Tocofersolan

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Tocofersolan
Tocophersolan.png
Names
IUPAC name
α-Hydro-ω-{[4-oxo-4-({(2R)-2,5,7,8-tetramethyl-2-[(4R,8R)-4,8,12-trimethyltridecyl]-3,4-dihydro-2H-1-benzopyran-6-yl}oxy)butanoyl]oxy}poly(oxyethylene)
Other names
Tocofersolan; Vitamin E PEG succinate; α-Tocopherol polyethylene glycol succinate (TPGS); Liqui-E
Identifiers
3D model (JSmol)
ChEMBL
ChemSpider
DrugBank
ECHA InfoCard 100.123.651 OOjs UI icon edit-ltr-progressive.svg
EC Number
  • 618-345-6
PubChem CID
UNII
  • InChI=1S/C35H58O6/c1-24(2)12-9-13-25(3)14-10-15-26(4)16-11-20-35(8)21-19-30-29(7)33(27(5)28(6)34(30)41-35)40-32(38)18-17-31(37)39-23-22-36/h24-26,36H,9-23H2,1-8H3 Yes check.svgY
    Key: AOBORMOPSGHCAX-UHFFFAOYSA-N Yes check.svgY
  • InChI=1/C35H58O6/c1-24(2)12-9-13-25(3)14-10-15-26(4)16-11-20-35(8)21-19-30-29(7)33(27(5)28(6)34(30)41-35)40-32(38)18-17-31(37)39-23-22-36/h24-26,36H,9-23H2,1-8H3
    Key: AOBORMOPSGHCAX-UHFFFAOYAU
  • O=C(OCCO)CCC(=O)Oc2c(c(c1OC(CCc1c2C)(C)CCCC(C)CCCC(C)CCCC(C)C)C)C
Properties
(C2H4O)nC33H54O5
Molar mass Variable
Pharmacology
A11HA08 ( WHO )
License data
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
X mark.svgN  verify  (what is  Yes check.svgYX mark.svgN ?)
Tocofersolan
Clinical data
Trade names Vedrop
Other namesTocophersolan (USAN US)
AHFS/Drugs.com UK Drug Information
Legal status
Legal status
  • UK: POM (Prescription only) [1]
  • EU:Rx-only [2]
Identifiers
DrugBank
KEGG
CompTox Dashboard (EPA)
ECHA InfoCard 100.123.651 OOjs UI icon edit-ltr-progressive.svg

Tocofersolan (INN; also known as tocophersolan, tocopherol polyethylene glycol succinate, or TPGS) is a synthetic water-soluble version of vitamin E. Natural forms of vitamin E are fat soluble, but not water-soluble. Tocofersolan is a polyethylene glycol (PEG) derivative of α-tocopherol succinate. The addition of PEG enables water solubility.

Tocofersolan is used as a vitamin E supplement or to treat vitamin E deficiency in individuals who cannot absorb fats due to disease. [3] On 24 July 2009 the European Medicines Agency approved tocofersolan under the trade name Vedrop 50 mg/ml oral solution for the treatment of vitamin E deficiency due to digestive malabsorption in paediatric patients with congenital or hereditary chronic cholestasis, from birth (in term newborns) to 16 or 18 years of age (depending on the region). [4]

Tocofersolan is also used in cosmetics and pharmaceuticals as an antioxidant. [5]

References

  1. ↑ "Vedrop 50 mg/ml oral solution - Summary of Product Characteristics (SmPC)". (emc). 19 June 2019. Retrieved 24 July 2020.
  2. ↑ "Vedrop EPAR". European Medicines Agency (EMA). Archived from the original on 24 July 2020. Retrieved 24 July 2020.
  3. ↑ "Tocophersolan Oral". WebMD.
  4. ↑ "Vedrop Summary of Product Characteristics" (PDF). European Medicines Agency.
  5. ↑ Ash M, Ash I (2004). Handbook of Preservatives. Synapse Info Resources. p. 568. ISBN   1-890595-66-7.
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