Adenain

Adenain
Identifiers
EC no.	3.4.22.39
CAS no.	369652-03-9
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
Search PMC articles PubMed articles NCBI proteins

Adenain (EC 3.4.22.39) is an enzyme. ^{[1] [2] [3]} This enzyme catalyses the following chemical reaction

Cleaves proteins of the adenovirus and its host cell at two consensus sites: -Yaa-Xaa-Gly-Gly-Xaa- and -Yaa-Xaa-Gly-Xaa-Gly- (in which Yaa is Met, Ile or Leu, and Xaa is any amino acid)

This cysteine endopeptidase is encoded by adenoviruses.

References

1. Webster A, Hay RT, Kemp G (January 1993). "The adenovirus protease is activated by a virus-coded disulphide-linked peptide". Cell. 72 (1): 97–104. doi:10.1016/0092-8674(93)90053-s. PMID   8422686.
2. Ding J, McGrath WJ, Sweet RM, Mangel WF (April 1996). "Crystal structure of the human adenovirus proteinase with its 11 amino acid cofactor". The EMBO Journal. 15 (8): 1778–83. doi:10.1002/j.1460-2075.1996.tb00526.x. PMC   450093 . PMID   8617222.
3. Weber, J.M.; Rawlings, N.D.; Woessner, J.F. (1998). "Adenovirus protease". In Barrett, A.J. (ed.). Handbook of Proteolytic Enzymes. London: Academic Press. pp. 741–743.

External links

• Adenain at the U.S. National Library of Medicine Medical Subject Headings (MeSH)