| Portfolio | Minister | Term |
|---|
| Start | End |
|---|
| Prime Minister | William Lyon Mackenzie King | 23 October 1935 | 15 November 1948 |
| Minister of Agriculture | Vacant (George Barton was acting) | 23 October 1935 | 25 October 1935 |
| Thomas Crerar (acting) | 25 October 1935 | 4 November 1935 |
| James Garfield Gardiner | 4 November 1935 | 15 November 1948 |
| Minister for Canada Mortgage and Housing Corporation | C. D. Howe | 1 January 1946 | 15 November 1948 |
| Minister for the Canadian Wheat Board | William Daum Euler | 23 October 1935 | 9 May 1940 |
| James Angus MacKinnon | 9 May 1940 | 19 January 1948 |
| C. D. Howe | 19 January 1948 | 15 November 1948 |
| Secretary of State for External Affairs | William Lyon Mackenzie King | 23 October 1935 | 4 September 1946 |
| Louis St. Laurent | 4 September 1946 | 10 September 1948 |
| Lester B. Pearson | 10 September 1948 | 15 November 1948 |
| Minister of Finance and Receiver General | Charles Avery Dunning | 23 October 1935 | 6 September 1939 |
| James Ralston | 6 September 1939 | 8 July 1940 |
| James Lorimer Ilsley | 8 July 1940 | 10 December 1946 |
| Douglas Abbott | 10 December 1946 | 15 November 1948 |
| Minister of Fisheries | Joseph-Enoil Michaud | 23 October 1935 | 7 October 1942 |
| Ernest Bertrand | 7 October 1942 | 30 August 1945 |
| Hedley Francis Gregory Bridges | 30 August 1945 | 11 August 1947 |
| Vacant (Stewart Bates was acting) | 11 August 1947 | 14 August 1947 |
| Ernest Bertrand (acting) | 14 August 1947 | 2 September 1947 |
| Milton Fowler Gregg | 2 September 1947 | 19 January 1948 |
| James Angus MacKinnon | 19 January 1948 | 11 June 1948 |
| Robert Wellington Mayhew | 11 June 1948 | 15 November 1948 |
| Minister of Immigration and Colonization | Thomas Crerar | 23 October 1935 | 1 December 1936 |
| Minister of the Interior and Superintendent-General of Indian Affairs | Thomas Crerar | 23 October 1935 | 1 December 1936 |
| Minister responsible for Indian Affairs | Thomas Crerar | 1 December 1936 | 18 April 1945 |
| James Allison Glen | 18 April 1945 | 11 June 1948 |
| James Angus MacKinnon | 11 June 1948 | 15 November 1948 |
| Minister of Justice and Attorney General | Ernest Lapointe | 23 October 1935 | 27 November 1941 |
| Joseph-Enoil Michaud (acting) | 27 November 1941 | 10 December 1941 |
| Louis St. Laurent | 10 December 1941 | 10 December 1946 |
| James Lorimer Ilsley | 10 December 1946 | 1 July 1948 |
| Louis St. Laurent (acting) | 1 July 1948 | 10 September 1948 |
| Louis St. Laurent | 10 September 1948 | 15 November 1948 |
| Minister of Labour | Norman McLeod Rogers | 23 October 1935 | 19 September 1939 |
| Norman Alexander McLarty | 19 September 1939 | 15 December 1941 |
| Humphrey Mitchell | 15 December 1941 | 15 November 1948 |
| Leader of the Government in the House of Commons | Ian Alistair Mackenzie | 18 October 1944 | 1 May 1948 |
| Alphonse Fournier | 1 May 1948 | 15 November 1948 |
| Leader of the Government in the Senate | Raoul Dandurand | 23 October 1935 | 11 March 1942 |
| James Horace King (acting) | 11 March 1942 | 26 May 1942 |
| James Horace King | 26 May 1942 | 25 August 1945 |
| Wishart McLea Robertson | 25 August 1945 | 15 November 1948 |
| Minister of Marine | C. D. Howe | 23 October 1935 | 2 November 1936 |
| Minister of Mines | Thomas Crerar | 23 October 1935 | 1 December 1936 |
| Minister of Mines and Resources | Thomas Crerar | 1 December 1936 | 18 April 1945 |
| James Allison Glen | 18 April 1945 | 11 June 1948 |
| James Angus MacKinnon | 11 June 1948 | 15 November 1948 |
| Minister of Munitions and Supply | C. D. Howe | 9 April 1940 | 1 January 1946 |
| Associate Minister of National Defence | Charles Gavan Power | 12 July 1940 | 27 November 1944 |
| Vacant | 27 November 1944 | 15 November 1948 |
| Minister of National Defence | Ian Alistair Mackenzie | 23 October 1935 | 19 September 1939 |
| Norman McLeod Rogers | 19 September 1939 | 11 June 1940 |
| Charles Gavan Power (acting) | 11 June 1940 | 5 July 1940 |
| James Ralston | 5 July 1940 | 2 November 1944 |
| Andrew McNaughton | 2 November 1944 | 21 August 1945 |
| Douglas Abbott | 21 August 1945 | 12 December 1946 |
| Brooke Claxton | 12 December 1946 | 15 November 1948 |
