Oropouche orthobunyavirus

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Oropouche orthobunyavirus
Virus classification OOjs UI icon edit-ltr.svg
(unranked): Virus
Realm: Riboviria
Kingdom: Orthornavirae
Phylum: Negarnaviricota
Class: Ellioviricetes
Order: Bunyavirales
Family: Peribunyaviridae
Genus: Orthobunyavirus
Species:
Oropouche orthobunyavirus

Oropouche orthobunyavirus (OROV) is one of the most common orthobunyaviruses. When OROV infects humans, it causes a rapid fever illness called Oropouche fever. OROV was originally reported in Trinidad and Tobago in 1955 from the blood sample of a fever patient and from a pool of Coquillettidia venezuelensis mosquitoes [1] . In 1960, OROV was isolated from a sloth ( Bradypus tridactylus ) and a pool of Ochlerotatus serratus mosquitoes in Brazil. [2] The virus is considered a public health threat in tropical and subtropical areas of Central and South America, with over half a million infected people as of 2005. [3] OROV is considered to be an arbovirus due to the method of transmission by the mosquitoes Aedes serratus and Culex quinquefasciatus among sloths, marsupials, primates, and birds.

Contents

Epidemic sites

The virus causes Oropouche fever, an urban arboviral disease that has since resulted in >30 epidemics during 1960–2009. [4] Between 1961 and 1980, OROV was reported in the northern state of Pará, Brazil, and from 1980 to 2004, OROV had spread to the Amazonas, Amapá, Acre, Rondônia, Tocantins, and Maranhão. [3]

Virology

OROV belongs to the Peribunyaviridae family of arboviruses. [5] OROV is a single-stranded, negative sense RNA virus. [6] [7] There are no specific ultrastructural studies of the oropouche virus in human tissues that have been recorded to this date. [5] It is likely that this virus shares similar morphological characteristics with other members of the Orthobunyavirus genus. [5] Members of the Orthobunyavirus genus have a three part, single-stranded, negative sense RNA genome of small (S), medium (M) and large (L) RNA segments [8] . These segments function to encode nucleocapsids, glycoproteins and the RNA polymerase in that sequential order. [5] Through phylogenetic analysis of nucleocapsid genes in different oropouche virus strains, it has been revealed that there are three unique genotypes (I, II, III) which have been spreading through Central and South America. [5]

Genomic reassortment

Reassortment is said to be one of the most important mechanisms in explaining the viral biodiversity in orthobunyaviruses. [5] This occurs when two genetically related viruses infect the same cell at the same time forming a progeny virus and this virus holds various components of genetic L, M and S segments from the two parental viruses. [5] In reassortment, the S and L segments are usually exchanged between species further, the S segment, that is coded by the nucleocapsid protein, and the L polymerase function together to create a replication of the viral genome. Hence, one segment will restrict the molecular evolution of another segment and this is said to be inherited as a pair. [5] On the contrary, the M segment codes for viral glycoproteins and these could be more prone to mutations due to a higher selective pressure in their coding region because these proteins are major host range determinants. [5]

Genotypes

As of 2011, based on the small segment (SRNA) genetic information, there were 4 major genotypes (I–IV) of OROV. Genotype I was isolated from strains in Acre, Amazonas, Maranhão, Tocantins, Pará, Trinidad, and Tobago. Genotype II was obtained during the spread in Amapá, Pará, Rondônia, and Peru. Genotype III was isolated from samples in Acre, Minas Gerais, Panama, and Rondônia. The final genotype IV was isolated from Amazonas. [2]

Transmission and dispersion

OROV is considered to be an arbovirus due to the method of transmission by the mosquitoes Aedes serratus and Culex quinquefasciatus among sloths, marsupials, primates, and birds. [9]

A possible dispersal could be predicted for the four genotypes based on time-scaled analysis and epidemiologic data association. Genotype I possibly dispersed towards western Pará, Trinidad, and Tobago. Afterwards, genotype I progressed towards Amazonas, Acre, Maranhão, and Tocantins. Genotype II possibly emerged in Amapá, Pará, Rondônia, and Peru at the same time. Genotype III emerged in Rondônia, moved towards Panama, Acre, and Maranhão. From Maranhão, the genotype progressed towards Minas Gerais. Finally, genotype IV emerged from the city of Manaus and Amazonas. [4]

Experimentation and research

OROV has been used extensively in testing with HeLa cells to study how it induces apoptosis. It was found that OROV causes apoptosis by DNA fragmentation. In UV-inactivated OROV, virus-receptor binding was not enough and that viral uncoating and replication were needed to induce apoptosis. [10]

Related Research Articles

<i>Bunyavirales</i> Order of RNA viruses

Bunyavirales is an order of segmented negative-strand RNA viruses with mainly tripartite genomes. Member viruses infect arthropods, plants, protozoans, and vertebrates. It is the only order in the class Ellioviricetes. The name Bunyavirales derives from Bunyamwera, where the original type species Bunyamwera orthobunyavirus was first discovered. Ellioviricetes is named in honor of late virologist Richard M. Elliott for his early work on bunyaviruses.

