Trimerelysin I

Trimerelysin I
Identifiers
EC no.	3.4.24.52
CAS no.	151125-16-5
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
Search PMC articles PubMed articles NCBI proteins

Trimerelysin I (EC 3.4.24.52, Trimeresurus metalloendopeptidase I, hemorrhagic proteinase HR1A, hemorrhagic metalloproteinase HR1A, metalloproteinase HR1A) is an enzyme. ^{[1] [2] [3]} This enzyme catalyses the following chemical reaction

Cleavage of only two bonds His¹⁰-Leu and Ala¹⁴-Leu in the insulin B chain

This endopeptidase is present in the venom of the habu snake ( Trimeresurus flavoviridis ).

References

1. Omori-Satoh T, Sadahiro S (October 1979). "Resolution of the major hemorrhagic component of Trimeresurus flavoviridis venom into two parts". Biochimica et Biophysica Acta (BBA) - Protein Structure. 580 (2): 392–404. doi:10.1016/0005-2795(79)90151-x. PMID   518906.
2. Yamakawa Y, Omori-Satoh T (1988). "The sites of cleavage in oxidized insulin-B chain by a hemorrhagic protease derived from the venom of the habu (Trimeresurus flavoviridis)". Toxicon. 26 (2): 227–31. doi:10.1016/0041-0101(88)90178-x. PMID   3284004.
3. Takeya H, Oda K, Miyata T, Omori-Satoh T, Iwanaga S (September 1990). "The complete amino acid sequence of the high molecular mass hemorrhagic protein HR1B isolated from the venom of Trimeresurus flavoviridis". The Journal of Biological Chemistry. 265 (27): 16068–73. PMID   2398046.

External links

• Trimerelysin+I at the U.S. National Library of Medicine Medical Subject Headings (MeSH)