Nazi Germany performed human experimentation on large numbers of prisoners (including children), largely Jews from across Europe, but also Romani, Sinti, ethnic Poles, Soviet prisoners of war, homosexuals and disabled Germans, in its concentration camps mainly in the early 1940s, during World War II and the Holocaust. Prisoners were forced into participating; they did not willingly volunteer and no consent was given for the procedures. Typically, the experiments resulted in death, trauma, illness, shortening of life, disfigurement, or permanent disability, and as such are considered as examples of medical torture since the participants had to endure mass amounts of pain.
At Auschwitz and other German camps, under the direction of Eduard Wirths, selected inmates were subjected to various hazardous experiments that were designed to help German military personnel in combat situations, develop new weapons, aid in the recovery of military personnel who had been injured, and to advance the racial ideology backed by the Third Reich.[4]Aribert Heim conducted similar medical experiments at Mauthausen. At Buchenwald, Carl Værnet conducted experiments on homosexual prisoners in an attempt to "cure" homosexuality.[5]
After the war, these crimes were tried at what became known as the Doctors' Trial, and the abuses perpetrated led to the development of the Nuremberg Code of medical ethics.[6] During the Nuremberg Trials, 23 Nazi doctors and scientists were tried for the unethical treatment of concentration camp inmates, who were often used as research subjects with fatal consequences. Of those 23, 16 were convicted (15 were convicted for the unethical treatment, while one of them was only convicted of SS membership), 7 were condemned to death, 9 received prison sentences from 10 years to life, and 7 were acquitted.[7]
Before World War II
The Law for the Prevention of Genetically Defective Progeny, passed on 14 July 1933, legalized the involuntary sterilization of persons with diseases claimed to be hereditary: weak-mindedness, schizophrenia, alcohol abuse, insanity, blindness, deafness, and physical deformities. The law was used to encourage growth of the Aryan race through the sterilization of persons who fell under the quota of being genetically defective.[8] 1% of citizens between the age of 17 to 24 had been sterilized within two years of the law passing. Within four years, 300,000 patients had been sterilized.[9] From about March 1941 to about January 1945, sterilization experiments were conducted at Auschwitz, Ravensbrück, and other places by Carl Clauberg.[10] The purpose of these experiments was to develop a method of sterilization which would be suitable for sterilizing millions of people with a minimum of time and effort. These experiments were conducted by means of X-ray, surgery and various drugs. Thousands of victims were sterilized. Aside from its experimentation, the Nazi government sterilized around 400,000 people as part of its compulsory sterilization program.[11] Intravenous injections of solutions speculated to contain iodine and silver nitrate were successful, but had unwanted side effects such as vaginal bleeding, severe abdominal pain, and cervical cancer.[12] Therefore, radiation treatment became the favored choice of sterilization. Specific amounts of exposure to radiation destroyed a person's ability to produce ova or sperm. The radiation was administered through deception. Prisoners were brought into a room and asked to complete forms, which took two to three minutes. In this time, the radiation treatment was administered and, unknown to the prisoners, they were rendered completely sterile. Many suffered severe radiation burns.[13]
Eugen Fischer began sterilization experimentation in German-occupied South West Africa during World War I. A supporter of forced sterilization as a means to prevent the growth of inferior populations and a member of the Nazi Party, Fischer focused his experimentation on mixed-race children in order to justify the Nazi Party's ban on interracial marriage. As a result of Fischer's research in Namibia, Germany prohibited marriages between people of different races in its colonies.[14]
During World War II
Jewish twins were kept alive to be used in Josef Mengele's medical experiments. These children from Auschwitz were liberated by the Red Army in January 1945.
