Pyrimidine oxygenase

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Pyrimidine oxygenase
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EC no. 1.14.99.46
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Pyrimidine oxygenase (EC 1.14.99.46, RutA) is an enzyme with systematic name uracil,FMNH2:oxygen oxidoreductase (uracil hydroxylating, ring-opening). [1] [2] This enzyme catalyses the following chemical reaction

(1) uracil + FMNH2 + O2 (Z)-3-ureidoacrylate peracid + FMN
(2) thymine + FMNH2 + O2 (Z)-2-methylureidoacrylate peracid + FMN

In vitro the product (Z)-3-ureidoacrylate peracid is spontaneously reduced to ureidoacrylate.

Related Research Articles

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Dihydroorotate dehydrogenase (DHODH) is an enzyme that in humans is encoded by the DHODH gene on chromosome 16. The protein encoded by this gene catalyzes the fourth enzymatic step, the ubiquinone-mediated oxidation of dihydroorotate to orotate, in de novo pyrimidine biosynthesis. This protein is a mitochondrial protein located on the outer surface of the inner mitochondrial membrane (IMM). Inhibitors of this enzyme are used to treat autoimmune diseases such as rheumatoid arthritis.

In enzymology, a dihydrouracil oxidase (EC 1.3.3.7) is an enzyme that catalyzes the chemical reaction

<span class="mw-page-title-main">4-Hydroxyphenylacetate 3-monooxygenase</span> Class of enzymes

4-hydroxyphenylacetate 3-monooxygenase (EC 1.14.14.9) is an enzyme that catalyzes the chemical reaction

In enzymology, an alkanal monooxygenase (FMN-linked) (EC 1.14.14.3) is an enzyme that catalyzes the chemical reaction

In enzymology, an alkanesulfonate monooxygenase (EC 1.14.14.5) is an enzyme that catalyzes the chemical reaction

In enzymology, a pyrimidine-deoxynucleoside 1'-dioxygenase (EC 1.14.11.10) is an enzyme that catalyzes the chemical reaction

<span class="mw-page-title-main">Cob(II)yrinic acid a,c-diamide reductase</span>

In enzymology, a cob(II)yrinic acid a,c-diamide reductase is an enzyme that catalyzes the chemical reaction

In enzymology, a 2-nitropropane dioxygenase (EC 1.13.11.32) is an enzyme that catalyzes the chemical reaction

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<span class="mw-page-title-main">Sulfur oxygenase/reductase</span>

In enzymology, a sulfur oxygenase/reductase (EC 1.13.11.55) is an enzyme that catalyzes the chemical reaction

2-Amino-4-deoxychorismate dehydrogenase is an enzyme with systematic name (2S)-2-amino-4-deoxychorismate:FMN oxidoreductase. This enzyme catalyses the following chemical reaction

FMN reductase (NADPH) (EC 1.5.1.38, FRP, flavin reductase P, SsuE) is an enzyme with systematic name FMNH2:NADP+ oxidoreductase. This enzyme catalyses the following chemical reaction:

FMN reductase (NADH) (EC 1.5.1.42, NADH-FMN reductase) is an enzyme with systematic name FMNH2:NAD+ oxidoreductase. This enzyme catalyses the following chemical reaction

<span class="mw-page-title-main">Chlorophyllide-a oxygenase</span> Class of enzymes

Chlorophyllide-a oxygenase (EC 1.14.13.122), chlorophyllide a oxygenase, chlorophyll-b synthase, CAO) is an enzyme with systematic name chlorophyllide-a:oxygen 7-oxidoreductase. This enzyme catalyses the following chemical reactions

Premnaspirodiene oxygenase (EC 1.14.13.121, HPO, Hyoscymus muticus premnaspirodiene oxygenase) is an enzyme with systematic name (-)-vetispiradiene,NADPH:oxygen 2alpha-oxidoreductase. This enzyme catalyses the following chemical reaction

Pentalenene oxygenase (EC 1.14.15.32, Formerly EC 1.14.13.133, PtlI) is an enzyme with systematic name pentalenene,NADPH:oxygen 13-oxidoreductase. This enzyme catalyses the following chemical reaction

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3-hydroxy-9,10-secoandrosta-1,3,5(10)-triene-9,17-dione monooxygenase (EC 1.14.14.12, HsaA) is an enzyme with systematic name 3-hydroxy-9,10-secoandrosta-1,3,5(10)-triene-9,17-dione,FMNH2:oxygen oxidoreductase. This enzyme catalyses the following chemical reaction:

Uracil/thymine dehydrogenase (EC 1.17.99.4, uracil oxidase, uracil-thymine oxidase, uracil dehydrogenase) is an enzyme with systematic name uracil:acceptor oxidoreductase. This enzyme catalyses the following chemical reaction

Peroxyureidoacrylate/ureidoacrylate amidohydrolase (EC 3.5.1.110, RutB) is an enzyme with systematic name (Z)-3-ureidoacrylate peracid amidohydrolase. This enzyme catalyses the following chemical reaction sequences:

References

  1. ↑ Mukherjee T, Zhang Y, Abdelwahed S, Ealick SE, Begley TP (April 2010). "Catalysis of a flavoenzyme-mediated amide hydrolysis". Journal of the American Chemical Society. 132 (16): 5550–1. doi:10.1021/ja9107676. PMC   2873085 . PMID   20369853.
  2. ↑ Kim KS, Pelton JG, Inwood WB, Andersen U, Kustu S, Wemmer DE (August 2010). "The Rut pathway for pyrimidine degradation: novel chemistry and toxicity problems". Journal of Bacteriology. 192 (16): 4089–102. doi:10.1128/JB.00201-10. PMC   2916427 . PMID   20400551.
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