidential election. In 1998, he received the Golden Plate Award of the American Academy of Achievement. [27] [28] Ho was even briefly mentioned when Alexander Fleming was considered for Person of the Century in 1999, since Fleming could be portrayed as representative of other disease-fighting scientists including Ho, [29] but the title ultimately went to Albert Einstein.

Ho was the chosen commencement speaker at Caltech, [30] MIT, [31] and Harvard T. H. Chan School of Public Health in 2000.

Ho has received numerous honors and awards for his scientific accomplishments. On January 8, 2001, he was presented with the Presidential Citizens Medal by President Clinton. [32] [33]

On December 6, 2006, California governor Arnold Schwarzenegger and First Lady Maria Shriver inducted Ho into the California Hall of Fame located at The California Museum for History, Women, and the Arts. [34]

Ho was awarded the Distinguished Alumni Award by California Institute of Technology in 2015. [35] Ho received the Portrait of a Nation Prize at the National Portrait Gallery, Smithsonian Institution in 2017. [36]

Other accolades include the Ernst Jung Prize in Medicine, [37] Mayor's Award for Excellence in Science & Technology, the Squibb Award, [38] the Architect of Peace [39] and the Hoechst Marion Roussel Award. [40]

Ho has been elected as a member of the American Academy of Arts and Sciences, Academia Sinica (Taiwan), and the U.S. National Academy of Medicine (formerly Institute of Medicine). [16] He is currently a member of the board of trustees of the California Institute of Technology. [41] He was a member of the Board of Overseers of Harvard University and a board member of the MIT Corporation. [42] [16]

He is also a member of the Chinese Academy of Engineering. [16]

Ho was recognized by the Kingdom of Thailand with the Prince Mahidol Award in Medicine. [43]

Ho was awarded Hamdan Award for Medical Research Excellence - Immunity in 2022. [44]

Personal life

Ho's family's ancestral home is Xinyu, Jiangxi Province. [45] He is married to Tera Wong, with whom he has four children: Kathryn, Jonathan, Jaclyn, and Jerren. [46]