The Luftwaffe performed a series of 360 to 400 experiments at Dachau and Auschwitz, in which hypothermia was induced in 280 to 300 victims.[15][16] These were conducted for the Nazi high command to simulate the conditions the armies suffered on the Eastern Front, as the German forces were ill-prepared for the cold weather they encountered. Many experiments were conducted on captured Russian troops; the Nazis wondered whether their genetics gave them superior resistance to cold.[17] Approximately 100 people are reported to have died as a result of these experiments.[18]
In early 1942, prisoners at Dachau concentration camp were used by Sigmund Rascher in experiments to aid German pilots who had to eject at high altitudes. A low-pressure chamber containing these prisoners was used to simulate conditions at altitudes of up to 20,000m (66,000ft).[19] Of the 200 subjects, 80 died outright, and the others were executed.[17]
Other experiments included: experiments on twins (such as sewing twins together in attempts to create conjoined twins),[20][21][22] an experiment in repeated head injury which drove a boy insane,[23] experiments at Buchenwald where poisons were secretly administered in food,[10] experiments to test the effect of various pharmaceutical preparations on phosphorus burns induced with material from incendiary bombs,[10] experiments at Ravensbrück to investigate the effectiveness of sulfonamide after infection with bacteria such as Clostridium perfringens (the causative agent in gas gangrene) and Clostridium tetani (the causative agent in tetanus),[24][25] experiments conducted to attempt treatments of chemical burns induced by mustard gas and similar compounds,[10] and experiments at Dachau to study various methods of making sea water drinkable.[17][26]
Many of the subjects died as a result of the experiments, while many others were executed after the tests were completed to study the effect post mortem.[27] Those who survived were often left mutilated, suffering permanent disability, weakened bodies, and mental distress.[17][28]
The results of the Dachau freezing experiments have been used in some modern research into the treatment of hypothermia, with at least 45 publications having referenced the experiments since the Second World War.[16] This, together with the recent use of data from Nazi research into the effects of phosgene gas, has proven controversial and presents an ethical dilemma for modern physicians who do not agree with the methods used to obtain this data.[26] Some object on an ethical basis, and others have rejected Nazi research purely on scientific grounds, pointing out methodological inconsistencies. In an often-cited review of the Dachau hypothermia experiments, Berger states that the study has "all the ingredients of a scientific fraud" and that the data "cannot advance science or save human lives."[16]
Several Nazi experimenters were after the war employed by the United States government in Operation Paperclip and later similar efforts.[citation needed]
Japan
Empire of Japan
Japanese Unit 731 Complex that used humans for experimentation for biological and chemical weapons, as well as live vivisections and other experiments
Human subject research in Japan began in World War II. It continued for some years after. Unit 731, a department of the Imperial Japanese Army located near Harbin (then in the puppet state of Manchukuo, in northeast China), experimented on prisoners by conducting vivisections, dismemberments, and bacterial inoculations. It induced epidemics on a very large scale from 1932 onward through the Second Sino-Japanese War.[29] It also conducted biological and chemical weapons tests on prisoners and captured POWs. With the expansion of the empire during World War II, similar units were set up in conquered cities such as Nanjing (Unit 1644), Beijing (Unit 1855), Guangzhou (Unit 8604) and Singapore (Unit 9420). After the war, Supreme Commander of the Occupation Douglas MacArthur gave immunity in the name of the United States to Shiro Ishii and all members of the units in exchange for all of the results of their experiments.[29] The United States blocked Soviet access to this information. The Soviets prosecuted some of the Unit 731 members during its Khabarovsk War Crime Trials.
In November 2006, Doctor Akira Makino confessed to Kyodo news that he had performed surgery and amputations on condemned prisoners, including women and children, in 1944 and 1945 while he was stationed on Mindanao.[30] Most of Makino's victims were Moro Muslims.[31][32][33][34][35] In 2007, Doctor Ken Yuasa testified to The Japan Times and said that he believes that at least 1,000 persons working for the Shōwa regime, including surgeons, conducted surgical research in mainland China.[36]
State of Japan
In incidents throughout the 1950s, former Unit 731 members infected prisoners and mental health patients with deadly diseases.[37] In 1958, a large number of infants were brought to Kobe Medical School and forcibly administered sugar by having needles inserted through their noses and into their stomachs. A tube was inserted into their anuses to determine how the sugar was processed by their digestive systems. Many of the infants experienced diarrhea and anal bleeding. The parents were never informed that their children were being used as test subjects.[38]
The US army and Japanese government they installed refused to help Japanese atomic bomb victims (Hibakusha) and instead collected data on them and took samples of their organs after they died.[39][40] The US military paid Japanese members of Unit 731 to conduct experiments on Japanese people in Japan in 1952, with a Japanese girl dying after multiple Japanese babies were deliberately infected with E. coli bacteria at Nagoya City University Hospital by Jiro Ogawa. Japanese patients at a mental hospital were infected with scrub typhus in 1953–1956 with one of them killing himself to escape the torture and another 9 Japanese patients died of the typhus itself.[41]
Aboriginal Australians
