Grape therapy or grape diet, also known as ampelotherapy, is a diet that involves heavy consumption of grapes, including seeds, and parts of the vine, including leaves, that is a form of alternative medicine. The concept was developed in 19th-century Germany in spas such as Bad Duerkheim and Merano. [1] The concept has no scientific basis and is regarded as quackery by scientific institutions like the American Cancer Society. [2]
An assumption of some of grape therapy is that consuming grape constituents would provide unusual therapeutic or nutritional benefits. However, consuming grapes has unknown effects against cardiovascular diseases and other diseases, such as metabolic syndrome. [3] Alternative medicine practitioners have recommended grapes and parts of the vine for treating various diseases, but there is no clinical evidence for any such effects. [2] [3]
Grape pomace contains various micronutrients, [4] but the resulting flour from pomace has variable nutrient contents due to processing, drying, and storage conditions. [5] Raw grapes are mostly devoid of nutritional benefit, except for moderate amounts of carbohydrates and vitamin K (see grape nutrition).
Proanthocyanidins, anthocyanins and resveratrol extracted from grape seeds and grape skins are under basic research for their possible biological effects. [3] Pomace also contains organic acids (tartaric, malic, citric, tannic), [4] but there is no evidence for health effects from these phytochemicals. [3]
The documentation of a grape diet was first seen in a publication by Dr. Veit Kaufmann, a family docter in the viticultural city of Bad Duerkheim, Germany, called "Die Traubenkur in Dürkheim a.d. Haardt" (The Grape Treatment Course in Duerkheim at Haardt River) (1856). [1] Kaufmann was well known locally, and a personal friend of Rudolph Virchow, who underwent the treatment regularly.
In the USSR, the principles of a grape cure were developed in the 1920s by a group of physicians of the Semashko Institute (Yalta), headed by A.V. D'iakov. [6] Ampelotherapy is offered in alternative medicine clinics and spas, particularly in Europe, [7] together with vinotherapy, a cosmetic treatment that involves rubbing grapes into the skin.
Johanna Brandt, a South African author, popularized the grape diet as a treatment for cancer from 1925. She published about twenty pamphlets on the subject of natural remedies for health problems with her book The Grape Cure, which is said to have been written after Brandt had cured herself of stomach cancer by following the diet. [8] The book was republished in 1989 as How to Conquer Cancer, Naturally, including an endorsement of Brandt's work by Benedict Lust, who is commonly referred to as "the father of naturopathy".
Although commonly used as a dietary supplement and studied in human trials at an amount much higher than can be consumed from drinking red wine, there is no high-quality evidence that resveratrol provides any benefits for cardiovascular risk factors. [9] Advocates of grape therapy argue that grape phytochemicals inhibit the development of cancer, arthritis or diabetes, but there is no scientific evidence for such effects. [2] [3]
The diet proposed by Veit Kaufmann recommended the consumption of several pounds of freshly picked grapes a day, spread over 4 portions, combined with walks, sports and light healthy meals, over a course of three to six weeks in a spa, overseen by medical personnel. [1] The diet proposed by Johanna Brandt recommended fasting for two or three days, consuming only cold water, followed by a diet of only grapes and water for one to two weeks, with seven meals a day. Fresh fruits, tomatoes, and sour milk or cottage cheese are then introduced to the diet followed by raw vegetables. [2]
Available scientific evidence does not support claims that a diet of grapes is effective for treating cancer or any other disease. [2] The Brandt diet, in particular, has been described as "quackery" by Barrett who notes that the American Cancer Society reviewed The Grape Cure in 1965, 1971, 1974, and 2000 and found no evidence of benefit against human cancer or any other disease. [2] Grape seed extract has been identified by the U.S. Food and Drug Administration as a "fake cancer 'cure'". [10]
Amygdalin is a naturally occurring chemical compound found in many plants, most notably in the seeds (kernels) of apricots, bitter almonds, apples, peaches, cherries and plums, and in the roots of manioc.
A grape is a fruit, botanically a berry, of the deciduous woody vines of the flowering plant genus Vitis. Grapes are a non-climacteric type of fruit, generally occurring in clusters.
A macrobiotic diet is an unconventional restrictive diet based on ideas about types of food drawn from Zen Buddhism. The diet tries to balance the supposed yin and yang elements of food and cookware. Major principles of macrobiotic diets are to reduce animal products, eat locally grown foods that are in season, and consume meals in moderation.
Quackery, often synonymous with health fraud, is the promotion of fraudulent or ignorant medical practices. A quack is a "fraudulent or ignorant pretender to medical skill" or "a person who pretends, professionally or publicly, to have skill, knowledge, qualification or credentials they do not possess; a charlatan or snake oil salesman". The term quack is a clipped form of the archaic term quacksalver, derived from Dutch: kwakzalver a "hawker of salve" or rather somebody who boasted about their salves, more commonly known as ointments. In the Middle Ages the term quack meant "shouting". The quacksalvers sold their wares at markets by shouting to gain attention.
Orthomolecular medicine is a form of alternative medicine that claims to maintain human health through nutritional supplementation. It is rejected by evidence-based medicine. The concept builds on the idea of an optimal nutritional environment in the body and suggests that diseases reflect deficiencies in this environment. Treatment for disease, according to this view, involves attempts to correct "imbalances or deficiencies based on individual biochemistry" by use of substances such as vitamins, minerals, amino acids, trace elements and fatty acids. The notions behind orthomolecular medicine are not supported by sound medical evidence, and the therapy is not effective for chronic disease prevention; even the validity of calling the orthomolecular approach a form of medicine has been questioned since the 1970s.
