Outer nuclear layer

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Outer nuclear layer
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Section of retina. (Outer nuclear layer labeled at right, fourth from the bottom.)
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Plan of retinal neurons. (Outer nuclear layer labeled at left, third from the bottom.)
Details
Identifiers
Latin stratum nucleare externum retinae
TA A15.2.04.012
FMA 58684
Anatomical terminology

The outer nuclear layer (or layer of outer granules or external nuclear layer), is one of the layers of the vertebrate retina, the light-detecting portion of the eye. Like the inner nuclear layer, the outer nuclear layer contains several strata of oval nuclear bodies; they are of two kinds, viz.: rod and cone granules, so named on account of their being respectively connected with the rods and cones of the next layer.

Retina light-sensitive organ in the eye

The retina is the innermost, light-sensitive layer of tissue of the eye of most vertebrates and some molluscs. The optics of the eye create a focused two-dimensional image of the visual world on the retina, which translates that image into electrical neural impulses to the brain to create visual perception, the retina serving a function analogous to that of the film or image sensor in a camera.

Inner nuclear layer

The inner nuclear layer or layer of inner granules, of the retina, is made up of a number of closely packed cells, of which there are three varieties, viz.: bipolar cells, horizontal cells, and amacrine cells.

Contents

Rod granules

The spherical rod granules are much the more numerous, and are placed at different levels throughout the layer.

Their nuclei present a peculiar cross-striped appearance, and prolonged from either extremity of each cell is a fine process; the outer process is continuous with a single rod of the layer of rods and cones; the inner ends in the outer plexiform layer in an enlarged extremity, and is imbedded in the tuft into which the outer processes of the rod bipolar cells break up.

In its course it presents numerous varicosities.

Cone granules

The stem-like cone granules, fewer in number than the rod granules, are placed close to the membrana limitans externa, through which they are continuous with the cones of the layer of rods and cones.

They do not present any cross-striation, but contain a pyriform nucleus, which almost completely fills the cell.

From the inner extremity of the granule a thick process passes into the outer plexiform layer, and there expands into a pyramidal enlargement or foot plate, from which are given off numerous fine fibrils, that come in contact with the outer processes of the cone bipolars.

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Neuropil

Neuropil is any area in the nervous system composed of mostly unmyelinated axons, dendrites and glial cell processes that forms a synaptically dense region containing a relatively low number of cell bodies. The most prevalent anatomical region of neuropil is the brain which, although not completely composed of neuropil, does have the largest and highest synaptically-concentrated areas of neuropil in the body. For example, the neocortex and olfactory bulb both contain neuropil.

Rod cell

Rod cells are photoreceptor cells in the retina of the eye that can function in less intense light than the other type of visual photoreceptor, cone cells. Rods are usually found concentrated at the outer edges of the retina and are used in peripheral vision. On average, there are approximately 92 million rod cells in the human retina. Rod cells are more sensitive than cone cells and are almost entirely responsible for night vision. However, rods have little role in color vision, which is the main reason why colors are much less apparent in dim light, and not at all at night.

Cone cell

Cone cells, or cones, are photoreceptor cells in the retinas of vertebrate eyes. They respond differently to light of different wavelengths, and are thus responsible for color vision and function best in relatively bright light, as opposed to rod cells, which work better in dim light. Cone cells are densely packed in the fovea centralis, a 0.3 mm diameter rod-free area with very thin, densely packed cones which quickly reduce in number towards the periphery of the retina. There are about six to seven million cones in a human eye and are most concentrated towards the macula. The commonly cited figure of six million cone cells in the human eye was found by Osterberg in 1935. Oyster's textbook (1999) cites work by Curcio et al. (1990) indicating an average close to 4.5 million cone cells and 90 million rod cells in the human retina.

Retina bipolar cell

As a part of the retina, bipolar cells exist between photoreceptors and ganglion cells. They act, directly or indirectly, to transmit signals from the photoreceptors to the ganglion cells.

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A myelocyte is a young cell of the granulocytic series, occurring normally in bone marrow.

Inner plexiform layer

The inner plexiform layer is an area of the retina that is made up of a dense reticulum of fibrils formed by interlaced dendrites of retinal ganglion cells and cells of the inner nuclear layer. Within this reticulum a few branched spongioblasts are sometimes embedded.

Layer of rods and cones

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The external limiting membrane is one of the ten distinct layers of the retina of the eye. It has a network-like structure and is situated at the bases of the rods and cones.

Outer plexiform layer

The outer plexiform layer is a layer of neuronal synapses in the retina of the eye. It consists of a dense network of synapses between dendrites of horizontal cells from the inner nuclear layer, and photoreceptor cell inner segments from the outer nuclear layer. It is much thinner than the inner plexiform layer, where amacrine cells synapse with retinal ganglion cells.

Retinal nerve fiber layer fibers of the optic nerve

The retinal nerve fiber layer (RNFL) or nerve fiber layer, stratum opticum, is formed by the expansion of the fibers of the optic nerve; it is thickest near the optic disc, gradually diminishing toward the ora serrata.

Ganglion cell layer

The ganglion cell layer is a layer of the retina that consists of retinal ganglion cells and displaced amacrine cells.

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Endoneurium

The endoneurium is a layer of delicate connective tissue around the myelin sheath of each myelinated nerve fiber in the peripheral nervous system. Its component cells are called endoneurial cells. The endoneuria with their enclosed nerve fibers are bundled into groups called nerve fascicles, each fascicle within its own protective sheath called a perineurium. In sufficiently large nerves multiple fascicles, each with its blood supply and fatty tissue, may be bundled within yet another sheath, the epineurium.

Membrana granulosa

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Gastric mucosa

The gastric mucosa is the mucous membrane layer of the stomach, which contains the glands and the gastric pits. In humans, it is about 1 mm thick, and its surface is smooth, soft, and velvety. It consists of simple columnar epithelium, lamina propria, and the muscularis mucosae.

The theca externa is the outer layer of the theca folliculi. It is derived from connective tissue, the cells resembling fibroblasts, and contains abundant collagen. During ovulation, the surge in luteinizing hormone increases cAMP which increases progesterone and PGF2α production. The PGF2α induces the contraction of the smooth muscle cells of the theca externa, increasing intrafollicular pressure. This aids in rupture of the mature oocyte, or immature oocyte at the germinal vesicle stage in the canine, along with plasmin and collagenase degradation of the follicle wall.

Mammalian eye

Mammals normally have a pair of eyes. Although mammalian vision is not so excellent as bird vision, it is at least dichromatic for most of mammalian species, with certain families possessing a trichromatic color perception.

References

This article incorporates text in the public domain from page 1016 of the 20th edition of Gray's Anatomy (1918)

The public domain consists of all the creative works to which no exclusive intellectual property rights apply. Those rights may have expired, been forfeited, expressly waived, or may be inapplicable.

<i>Grays Anatomy</i> English-language textbook of human anatomy

Gray's Anatomy is an English language textbook of human anatomy originally written by Henry Gray and illustrated by Henry Vandyke Carter. Earlier editions were called Anatomy: Descriptive and Surgical, Anatomy of the Human Body and Gray's Anatomy: Descriptive and Applied, but the book's name is commonly shortened to, and later editions are titled, Gray's Anatomy. The book is widely regarded as an extremely influential work on the subject, and has continued to be revised and republished from its initial publication in 1858 to the present day. The latest edition of the book, the 41st, was published in September 2015.