In the 1920s and 1930s, Aboriginal Australians were subject to medical experiments on how they experienced pain and where body measurements and blood samples were forcibly taken. The experiments were motivated by a system of scientific racism and were carried out by researchers from the University of Adelaide. In 2002, the vice chancellor of the university described the experiments as "degrading and in some cases barbarous" and the school issued a formal apology to Aboriginal and Torres Strait Islander groups.[42][43]
Canada has historically carried out unethical medical experiments on indigenous populations in concert with its policies of forced cultural assimilation. In 1933, about 600 Native children from the reserves near Qu'Appelle, Saskatchewan, were enrolled in a trial to test the tuberculosis vaccine. During the course of the trial, in both the control and treatment groups nearly a fifth "died from diseases of poverty, gastroenteritis and pneumonia, as a result of the lethal living conditions on the reserves." Parental consent was not sought for indigenous children, though it was sought for the non-indigenous.[44][45] Between 1942 and 1952, malnourished children from six residential schools were used in experiments without consent or parental notification. They were split into treatment and control groups and denied increases in nutrition, despite the researchers believing malnutrition to be a serious problem in the schools, as they were used to determine whether certain combinations of supplements mitigated problems. Children died, developed anemia, and were in some cases denied dental care previously available to them as they developed cavities and gingivitis. The experiments were run by the Department of Indian Affairs of Canada and directed by Percy Moore and Frederick Tisdall, a former president of the Canadian Paediatric Society.[46] In 2014, the Society released a statement outlining guidelines for community-based participatory research involving Inuit, Métis, and First Nations youth.[47]
From 1946 to 1948 U.S. scientific researchers in Guatemala infected hundreds of mental patients with sexually transmitted diseases (STD). Researchers from the U.S. Public Health Service (PHS) conducted experiments on approximately 1,500 male and female patients housed at Guatemala's National Mental Health Hospital.[48] The scientists injected the patients with gonorrhea and syphilis—and encouraged many of them to pass the disease on to others. The experiments were done in cooperation with the Guatemalan government. The PHS carried out the experiments under the guise of syphilis inoculations. In 2010 these experiments were revealed by Susan Reverby of Wellesley College, who was researching a book on the Tuskegee syphilis experiments. The US Secretary of StateHillary Clinton issued an official apology to Guatemala.[49] President Barack Obama apologized to President Álvaro Colom, who had called these experiments "a crime against humanity".[50]
The Vipeholm experiments were a series of human experiments where patients of Vipeholm Hospital for intellectually disabled in Lund, Sweden, were fed large amounts of sweets to provoke dental caries between 1945 and 1955. The experiments were sponsored both by the sugar industry and dentist community, in an effort to determine whether carbohydrates affected the formation of cavities. The experiments provided extensive knowledge about dental health and resulted in enough empirical data to link the intake of sugar to dental caries.[51] However, today they are considered to have violated the principles of medical ethics.[52]
De-classified documents from The National Archives revealed that during the 20th century, scientists from Porton Down conducted experiments on British and Indian soldiers to test the effects of mustard gas. From 1916 until 1989, more than 20,000 British servicemen were subjected to chemical warfare trials. The experiments on Indian servicemen were conducted in Rawalpindi, British India, during the 1930s and 1940s. It is unclear whether the Indian trial subjects, some of whom were hospitalized by their injuries, were all volunteers.[53][54] In the 1950s, Royal Air Force engineer Ronald Maddison was killed when he was exposed to 200 milligrams of sarin at Porton Down. He had believed that he was testing a cure for the common cold, and in 2004 a High Court judgment ruled that his death was "unlawful".[55][56]
Between 1940 and 1979, the Ministry of Defence secretly dispersed potentially dangerous chemicals and micro-organisms across much of the country to evaluate readiness against a biological attack from the Soviet Union. They dropped zinc cadmium sulfide from airplanes and dispersed it by land to track the spread of fluorescent particles, and also spread E. coli, Bacillus globigii, and Serratia marcescens bacteria.[57]
Since the late 19th century, numerous human experiments were performed in the United States, which were later characterized as unethical. They were often performed illegally, without the knowledge, consent, or informed consent of the test subjects. Examples have included the deliberate infection of people with deadly or debilitating diseases, exposing people to biological and chemical weapons, human radiation experiments, injecting people with toxic and radioactive chemicals, surgical experiments, interrogation/torture experiments, tests involving mind-altering substances, and a wide variety of others. Many of these tests were performed on children and mentally disabled individuals. In many of the studies, a large number of the subjects were poor, racial minorities, and/or prisoners. Often, subjects were sick or disabled people, whose doctors told them that they were receiving "medical treatment". They were used as the subjects of harmful and deadly experiments, without their knowledge or consent. In reaction to this, interest groups and institutions have worked to design policies and oversight to ensure that future human subject research in the United States would be ethical and legal.