| Minister of National Defence for Air | Vacant (Charles Gavan Power was acting) | 22 May 1940 | 23 May 1940 |
| Charles Gavan Power | 23 May 1940 | 30 November 1944 |
| Angus Lewis Macdonald (acting) | 30 November 1944 | 11 January 1945 |
| Colin W. G. Gibson (acting) | 11 January 1945 | 8 March 1945 |
| Colin W. G. Gibson | 8 March 1945 | 12 December 1946 |
| Minister of National Defence for Naval Services | Angus Lewis Macdonald | 12 July 1940 | 18 April 1945 |
| Douglas Abbott | 18 April 1945 | 12 December 1946 |
| Minister of National Health and Welfare | Brooke Claxton | 18 October 1944 | 12 December 1946 |
| Paul Martin Sr. | 12 December 1946 | 15 November 1948 |
| Minister of National Revenue | James Lorimer Ilsley | 23 October 1935 | 8 July 1940 |
| Colin W. G. Gibson | 8 July 1940 | 8 March 1945 |
| James Angus MacKinnon (acting) | 8 March 1945 | 19 April 1945 |
| David Laurence MacLaren | 19 April 1945 | 30 July 1945 |
| James Angus MacKinnon (acting) | 30 July 1945 | 29 August 1945 |
| James Joseph McCann | 29 August 1945 | 15 November 1948 |
| Minister of National War Services | James Garfield Gardiner | 12 July 1940 | 11 June 1941 |
| Joseph Thorarinn Thorson | 11 June 1941 | 7 October 1942 |
| Léo Richer Laflèche | 7 October 1942 | 18 April 1945 |
| James Joseph McCann | 18 April 1945 | 19 January 1948 |
| Vacant | 19 January 1948 | 15 November 1948 |
| Minister of Pensions and National Health | Charles Gavan Power | 23 October 1935 | 19 September 1939 |
| Ian Alistair Mackenzie | 19 September 1939 | 18 October 1944 |
| Postmaster General | John Campbell Elliott | 23 October 1935 | 23 January 1939 |
| Norman Alexander McLarty | 23 January 1939 | 19 September 1939 |
| Charles Gavan Power | 19 September 1939 | 23 May 1940 |
| James Lorimer Ilsley (acting) | 23 May 1940 | 8 July 1940 |
| William Pate Mulock | 8 July 1940 | 9 June 1945 |
| Vacant (Walter James Turnbull was acting) | 9 June 1945 | 29 August 1945 |
| Ernest Bertrand | 29 August 1945 | 15 November 1948 |
| President of the Queen's Privy Council | William Lyon Mackenzie King | 23 October 1935 | 15 November 1948 |
| Minister of Public Works | Pierre Joseph Arthur Cardin | 23 October 1935 | 13 May 1942 |
| Joseph-Enoil Michaud (acting) | 13 May 1942 | 7 October 1942 |
| Alphonse Fournier | 7 October 1942 | 15 November 1948 |
| Minister of Railways and Canals | C. D. Howe | 23 October 1935 | 2 November 1936 |
| Minister of Reconstruction | Vacant (C. D. Howe was acting) | 30 June 1944 | 13 October 1944 |
| C. D. Howe | 13 October 1944 | 1 January 1946 |
| Minister of Reconstruction and Supply | C. D. Howe | 1 January 1946 | 15 November 1948 |
| Secretary of State for Canada and Registrar General | Fernand Rinfret | 23 October 1935 | 12 July 1939 |
| Vacant (Ephraim Herbert Coleman was acting) | 12 July 1939 | 26 July 1939 |
| Ernest Lapointe (acting) | 26 July 1939 | 9 May 1940 |
| Pierre-François Casgrain | 9 May 1940 | 15 December 1941 |
| Norman Alexander McLarty | 15 December 1941 | 18 April 1945 |
| Paul Martin Sr. | 18 April 1945 | 12 December 1946 |
| Colin W. G. Gibson | 12 December 1946 | 15 November 1948 |
| Solicitor General | Vacant | 23 October 1935 | 18 April 1945 |
| Joseph Jean | 18 April 1945 | 15 November 1948 |
| Minister of Trade and Commerce | William Daum Euler | 23 October 1935 | 9 May 1940 |
| James Angus MacKinnon | 9 May 1940 | 19 January 1948 |
| C. D. Howe | 19 January 1948 | 15 November 1948 |
| Minister of Transport | C. D. Howe | 2 November 1936 | 8 July 1940 |
| Pierre Joseph Arthur Cardin | 8 July 1940 | 13 May 1942 |
| C. D. Howe (acting) | 13 May 1942 | 6 October 1942 |
| Joseph-Enoil Michaud | 6 October 1942 | 18 April 1945 |
| Lionel Chevrier | 18 April 1945 | 15 November 1948 |
| Minister of Veterans Affairs | Ian Alistair Mackenzie | 18 October 1944 | 19 January 1948 |
| Milton Fowler Gregg | 19 January 1948 | 15 November 1948 |
| Minister without Portfolio | Raoul Dandurand | 23 October 1935 | 11 March 1942 |
| James Angus MacKinnon | 23 January 1939 | 9 May 1940 |
| James Horace King | 26 May 1942 | 25 August 1945 |
| Wishart McLea Robertson | 4 September 1945 | 15 November 1948 |