Resveratrol (3,5,4′-trihydroxy-trans-stilbene) is a stilbenoid, a type of natural phenol or polyphenol and a phytoalexin produced by several plants in response to injury or when the plant is under attack by pathogens, such as bacteria or fungi. Sources of resveratrol in food include the skin of grapes, blueberries, raspberries, mulberries, and peanuts.
The Mediterranean diet is a concept first invented in 1975 by the American biologist Ancel Keys and chemist Margaret Keys. The diet took inspiration from the supposed eating habits and traditional food typical of Crete, much of the rest of Greece, and southern Italy, and formulated in the early 1960s. It is distinct from Mediterranean cuisine, which covers the actual cuisines of the Mediterranean countries, and from the Atlantic diet of northwestern Spain and Portugal. While inspired by a specific time and place, the "Mediterranean diet" was later refined based on the results of multiple scientific studies.
Phytochemicals are chemical compounds produced by plants, generally to help them resist fungi, bacteria and plant virus infections, and also consumption by insects and other animals. The name comes from Greek φυτόν (phyton) 'plant'. Some phytochemicals have been used as poisons and others as traditional medicine.
Chromotherapy, sometimes called color therapy, colorology or cromatherapy, is an alternative medicine that is considered pseudoscience and quackery. Chromotherapists claim to be able to use light in the form of color to balance "energy" lacking from a person's body, whether it be on physical, emotional, spiritual, or mental levels. For example, they thought that shining a colored light on a person would cure constipation. Historically chromotherapy has been associated with mysticism and occultism.
Max Gerson was a German-born American physician who developed the Gerson therapy, a dietary-based alternative cancer treatment that he claimed could cure cancer and most chronic, degenerative diseases. Gerson therapy involves a plant-based diet with coffee enemas, ozone enemas, dietary supplements and raw calf liver extract, the latter was discontinued in the 1980s after patients were hospitalized for bacterial infections.
A healthy diet is a diet that maintains or improves overall health. A healthy diet provides the body with essential nutrition: fluid, macronutrients such as protein, micronutrients such as vitamins, and adequate fibre and food energy.
Johanna Budwig was a German biochemist, alternative cancer treatment advocate and writer. Budwig was a pharmacist and held doctorate degrees in physics and chemistry. Based on her research on fatty acids she developed a lacto-vegetarian diet that she believed was useful in the treatment of cancer. There is no clinical evidence that the Budwig diet is effective, and it may cause adverse effects.
Nutritional genomics, also known as nutrigenomics, is a science studying the relationship between human genome, human nutrition and health. People in the field work toward developing an understanding of how the whole body responds to a food via systems biology, as well as single gene/single food compound relationships. Nutritional genomics or Nutrigenomics is the relation between food and inherited genes, it was first expressed in 2001.
The health effects of wine are mainly determined by its active ingredient – alcohol. Preliminary studies found that drinking small quantities of wine, particularly of red wine, may be associated with a decreased risk of cardiovascular diseases, cognitive decline, stroke, diabetes mellitus, metabolic syndrome, and early death. Other studies found no such effects.
Megavitamin therapy is the use of large doses of vitamins, often many times greater than the recommended dietary allowance (RDA) in the attempt to prevent or treat diseases. Megavitamin therapy is typically used in alternative medicine by practitioners who call their approach orthomolecular medicine. Vitamins are useful in preventing and treating illnesses specifically associated with dietary vitamin shortfalls, but the conclusions of medical research are that the broad claims of disease treatment by advocates of megavitamin therapy are unsubstantiated by the available evidence. It is generally accepted that doses of any vitamin greatly in excess of nutritional requirements will result either in toxicity or in the excess simply being metabolised; thus evidence in favour of vitamin supplementation supports only doses in the normal range. Critics have described some aspects of orthomolecular medicine as food faddism or even quackery. Research on nutrient supplementation in general suggests that some nutritional supplements might be beneficial, and that others might be harmful; several specific nutritional therapies are associated with an increased likelihood of the condition they are meant to prevent.
Orthopathy or natural hygiene (NH) is a set of alternative medical beliefs and practices originating from the Nature Cure movement. Proponents claim that fasting, dieting, and other lifestyle measures are all that is necessary to prevent and treat disease.
A bioactive compound is a compound that has an effect on a living organism, tissue or cell, usually demonstrated by basic research in vitro or in vivo in the laboratory. While dietary nutrients are essential to life, bioactive compounds have not been proved to be essential – as the body can function without them – or because their actions are obscured by nutrients fulfilling the function.
The Immune Power Diet is a pseudoscientific elimination diet promoted by physician Stuart M. Berger (1953–1994). The diet was based on the false idea that many people have hidden food allergies and that by eliminating certain foods and taking dietary supplements the body's immune system would be strengthened.
Nutritional immunology is a field of immunology that focuses on studying the influence of nutrition on the immune system and its protective functions. Indeed, every organism will under nutrient-poor conditions "fight" for the precious micronutrients and conceal them from invading pathogens. As such, bacteria, fungi, plants secrete for example iron chelators (siderophores) to acquire iron from their surrounding
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