During World War II, Fort Detrick in Maryland was the headquarters of US biological warfare experiments. Operation Whitecoat involved the injection of infectious agents into military forces to observe their effects in human subjects.[58]
Public outcry over the discovery of government experiments on human subjects led to numerous congressional investigations and hearings, including the Church Committee, Rockefeller Commission, and Advisory Committee on Human Radiation Experiments, amongst others. These inquiries have not resulted in prosecutions. Not all subjects involved in the trials have been compensated or notified that they were subjects of such trials.
In the 1950s and 1960s, Chester M. Southam injected HeLa cancer cells into healthy individuals, cancer patients, and prison inmates from the Ohio Penitentiary.[59] This experiment raised many bioethical concerns involving informed consent, non-maleficence, and beneficence. Some of Southam's subjects, namely those that already had cancer, were unaware that they were being injected with malignant cells.[60] Additionally, in one of these patients, the cells metastasized to her lymph nodes.[60]
In 1962, the Kefauver-Harris Drug Amendment was passed by the United States Congress. This amendment made changes to the Federal Food Drug & Consumer Act by requiring drug companies to prove both safety and effectiveness of their products. Consequently, drugs were required to have Food and Drug Administration (FDA) approval before being marketed to consumers. Additionally, informed consent became a participation requirement and rules were put into place. This regulation was influenced by the results of 1950 use of thalidomide in Western Europe for pregnant women. They were prescribed the sedative thalidomide, which was inaccurately marketed as a morning sickness treatment. Women gave birth to more than 12,000 infants born with deformities due to effects from the drug in utero.
In the Tuskegee syphilis experiment from 1932 to 1972, the United States Public Health Service contracted with the Tuskegee Institute for a long-term study of syphilis. During the study, more than 600 African-American men were studied who were not told they had syphilis. In an effort to better understand the disease, researchers denied the men access to the known treatment of the antibiotic penicillin. They recorded observations of the effects of the disease over time. Under the impression they were being treated for "bad blood", the participants were given free healthcare by the government.[61] As ineffective treatment was given to the subjects, two-thirds of the group had died by the end of the 40-year experiment. A leak in 1972 led to cessation of the study and severe legal ramifications. It has been widely regarded as the "most infamous biomedical research study in U.S. history".[62] Because of the public outrage, in 1974 Congress passed the National Research Act, to provide for protection of human subjects in experiments. The National Commission for the Protection of Human Subjects of Biomedical and Behavioral Research was established. It was tasked with establishing the boundary between research and routine practice, the role of risk-benefit analysis, guidelines for participation, and the definition of informed consent. Its Belmont Report established three tenets of ethical research: respect for persons, beneficence, and justice.[63]
Project MKUltra—sometimes referred to as the "CIA's mind control program"—was the code name given to an illegal program of experiments on human subjects, designed and undertaken by the United States Central Intelligence Agency (CIA). Experiments on humans were intended to identify and develop drugs and procedures to be used in interrogations and torture, in order to weaken the individual to force confessions through mind control. Organized through the Scientific Intelligence Division of the CIA, the project coordinated with the Special Operations Division of the U.S. Army's Chemical Corps.[64] The program began in the early 1950s, was officially sanctioned in 1953, was reduced in scope in 1964, further curtailed in 1967 and officially halted in 1973.[65] The program engaged in many illegal activities;[66][67][68] in particular it used unwitting U.S. and Canadian citizens as its test subjects, which led to controversy regarding its legitimacy.[66]:74[69][70][71] MKUltra used numerous methodologies to manipulate people's mental states and alter brain functions, including the surreptitious administration of drugs (especially LSD) and other chemicals, hypnosis, sensory deprivation, isolation, verbal and sexual abuse, as well as various forms of torture.[72]
Beecher Paper
In a 1966 paper, Harvard anesthesiologist Henry K. Beecher described 22 published medical studies in which patients had been subjects with no expected benefit to the patient of the experiment.[73] This has been characterized as unethical. For example, patients infused with live cancer cells had been told in one study that they were receiving "some cells", without being told this was cancer. Though identities of the authors and institutions had been stripped, the 22 studies were later identified as having been conducted by mainstream researchers and published in prestigious journals within approximately the previous decade. The 22 cases had been selected from a set of 50 that Beecher had collected. He presented evidence that such unethical studies were widespread and represented a systemic problem in medical research rather than exceptions.[73][74]