See also

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References

  1. ↑ "9 medical pioneers to celebrate for Asian American and Pacific Islander Heritage Month". Becker's Hospital Review . May 13, 2021. Archived from the original on May 13, 2021. Retrieved October 21, 2023. David Ho, MD, for pioneering treatment of HIV/AIDS. Dr. Ho is a Taiwanese American physician who was named Time's Man of the Year in 1996
  2. ↑ "Asian American, Native Hawaiian and Pacific Islander Pioneers in Medicine & Science". American Neurological Association (ANA). Archived from the original on June 10, 2023. Retrieved October 20, 2023.
  3. ↑ Sen. Russ Feingold (D-WI) noted, "Without the contributions of Taiwanese Americans, we would lack the important AIDS research of Dr. David Ho. Archived September 8, 2008, at the Wayback Machine , Formosan Association for Public Affairs, MAY 2000
  4. ↑ Taiwanese-American HIV/AIDS academic joins team, The Taipei Times, September 4, 2011
  5. ↑ U.S. Public TV Stations to Broadcast Taiwan Travel Features Archived March 3, 2016, at the Wayback Machine , Government Information Office, Republic of China (Taiwan), December 27, 2006
  6. ↑ Park, Alice (January 25, 2010). "Scientist David Ho: The Man Who Could Beat AIDS". Time . Archived from the original on June 4, 2011. Retrieved January 24, 2010.
  7. ↑ (N. Engl. J. Med. 1995; Science 1996)
  8. 1 2 3 4 Ho, David (August 17, 1995). "Time to Hit HIV, Early and Hard" . New England Journal of Medicine . 333 (7): 450–451. doi:10.1056/NEJM199508173330710. PMID   7616996. Archived from the original on September 1, 2015. Retrieved January 29, 2023. ... zidovudine was shown in 1990 to slow the clinical progression to AIDS in infected but asymptomatic subjects. However, a follow-up of those subjects found no evidence of longer survival with the use of zidovudine...
  9. ↑ Mahungu, Tabitha; Rodger, Alison; Johnson, Margaret (April 1, 2009). "HIV as a chronic disease". Clinical Medicine . 9 (2): 125–128. doi:10.7861/clinmedicine.9-2-125. PMC   4952661 . PMID   19435115. Archived from the original on July 23, 2020. Retrieved January 31, 2023.
  10. 1 2 "David Ho, The Chinese American Hero Who Pioneered Drug Therapies For HIV/AIDS". USAonRACE.
  11. ↑ "About Us - Aaron Diamond AIDS Research Center (ADARC)". Aaron Diamond AIDS Research Center . September 17, 2020. Archived from the original on June 8, 2023. Retrieved October 27, 2023.
  12. 1 2 "Our Legacy - Aaron Diamond AIDS Research Center (ADARC)". Aaron Diamond AIDS Research Center . September 17, 2020. Archived from the original on June 8, 2023. Retrieved October 27, 2023. ...joined Columbia University Irving Medical Center on January 1, 2020. Dr. David Ho remains as the Center's Director and has been named the Clyde and Helen Wu Professor of Medicine at Columbia University.
  13. ↑ "Vagelos College of Physicians and Surgeons - Columbia University Irving Medical Center". Columbia University College of Physicians and Surgeons . December 29, 2020. Archived from the original on June 7, 2023. Retrieved October 27, 2023.
  14. ↑ "Caltech Commencement Program" (PDF). Caltech Campus Publications. June 14, 1974. Retrieved March 29, 2013.
  15. ↑
  16. 1 2 3 4 5 6 "MEMBERS | Committee of 100". www.committee100.org. Committee of 100. Archived from the original on July 2, 2022. Retrieved February 25, 2020.
  17. ↑ (Nature 1997)
  18. ↑
    • "Interviews - David Ho - The Age Of Aids - Frontline". Frontline. PBS. May 30, 2006. Archived from the original on March 7, 2007. Retrieved January 29, 2023. ... if you start to combine the drugs and try to force the virus into a corner using multiple drugs, it is exceedingly difficult or statistically improbable for HIV to become resistant to all the drugs simultaneously.
    • "The Age of AIDS, Part II". Frontline . Season 24 (2006). Episode 11. May 31, 2006. Event occurs at 0:18:54. PBS . Retrieved January 31, 2023. ... However, if you start to combine the drugs and try to force the virus into a corner using multiple drugs, it is exceedingly difficult...for HIV to become resistant to all the drugs simultaneously. 
  19. ↑ Gulick, Roy M.; Mellors, John W.; Havlir, Diane; Eron, Joseph J.; Gonzalez, Charles; McMahon, Deborah; Richman, Douglas D.; Valentine, Fred T.; Jonas, Leslie; Meibohm, Anne; Emini, Emilio A.; Chodakewitz, Jeffrey A.; Deutsch, Paul; Holder, Daniel; Schleif, William A.; Condra, Jon H. (1997). "Treatment with Indinavir, Zidovudine, and Lamivudine in Adults with Human Immunodeficiency Virus Infection and Prior Antiretroviral Therapy". New England Journal of Medicine. 337 (11): 734–739. doi: 10.1056/NEJM199709113371102 . PMID   9287228.