Bwamba orthobunyavirus (BWAV) belongs to the genus Orthobunyavirus and the order Bunyavirales RNA viruses. BWAV is present in large parts of Africa, endemic in Mozambique, Tanzania and Uganda. It is transmitted to humans through mosquito bites and results in a brief benign generalised infection with headache, skin rash, diarrhea and joint pain and lasts 4–5 days. The animal reservoir of the virus includes birds, monkeys and donkeys.

<span class="mw-page-title-main">Oropouche fever</span> Medical condition

Oropouche fever is a tropical viral infection which can infect humans. It is transmitted by biting midges and mosquitoes, from a natural reservoir which includes sloths, non-human primates, and birds. The disease is named after the region where it was first discovered and isolated in 1955, by the Oropouche River in Trinidad and Tobago. Oropouche fever is caused by the Oropouche virus (OROV), of the Bunyavirales order of viruses.

<i>Andes orthohantavirus</i> Species of virus

Andes orthohantavirus (ANDV), a species of Orthohantavirus, is a major causative agent of hantavirus cardiopulmonary syndrome (HCPS) and hantavirus pulmonary syndrome (HPS) in South America. It is named for the Andes mountains of Chile and Argentina, where it was first discovered. Originating in the reservoir of rodents, Andes orthohantavirus is easily transmitted to humans who come into contact with infected rodents or their fecal droppings. However, infected rodents do not appear ill, so there is no readily apparent indicator to determine whether the rodent is infected or not. Additionally, Andes orthohantavirus, specifically, is the only hantavirus that can be spread by human to human contact via bodily fluids or long-term contact from one infected individual to a healthy person.

<i>Orthobunyavirus</i> Genus of viruses

Orthobunyavirus is a genus of the Peribunyaviridae family in the order Bunyavirales. There are currently ~170 viruses recognised in this genus. These have been assembled into 103 species and 20 serogroups.

Bunyamwera orthobunyavirus (BUNV) is a negative-sense, single-stranded enveloped RNA virus. It is assigned to the Orthobunyavirus genus, in the Bunyavirales order.

Mayaro virus disease is a mosquito-borne zoonotic pathogen endemic to certain humid forests of tropical South America. Infection with Mayaro virus causes an acute, self-limited dengue-like illness of 3–5 days' duration. The causative virus, abbreviated MAYV, is in the family Togaviridae, and genus Alphavirus. It is closely related to other alphaviruses that produce a dengue-like illness accompanied by long-lasting arthralgia. It is only known to circulate in tropical South America.

Dabie bandavirus, also called SFTS virus, is a tick-borne virus in the genus Bandavirus in the family Phenuiviridae, order Bunyavirales. The clinical condition it caused is known as severe fever with thrombocytopenia syndrome (SFTS). SFTS is an emerging infectious disease that was first described in northeast and central China 2009 and now has also been discovered in Japan, South Korea, Vietnam and Taiwan in 2015. SFTS has a fatality rate of 12% and as high as over 30% in some areas. The major clinical symptoms of SFTS are fever, vomiting, diarrhea, multiple organ failure, thrombocytopenia, leukopenia and elevated liver enzyme levels. Another outbreak occurred in East China in the early half of 2020.

<i>Schmallenberg orthobunyavirus</i> Species of virus

Schmallenberg orthobunyavirus, also called Schmallenberg virus, abbreviated SBV, is a virus that causes congenital malformations and stillbirths in cattle, sheep, goats, and possibly alpaca. It appears to be transmitted by midges, which are likely to have been most active in causing the infection in the Northern Hemisphere summer and autumn of 2011, with animals subsequently giving birth from late 2011. Schmallenberg virus falls in the Simbu serogroup of orthobunyaviruses. It is considered to be most closely related to the Sathuperi and Douglas viruses.

<i>Banna virus</i> Species of virus

Banna virus (BAV) is a virus belonging to Reoviridae, a family of segmented, non-enveloped, double-stranded RNA viruses. It is an arbovirus, being primarily transmitted to humans from the bite of infected mosquitoes of the genus Culex. Pigs and cattle have also been shown to become infected. The most common symptom of infection is fever, but in some cases encephalitis may occur. There is no specific treatment for infection, so treatment is aimed at alleviating the severity of symptoms until the immune system has cleared the infection.

Tahyna orthobunyavirus ("TAHV") is a viral pathogen of humans classified in the California encephalitis virus (CEV) serogroup of the Orthobunyavirus family in the order Bunyavirales, which is endemic to Europe, Asia, Africa and possibly China.

Batai orthobunyavirus (BATV) is a RNA virus belonging to order Bunyavirales, genus Orthobunyavirus.