Beecher had been writing about human experimentation and publicizing cases that he considered to be bad practice for nearly a decade. His 1965 briefing to science writers and his 1966 paper gained widespread news coverage and stimulated public reaction.[74][75] The paper has been described as "the most influential single paper ever written about experimentation involving human subjects."[76] The United States Office for Human Research Protections credits Beecher through this paper as "ultimately contributing to the impetus for the first NIH and FDA regulations."[77]
Beecher was instrumental in developing solutions to such abuses. He noted that a common element in these studies was that some experimental subjects, such as military personnel or mentally handicapped children in institutions, were not in a position to freely decline consent.[74] Beecher believed that rules requiring informed consent were not alone sufficient, as truly informed consent was an unattainable ideal. He worked both to define the rules and conditions for informed consent, and to establish institutional review boards as an additional layer of oversight regarding research protocols.[74][75]
International drug trials
Since the late 20th century, African nations have often been the sites of clinical testing by large international pharmaceutical companies. In some cases, rural communities have developed iatrophobia (fear of doctors) after undergoing or learning of highly controversial medical experimentation. The fundamental distrust lies in the potential confrontation of Hobson's choice: "Experimental medicine or no medicine at all". Multiple cases of ethically questionable experiments have been documented.[78]
In the late 20th century, Depo-Provera was clinically tested on Zimbabwean women. Once approved, the drug was used as a population control measure in the 1970s. Commercial farm owners put pressure on native women workers to accept the use of Depo-Provera.[79] Population control interests motivated many of the family planning programs. This led to its eventual ban in Zimbabwe.[79]
A 1996 clinical trial in Kano, Nigeria, involving the Pfizer drug Trovan to treat meningitis resulted in 200 children being disabled and the deaths of 11. Because of these casualties, the Nigerian government sued Pfizer over whether it had appropriately obtained informed consent.[80][81] Pfizer argued in court that it had met all regulations for drug testing. Many Nigerians mistrust the use of medical vaccines and also refuse to participate in medical trials.[80]
In 1994 United States drug companies began conducting trials of the drug AZT on HIV-positive African subjects with the goal of developing treatments to reduce the transmission of HIV/AIDS during childbirth.[82] With funding from the National Institutes of Health (NIH) and Centers for Disease Control (CDC), the program tested over 17,000 Zimbabwean women for the efficacy of AZT in preventing transmission of HIV/AIDS during childbirth. Half of the women were given a placebo rather than the drug, and the subjects were not informed of the potential dangers of the treatment. According to Peter Lamptey, the head of the AIDS Control and Prevention Program, "if you interviewed the people in the study, most wouldn't understand to what they had actually consented."[82] An estimated 1000 newborns of women in the study contracted HIV/AIDS, although this could have been avoided by treating the women with known drugs. The testing was ceased in 1998 when the CDC claimed to have obtained sufficient data from experiments in Thailand.[82]
The Nuremberg Code is a set of ethical research principles for human experimentation created by the court in U.S. v Brandt, one of the Subsequent Nuremberg trials that were held after the Second World War.
Project MKUltra was a human experimentation program designed and undertaken by the U.S. Central Intelligence Agency (CIA) to develop procedures and identify drugs that could be used during interrogations to weaken individuals and force confessions through brainwashing and psychological torture.
Informed consent is a principle in medical ethics, medical law, media studies, and other fields, that a person must have sufficient information and understanding before making decisions about accepting risk, such as their medical care. Pertinent information may include risks and benefits of treatments, alternative treatments, the patient's role in treatment, and their right to refuse treatment. In most systems, healthcare providers have a legal and ethical responsibility to ensure that a patient's consent is informed. This principle applies more broadly than healthcare intervention, for example to conduct research, to disclose a person's medical information, or to participate in high risk sporting and recreational activities.
