Peptidyl-dipeptidase B

Last updated
Peptidyl-dipeptidase B
Identifiers
EC no. 3.4.15.4
CAS no. 147014-93-5
Databases
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum
Search
PMC articles
PubMed articles
NCBI proteins

Peptidyl-dipeptidase B (EC 3.4.15.4, dipeptidyl carboxyhydrolase, atriopeptin convertase, atrial di-(tri)peptidyl carboxyhydrolase, peptidyldipeptidase B, atrial dipeptidyl carboxyhydrolase, atrial peptide convertase) is an enzyme. [1] [2] [3] [4] It catalyses the following chemical reaction

Release of a C-terminal dipeptide or exceptionally a tripeptide

This membrane-bound, zinc metallopeptidase is located in mammalian atrial myocytes.

References

  1. ↑ Harris RB, Wilson IB (September 1984). "Atrial tissue contains a metallo dipeptidyl carboxyhydrolase not present in ventricular tissue: partial purification and characterization". Archives of Biochemistry and Biophysics. 233 (2): 667–75. doi:10.1016/0003-9861(84)90493-4. PMID   6385859.
  2. ↑ Harris RB, Wilson IB (1985). "Conversion of atriopeptin II to atriopeptin I by atrial dipeptidyl carboxy hydrolase". Peptides. 6 (3): 393–6. doi:10.1016/0196-9781(85)90102-0. PMID   2999723.
  3. ↑ Soler DF, Harris RB (July 1988). "Continuous fluorogenic substrates for atrial dipeptidyl carboxyhydrolase. Importance of Ser in the P1 position". International Journal of Peptide and Protein Research. 32 (1): 35–40. doi:10.1111/j.1399-3011.1988.tb00923.x. PMID   3146555.
  4. ↑ Soler DF, Harris RB (1989). "Atrial dipeptidyl carboxyhydrolase is a zinc-metallo proteinase which possesses tripeptidyl carboxyhydrolase activity". Peptides. 10 (1): 63–8. doi:10.1016/0196-9781(89)90077-6. PMID   2501770.
This page is based on this Wikipedia article
Text is available under the CC BY-SA 4.0 license; additional terms may apply.
Images, videos and audio are available under their respective licenses.