Cache Valley orthobunyavirus (CVV) is a member of the order Bunyavirales, genus Orthobunyavirus, and serogroup Bunyamwera, which was first isolated in 1956 from Culiseta inornata mosquitos collected in Utah's Cache Valley. CVV is an enveloped arbovirus, nominally 80–120 nm in diameter, whose genome is composed of three single-stranded, negative-sense RNA segments. The large segment of related bunyaviruses is approximately 6800 bases in length and encodes a probable viral polymerase. The middle CVV segment has a 4463-nucleotide sequence and the smallest segment encodes for the nucleocapsid, and a second non-structural protein. CVV has been known to cause outbreaks of spontaneous abortion and congenital malformations in ruminants such as sheep and cattle. CVV rarely infects humans, but when they are infected it has caused encephalitis and multiorgan failure.

<span class="mw-page-title-main">2003 in Brazil</span>

Events in the year 2003 in Brazil.

<span class="mw-page-title-main">1999 in Brazil</span>

Events in the year 1999 in Brazil.

<span class="mw-page-title-main">1995 in Brazil</span>

Events in the year 1995 in Brazil.

<span class="mw-page-title-main">1997 in Brazil</span>

Events in the year 1997 in Brazil.

Jamestown Canyon encephalitis is an infectious disease caused by the Jamestown Canyon virus, an orthobunyavirus of the California serogroup. It is mainly spread during the summer by different mosquito species in the United States and Canada.

Maguari orthobunyavirus, abbreviated MAGV, is a negative-sense, single-stranded RNA virus in the Bunyavirales order, genus Orthobunyavirus, Bunyamwera serogroup, that has been shown to be capable of causing human disease. MAGV is related to Cache Valley virus and Tensaw virus.

Ngari virus (NRIV) is a single-stranded, negative sense, tri-segmented RNA virus. It is a subtype of the Bunyamwera virus (BUNV) and closely related to the Batai virus (BATV). NRIV is the only reassortment virus of the subtypes. There is evidence suggesting that NRIV stems from a naturally occurring reassortment event in which a host was infected with both BUNV and BATV. It is commonly found in areas that experience an outbreak of Rift Valley fever virus (RVFV)

References

  1. https://www.researchsquare.com/article/rs-5098470/v1
  2. 1 2 Vasconcelos, Helena Baldez; Nunes, Márcio R.T.; Casseb, Lívia M.N.; Carvalho, Valéria L.; Pinto da Silva, Eliana V.; Silva, Mayra; Casseb, Samir M.M.; Vasconcelos, Pedro F.C. (2011). "Molecular Epidemiology of Oropouche Virus, Brazil". Emerging Infectious Diseases. 17 (5): 800–806. doi:10.3201/eid1705.101333. ISSN   1080-6040. PMC   3321770 . PMID   21529387.
  3. 1 2 Nunes, Marcio Roberto Teixeira; et al. (2005). "Oropouche virus isolation, southeast Brazil". Emerging Infectious Diseases. 11 (10): 1610–1613. doi:10.3201/eid1110.050464. PMC   3366749 . PMID   16318707.
  4. 1 2 Vasconcelos, Helena Baldez; Nunes, Márcio R.T.; Casseb, Lívia M.N.; Carvalho, Valéria L.; Pinto Da Silva, Eliana V.; Silva, Mayra; Casseb, Samir M.M.; Vasconcelos, Pedro F.C. (2011). "Molecular Epidemiology of Oropouche Virus, Brazil". Emerging Infectious Diseases. 17 (5): 800–806. doi:10.3201/eid1705.101333. PMC   3321770 . PMID   21529387 . Retrieved 2013-04-08.
  5. 1 2 3 4 5 6 7 8 9 Travassos da Rosa, Jorge Fernando; de Souza, William Marciel; Pinheiro, Francisco de Paula; Figueiredo, Mário Luiz; Cardoso, Jedson Ferreira; Acrani, Gustavo Olszanski; Nunes, Márcio Roberto Teixeira (2017-05-03). "Oropouche Virus: Clinical, Epidemiological, and Molecular Aspects of a Neglected Orthobunyavirus". The American Journal of Tropical Medicine and Hygiene. 96 (5): 1019–1030. doi:10.4269/ajtmh.16-0672. ISSN   0002-9637. PMC   5417190 . PMID   28167595.
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  9. Mourao, Maria Paula G.; et al. (2009). "Oropouche Fever Outbreak, Manaus, Brazil, 2007–2008". Emerging Infectious Diseases. 15 (12): 2063–2064. doi:10.3201/eid1512.090917. PMC   3044544 . PMID   19961705.
  10. Acrani, Gustavo Olszanski; Gomes, Rogério; Proença-Módena, José Luiz; da Silva, Andrei Furlan; Oliveira Carminati, Patricia; Silva, Maria Lucia; Santos, Rodrigo Ivo Marques; Arruda, Eurico (2010). "Apoptosis induced by Oropouche virus infection in HeLa cells is dependent on virus protein expression". Virus Research. 149 (1): 56–63. doi: 10.1016/j.virusres.2009.12.013 . ISSN   0168-1702. PMID   20080135.