The Tuskegee Study of Untreated Syphilis in the Negro Male was a study conducted between 1932 and 1972 by the United States Public Health Service (PHS) and the Centers for Disease Control and Prevention (CDC) on a group of nearly 400 African American men with syphilis. The purpose of the study was to observe the effects of the disease when untreated, though by the end of the study medical advancements meant it was entirely treatable. The men were not informed of the nature of the experiment, and more than 100 died as a result.
Human subject research is systematic, scientific investigation that can be either interventional or observational and involves human beings as research subjects, commonly known as test subjects. Human subject research can be either medical (clinical) research or non-medical research. Systematic investigation incorporates both the collection and analysis of data in order to answer a specific question. Medical human subject research often involves analysis of biological specimens, epidemiological and behavioral studies and medical chart review studies. On the other hand, human subject research in the social sciences often involves surveys which consist of questions to a particular group of people. Survey methodology includes questionnaires, interviews, and focus groups.
An institutional review board (IRB), also known as an independent ethics committee (IEC), ethical review board (ERB), or research ethics board (REB), is a committee at an institution that applies research ethics by reviewing the methods proposed for research involving human subjects, to ensure that the projects are ethical. The main goal of IRB reviews is to ensure that study participants are not harmed. Such boards are formally designated to approve, monitor, and review biomedical and behavioral research involving humans, and they are legally required in some countries under certain specified circumstances. Most countries use some form of IRB to safeguard ethical conduct of research so that it complies with national and international norms, regulations or codes.
The Stateville Penitentiary malaria study was a controlled but ethically questionable study of the effects of malaria on prisoners of Stateville Penitentiary near Joliet, Illinois, in the 1940s, conducted by the Department of Medicine at the University of Chicago in conjunction with the United States Army and the State Department. The Stateville experiment was viewed as coercive because it offered shortened sentences to participants. The Green report was written in 1945 about it by Andrew Conway Ivy, used in Nuremberg Medical Trial, which affected the Nuremberg Code, and used to discuss how medical experimentation on prisoners should be carried out.
An ethics committee is a body responsible for ensuring that medical experimentation and human subject research are carried out in an ethical manner in accordance with national and international law.
In health care, a clinical trial is a comparison test of a medication or other medical treatment, versus a placebo, other medications or devices, or the standard medical treatment for a patient's condition.
The Office for Human Research Protections (OHRP) is a small office within the United States Department of Health and Human Services (DHHS), specifically the Office of the Assistant Secretary for Health in the Office of the Secretary of DHHS, that deals with ethical oversights in clinical research conducted by the department, mostly through the National Institutes of Health (NIH).
Nazi human experimentation was a series of medical experiments on prisoners by Nazi Germany in its concentration camps mainly between 1942 and 1945. There were 15,754 documented victims, of various nationalities and age groups, although the true number is believed to be more extensive. Many survived, with a quarter of documented victims being killed. Survivors generally experienced severe permanent injuries.
Throughout history, prisoners have been frequent participants in scientific, medical and social human subject research. Some of the research involving prisoners has been exploitative and cruel. Many of the modern protections for human subjects evolved in response to the abuses in prisoner research. Research involving prisoners is still conducted today, but prisoners are now one of the most highly protected groups of human subjects
Holmesburg Prison, given the nickname "The Terrordome," was a prison operated by the city of Philadelphia, Pennsylvania and the Pennsylvania Department of Prisons (PDP) from 1896 to 1995. The facility is located at 8215 Torresdale Avenue in the Holmesburg section of Philadelphia. It was decommissioned in 1995 when it closed. As of today, the structure still stands and is occasionally used for prisoner overflow and work programs.
Numerous experiments which were performed on human test subjects in the United States in the past are now considered to have been unethical, because they were performed without the knowledge or informed consent of the test subjects. Such tests have been performed throughout American history, but have become significantly less frequent with the advent and adoption of various safeguarding efforts. Despite these safeguards, unethical experimentation involving human subjects is still occasionally uncovered.
