Regional routes are the third category of road in the South African route numbering scheme. They are designated with the letter "R" followed by a three-digit number. They serve as feeders connecting smaller towns to the national and provincial routes. Designation as a regional road does not necessarily imply any particular size of road; they range from gravel roads to multi-lane freeways.
The R43 is a provincial route in the Western Cape province of South Africa which connects Ceres with Gansbaai via Worcester, Botrivier and Hermanus. It is co-signed with the N2 for nine kilometres near Botrivier.
The R45 is a provincial route in Western Cape, South Africa that connects Saldanha with Villiersdorp via Vredenburg, Malmesbury and Paarl. The route is mostly a two-lane wide-shouldered highway, however sections within Paarl and between Vredenburg and Saldanha are dual-carriageways. The R45 is co-signed with the N7 for a short segment north of Malmesbury.
The R302 is a Regional Route in South Africa that connects Bellville with Malmesbury. It covers a distance of 54 kilometres (34 mi) in a north-south direction.
The R303 is a regional route in South Africa that connects Citrusdal with Ceres via the Koue Bokkeveld.
The R310 is a Regional Route in South Africa that connects Muizenberg to the south-west with the R45 between Paarl and Franschhoek to the north-east, via Stellenbosch and Hellshoogte Pass. The section between Muizenberg and Stellenbosch is called Baden Powell Drive.
The R311 is a Regional Route in South Africa that connects the R45 between Malmesbury and Hopefield to the north-west with Riebeek-Kasteel to the south-east.
The R316 is a regional route in the Western Cape province of South Africa that connects Caledon to the northwest with Arniston to the southeast via Bredasdorp and Napier. It runs for 96 kilometres (60 mi) and maintains a south-easterly direction for most of its course.
The R323 is a Regional Route in South Africa that connects Riversdale in the south with Laingsburg in the north.
The R326 is a regional route in the Western Cape province of South Africa that connects Stanford in the south-west to the N2 highway between Caledon and Riviersonderend to the north-east.
The R328 is a Regional Route in Western Cape, South Africa that connects Mossel Bay in the south to Prince Albert in the north via Oudtshoorn.
The R359 is a regional route in the Northern Cape province of South Africa that runs along the south bank of the Orange River from Augrabies Falls through Augrabies and Kakamas to Upington.
The N7 is a national route in South Africa that runs from Cape Town northwards through the West Coast and Namaqualand regions to the Namibian border at Vioolsdrif. After crossing the border, it changes designation to B1 and runs north through Windhoek and the north of Namibia.
The N9 is a national route in South Africa that connects George with the N1 at Colesberg, via Graaff-Reinet and Middelburg.
The R507 is a Regional Route in South Africa.
The R527 is a Regional Route in South Africa.
The R533 is a Regional Route in South Africa.
The R701 is a Regional Route in South Africa.
The R705 is a Regional Route in South Africa.
The R722 is a Regional Route in Free State, South Africa that connects Memel with Harrismith.
R43 near Wolseley 
R101 in Paarl 
N1 in Paarl
R45 near Franschhoek 
