MED4

MED4
Identifiers
Aliases	MED4 , ARC36, DRIP36, HSPC126, TRAP36, VDRIP, mediator complex subunit 4
External IDs	OMIM: 605718 MGI: 1914631 HomoloGene: 8568 GeneCards: MED4
Gene location (Human) Chr. Chromosome 13 (human) [1] Band 13q14.2 Start 48,053,323 bp [1] End 48,095,131 bp [1]
Gene location (Mouse) Chr. Chromosome 14 (mouse) [2] Band 14|14 D3 Start 73,747,465 bp [2] End 73,756,289 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in palpebral conjunctiva germinal epithelium rectum monocyte gastric mucosa left coronary artery gastrocnemius muscle skin of abdomen right coronary artery subcutaneous adipose tissue Top expressed in interventricular septum morula abdominal wall primitive streak medial ganglionic eminence secondary oocyte medullary collecting duct otic placode yolk sac renal corpuscle More reference expression data BioGPS More reference expression data
Gene ontology Molecular function thyroid hormone receptor binding protein binding transcription coregulator activity nuclear receptor coactivator activity vitamin D receptor binding signaling receptor activity Cellular component core mediator complex membrane nucleus mediator complex nucleoplasm Biological process regulation of transcription by RNA polymerase II positive regulation of transcription, DNA-templated androgen receptor signaling pathway intracellular steroid hormone receptor signaling pathway regulation of transcription, DNA-templated transcription by RNA polymerase II transcription, DNA-templated transcription initiation from RNA polymerase II promoter Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 29079 67381 Ensembl ENSG00000136146 ENSMUSG00000022109 UniProt Q9NPJ6 Q9CQA5 RefSeq (mRNA) NM_014166 NM_001270629 NM_026119 RefSeq (protein) NP_001257558 NP_054885 NP_080395 Location (UCSC) Chr 13: 48.05 – 48.1 Mb Chr 14: 73.75 – 73.76 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Med4
Identifiers
Symbol	Med4
Pfam	PF10018
InterPro	IPR019258
Available protein structures: Pfam   structures / ECOD   PDB RCSB PDB; PDBe; PDBj PDBsum structure summary

Mediator of RNA polymerase II transcription subunit 4 also known as mediator complex subunit 4 (MED4), a component of Mediator or vitamin D3 receptor-interacting protein complex 36 kDa component (DRIP36) is a protein that in humans is encoded by the MED4 gene. ^{[5] [6] [7]}

Function

The protein encoded by this gene is a component of the vitamin D receptor-interacting protein (DRIP) complex which functions as a nuclear receptor coactivator. The DRIP complex is capable of activating nuclear receptors in a ligand-dependent manner. ^[6]

Interactions

MED4 has been shown to interact with MED25. ^[8]

References

1. GRCh38: Ensembl release 89: ENSG00000136146 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000022109 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. "Entrez Gene: MED4 mediator of RNA polymerase II transcription, subunit 4 homolog (S. cerevisiae)".
6. Rachez C, Lemon BD, Suldan Z, Bromleigh V, Gamble M, Näär AM, Erdjument-Bromage H, Tempst P, Freedman LP (April 1999). "Ligand-dependent transcription activation by nuclear receptors requires the DRIP complex". Nature. 398 (6730): 824–8. Bibcode:1999Natur.398..824R. doi:10.1038/19783. PMID   10235266. S2CID   204992765.
7. Zhang QH, Ye M, Wu XY, Ren SX, Zhao M, Zhao CJ, Fu G, Shen Y, Fan HY, Lu G, Zhong M, Xu XR, Han ZG, Zhang JW, Tao J, Huang QH, Zhou J, Hu GX, Gu J, Chen SJ, Chen Z (October 2000). "Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells". Genome Research. 10 (10): 1546–60. doi:10.1101/gr.140200. PMC   310934 . PMID   11042152.
8. Tomomori-Sato C, Sato S, Parmely TJ, Banks CA, Sorokina I, Florens L, Zybailov B, Washburn MP, Brower CS, Conaway RC, Conaway JW (Feb 2004). "A mammalian mediator subunit that shares properties with Saccharomyces cerevisiae mediator subunit Cse2" (PDF). J. Biol. Chem. 279 (7): 5846–51. doi: 10.1074/jbc.M312523200 . PMID   14638676.

Further reading

• Conaway JW, Florens L, Sato S, Tomomori-Sato C, Parmely TJ, Yao T, Swanson SK, Banks CA, Washburn MP, Conaway RC (2005). "The mammalian Mediator complex". FEBS Lett. 579 (4): 904–8. doi:10.1016/j.febslet.2004.11.031. PMID   15680972. S2CID   45924145.
• Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID   8125298.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID   9373149.
• Ito M, Yuan CX, Malik S, Gu W, Fondell JD, Yamamura S, Fu ZY, Zhang X, Qin J, Roeder RG (1999). "Identity between TRAP and SMCC complexes indicates novel pathways for the function of nuclear receptors and diverse mammalian activators". Mol. Cell. 3 (3): 361–70. doi: 10.1016/S1097-2765(00)80463-3 . PMID   10198638.
• Rachez C, Lemon BD, Suldan Z, Bromleigh V, Gamble M, Näär AM, Erdjument-Bromage H, Tempst P, Freedman LP (1999). "Ligand-dependent transcription activation by nuclear receptors requires the DRIP complex". Nature. 398 (6730): 824–8. Bibcode:1999Natur.398..824R. doi:10.1038/19783. PMID   10235266. S2CID   204992765.
• Näär AM, Beaurang PA, Zhou S, Abraham S, Solomon W, Tjian R (1999). "Composite co-activator ARC mediates chromatin-directed transcriptional activation". Nature. 398 (6730): 828–32. Bibcode:1999Natur.398..828N. doi:10.1038/19789. PMID   10235267. S2CID   23646963.
• Malik S, Gu W, Wu W, Qin J, Roeder RG (2000). "The USA-derived transcriptional coactivator PC2 is a submodule of TRAP/SMCC and acts synergistically with other PCs". Mol. Cell. 5 (4): 753–60. doi: 10.1016/S1097-2765(00)80254-3 . PMID   10882111.
• Zhang QH, Ye M, Wu XY, Ren SX, Zhao M, Zhao CJ, Fu G, Shen Y, Fan HY, Lu G, Zhong M, Xu XR, Han ZG, Zhang JW, Tao J, Huang QH, Zhou J, Hu GX, Gu J, Chen SJ, Chen Z (2001). "Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells". Genome Res. 10 (10): 1546–60. doi:10.1101/gr.140200. PMC   310934 . PMID   11042152.