Human subject research legislation in the United States can be traced to the early 20th century. Human subject research in the United States was mostly unregulated until the 20th century, as it was throughout the world, until the establishment of various governmental and professional regulations and codes of ethics. Notable – and in some cases, notorious – human subject experiments performed in the US include the Tuskegee syphilis experiment, human radiation experiments, the Milgram obedience experiment and Stanford prison experiments and Project MKULTRA. With growing public awareness of such experimentation, and the evolution of professional ethical standards, such research became regulated by various legislation, most notably, those that introduced and then empowered the institutional review boards.
The Guatemala syphilis experiments were United States-led human experiments conducted in Guatemala from 1946 to 1948. The experiments were led by physician John Charles Cutler, who also participated in the late stages of the Tuskegee syphilis experiment. Doctors infected 1,300 people, including at least 600 soldiers and people from various impoverished groups with syphilis, gonorrhea, and chancroid, without the informed consent of the subjects. Only 700 of them received treatment. In total, 5,500 people were involved in all research experiments, of whom 83 died by the end of 1953, though it is unknown whether or not the injections were responsible for all these deaths. Serology studies continued through 1953 involving the same vulnerable populations in addition to children from state-run schools, an orphanage, and rural towns. However, the intentional infection of patients ended with the original study.
John Charles Cutler was a senior surgeon, and the acting chief of the venereal disease program in the United States Public Health Service. He is known for leading several controversial and unethical human experiments of syphilis, done under the auspices of the Public Health Service. He willfully spread syphilis and gonorrhea to unwitting patients including soldiers, prisoners, adults with leprosy, mental patients and orphan children as young as nine in the Guatemala syphilis experiments. He also conducted the Tuskegee syphilis experiments, in which African American men, not informed of the nature of the experiment, were deliberately denied treatment for syphilis.
African countries have been sites for clinical trials by large pharmaceutical companies, raising human rights concerns. Incidents of unethical experimentation, clinical trials lacking properly informed consent, and forced medical procedures have been claimed and prosecuted.
Various organizations have created guidelines for human subject research for various kinds of research involving human subjects and for various situations.
John Friend Mahoney was an American physician best known as a pioneer in the treatment of syphilis with penicillin. He won the 1946 Lasker Award.
↑ Tyebkhan, G (2003). "Declaration of Helsinki: the ethical cornerstone of human clinical research". Indian Journal of Dermatology, Venereology and Leprology. 69 (3): 245–7. PMID17642902.
↑ Mitscherlich, A; Mielke F (1992). "Epilogue: Seven Were Hanged". In Annas GJ; Grodin MA (eds.). The Nazi Doctors And The Nuremberg Code - Human Rights in Human Experimentation. New York: Oxford University Press. pp.105–107.
↑ Gardella, JE (1999). "The cost-effectiveness of killing: an overview of Nazi "euthanasia". Medical Sentinel. 4: 132–5.
↑ Dahl M. [Selection and destruction-treatment of "unworthy-to-live" children in the Third Reich and the role of child and adolescent psychiatry], Prax Kinderpsychol Kinderpsychiatr 2001;50:170-91.
↑ Berenbaum, Michael (1993). The world must know: the history of the Holocaust as told in the United States Holocaust Memorial Museum. Boston: Little, Brown. pp.194–5. ISBN0-316-09134-0.
↑ Gustafsson, BE; Quensel, CE; Lanke, LS; Lundqvist, C; Grahnen, H; Bonow, BE; Krasse, B (1954). "The Vipeholm dental caries study; the effect of different levels of carbohydrate intake on caries activity in 436 individuals observed for five years". Acta Odontologica Scandinavica. 11 (3–4): 232–64. doi:10.3109/00016355308993925. PMID13196991.
↑ Jo Thomas (3 Sep 1977). "C.I.A Says It Found More Secret Papers on Behavior Control: Senate Panel Puts Off Hearing to Study Data Dozen Witnesses Said To Have Misled Inquiry C.I.A. Tells Of Finding Secret Data". New York Times.
1 2 3 Meier, Benjamin Mason: "International Protection of Persons Undergoing Medical Experimentation: Protecting the Right of Informed Consent", Berkeley Journal of International Law [1085-5718] Meier yr:2002 vol:20 iss:3 pg:513 -554
Further reading
Sam Kean (2021). The Icepick Surgeon: Murder, Fraud, Sabotage, Piracy, and Other Dastardly Deeds Perpetrated in the Name of Science. Little, Brown and Company. ISBN978-0-316-49650-6.
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