  20. ↑ "The Age of AIDS, Part II". Frontline . Season 24 (2006). Episode 11. May 31, 2006. Event occurs at 0:21:50. PBS . Retrieved January 31, 2023. International AIDS Conference 1996 in Vancouver showing combination therapy results
  21. ↑ "Interviews - David Ho - The Age Of Aids - Frontline". Frontline. PBS. May 30, 2006. Archived from the original on March 7, 2007. Retrieved January 29, 2023. ... response with combination therapy was rather dramatic...we see some deathly ill patients totally recover after two to three weeks of good therapy...people got out of their deathbed after a few weeks of therapy.
  22. ↑ (Nature 1995; Science 1996)
  23. ↑ "COVID-19: Are We Close to a Novel Coronavirus Vaccine?". March 4, 2020.
  24. 1 2 Time, Person of the Year: 75th Anniversary Celebration, Special Collector's Edition, Time Books, 2002, p. 108.
  25. ↑ "1996 Man of the Year". Time Magazine Person of the Year. Time Magazine. Archived from the original on January 23, 2001.
  26. ↑ Gorman, Christine (December 30, 1996). "Dr. David Ho: The Disease Detective". Time . Archived from the original on December 12, 2022. Retrieved February 1, 2023.
  27. ↑ "Golden Plate Awardees of the American Academy of Achievement". www.achievement.org. American Academy of Achievement. Archived from the original on December 21, 2022. Retrieved January 31, 2023.
  28. ↑ "David Ho Interview -- Academy of Achievement". www.achievement.org. American Academy of Achievement. Archived from the original on April 29, 2007.
  29. ↑ Time Millennium, Collector's Edition, Time Inc. Specials, p. 21.
  30. ↑ “Science as a Candle of Hope" David Ho Caltech Commencement Address in 1997
  31. ↑ "AIDS researcher David Ho to be MIT commencement speaker". MIT News. February 16, 1998.
  32. ↑ "The White House - President Clinton Awards the Presidential Citizens Medals Monday, January 8, 2001". Clinton White House. National Archives and Records Administration. January 8, 2001. Archived from the original on August 1, 2012.
  33. ↑ Mo, Steven (June 13, 2011). "AIDS Research Pioneer, David Hoe, Talks To Asian Scientist Magazine". Asian Scientist.
  34. ↑ "California Hall of Fame - California Museum". www.californiamuseum.org. Archived from the original on August 4, 2012. Retrieved January 31, 2023.
  35. ↑ "Distinguished Alumni". Caltech Alumni Association. Archived from the original on May 2, 2020.
  36. ↑ "2017 Portrait of a Nation Prize Recipient: Dr. David Ho". National Portrait Gallery Smithsonian Institution . November 14, 2017. Archived from the original on November 19, 2017. Retrieved January 31, 2023.
  37. ↑ "Ernst Jung Prize". Archived from the original on May 16, 2022. Retrieved January 31, 2023.
  38. ↑ "David D. Ho, MD - Aaron Diamond AIDS Research Center (ADARC)". www.adarc.cuimc.columbia.edu. Aaron Diamond AIDS Research Center. September 11, 2020. Archived from the original on January 7, 2023. Retrieved January 31, 2023.
  39. ↑ ":: David Ho | Architect of Peace". www.architectsofpeace.org. Archived from the original on April 18, 2010.
  40. ↑ "2014 Distinguished Research Career Award | College of Veterinary Medicine - Center for Retrovirus Research". vet.osu.edu. Archived from the original on September 7, 2015. Retrieved January 31, 2023.
  41. ↑ "Board of Trustees - Caltech Academic Catalog". California Institute of Technology. Archived from the original on September 7, 2022. Retrieved January 31, 2023.
  42. ↑ "Former Corporation Members - The MIT Corporation". corporation.mit.edu. Archived from the original on November 6, 2022. Retrieved January 31, 2023.
  43. ↑ "The Announcement for the Prince Mahidol Award 2013". Prince Mahidol Award Foundation. November 21, 2013.
  44. ↑ "Hamdan Award for Medical Research Excellence - Immunity to David Ho" . Retrieved October 22, 2023.
  45. ↑ "David Ho Credits His Achievements to Late Father｜Culture｜News｜WantChinaTimes.com". www.adarc.org. Archived from the original on August 1, 2012. Retrieved February 25, 2020.
  46. ↑ "David D. Ho, MD". Infectious Diseases. May 11, 2020. Retrieved January 11, 2025.
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