Orthohantavirus is a genus of single-stranded, enveloped, negative-sense RNA viruses in the family Hantaviridae within the order Bunyavirales. Members of this genus may be called orthohantaviruses or simply hantaviruses.
Bunyavirales is an order of segmented negative-strand RNA viruses with mainly tripartite genomes. Member viruses infect arthropods, plants, protozoans, and vertebrates. It is the only order in the class Ellioviricetes. The name Bunyavirales derives from Bunyamwera, where the original type species Bunyamwera orthobunyavirus was first discovered. Ellioviricetes is named in honor of late virologist Richard M. Elliott for his early work on bunyaviruses.
Amur virus (AMRV) is a zoonotic negative-sense single-stranded RNA virus. It may be a member of the genus Orthohantavirus, but it has not be definitively classified as a species and may only be a strain. It has been identified as a causative agent of hemorrhagic fever with renal syndrome.
Sangassou orthohantavirus(SANGV) is single-stranded, negative-sense RNA virus species of the genus Orthohantavirus in the Bunyavirales order. It was first isolated in an African wood mouse in the forest in Guinea, West Africa in 2010. It is named for the village near where the mouse was trapped. It is the first indigenous Murinae-associated African hantavirus to be discovered.
Dobrava-Belgrade orthohantavirus (DOBV), also known as Dobrava virus, is an enveloped, single-stranded, negative-sense RNA virus species of Old World Orthohantavirus. It is one of several species of Hantavirus that is the causative agent of severe Hantavirus hemorrhagic fever with renal syndrome. It was first isolated in 1985 from a yellow-necked mouse found in the village of Dobrava, southeastern Slovenia. It was subsequently isolated in striped field mice in Russia and other parts of Eastern Europe. It has also been found in Germany but the reservoir host there is unknown.
Saaremaa virus is a single-stranded, negative-sense, RNA virus Orthohantavirus that causes a milder form of Hantavirus hemorrhagic fever with renal syndrome. It is a member virus of Dobrava-Belgrade orthohantavirus. It was first isolated from a striped field mouse in Slovakia.
Soochong virus (SOOV) is a zoonotic negative sense single-stranded RNA virus. It may be a member of the genus Orthohantavirus, but it has not be definitively classified as a species and may only be a strain. It is one of four rodent-borne Hantaviruses found in the Republic of Korea. It is the etiologic agent for Hantavirus hemorrhagic fever with renal syndrome (HFRS). The other species responsible for HFRS in Korea are Seoul virus, Haantan virus, and Muju virus.
Muju virus(MUV) is a zoonotic negative-sense single-stranded RNA virus of the genus Orthohantavirus. It is a member virus of Puumala orthohantavirus. It is one of four rodent-borne Hantaviruses found in the Republic of Korea. It is the etiologic agent for Hantavirus hemorrhagic fever with renal syndrome (HFRS). The other species responsible for HFRS in Korea are Seoul orthohantavirus, Hantaan orthohantavirus, and Soochong virus.
Magboi virus (MGBV) is a novel, bat-borne Orthohantavirus discovered in a slit-faced bat trapped near the Magboi Stream in eastern Sierra Leone in 2011. It is a single-stranded, negative sense, RNA virus in the Bunyavirales order.
Tula orthohantavirus, formerly Tula virus, (TULV) is a single-stranded, negative-sense RNA virus species of orthohantavirus first isolated from a European common vole found in Central Russia. It causes Hantavirus hemorrhagic fever with renal syndrome. The Microtus species are also found in North America, Europe, Scandinavia, Slovenia, Asia, and Western Russia. Human cases of Tula orthohantavirus have also been reported in Switzerland and Germany.
Hantaan orthohantavirus (HTNV) is an enveloped, single-stranded, negative-sense RNA virus species of Old World Orthohantavirus. It is the causative agent of Korean hemorrhagic fever in humans. It is named for the Hantan River in South Korea, and in turn lends the name to its genus Orthohantavirus and family Hantaviridae.
Topografov virus is an enveloped, negative-sense RNA virus of the genus Orthohantavirus in the Bunyavirales order. It is the first hantavirus to be isolated from Siberian lemmings found near the Topografov River in the Taymyr Peninsula, Siberia.
Imjin thottimvirus(MJNV) is a single-stranded, enveloped, negative-sense RNA virus of the orthohantavirus genus in the Bunyavirales order. It is a newly identified hantavirus isolated from the lung tissues of Ussuri white-toothed shrews of the species Crocidura lasiura captured near the demilitarized zone in the Republic of Korea during 2004 and 2005.
Khabarovsk virus(KBR) is a orthohantavirus in the Bunyavirales order isolated from Microtus fortis discovered in far-east Russia. It is an enveloped, negative-sense RNA virus.
Catacamas virus is a single-stranded, enveloped novel RNA virus in the genus Orthohantavirus of the order Bunyavirales isolated in Oryzomys couesi near the town of Catacamas in eastern Honduras. It is a member virus of Bayou orthohantavirus.
El Moro Canyon orthohantavirus is a single-stranded, negative sense RNA virus of the genus Orthohantavirus. It is a causative agent of Hantavirus pulmonary syndrome.
Nova virus is a single-stranded, negative-sense, enveloped RNA virus with a trisegmented genome. It is one of the most divergent lineages of the hantavirus group – zoonotic viruses of the family Bunyaviridae. No known human cases of infection have yet been reported
Asama orthohantavirus(ASAV), also called Asama virus, is a single-stranded, enveloped, segmented negative-sense RNA hantavirus. The hantavirus was isolated in Japan from Japanese shrew mole. Hantaviruses harbored by shrews are genetically closer to ASAV than to hantaviruses harbored by rodents. Host-switching may be evident in the future due to the viruses closeness to soricine shrew-borne hantaviruses. The detection of the ASAV was the first hantavirus found to be hosted by members of the family Talpidae, which includes shrew moles. Thoughts on hantavirus evolutionary history has expanded due to the discovery of ASAV.
Serang virus(SERV) is a single-stranded, negative-sense, enveloped, novel RNA orthohantavirus.
Gou virus (GOUV) is a single-stranded, negative-sense, enveloped novel RNA orthohantavirus. It is one of the known hantaviruses responsible for hantavirus hemorrhagic fever with renal syndrome in humans.
