Encofosbuvir

Encofosbuvir

Clinical data
Trade names	英强布韦
Legal status
Legal status	Rx in China
Identifiers
IUPAC name [3-[(2R,3R,4R,5R)-3-fluoro-4-hydroxy-3-methyl-5-[[[[(2S)-1-oxo-1-propan-2-yloxypropan-2-yl]amino]-phenoxyphosphoryl]oxymethyl]oxolan-2-yl]-2,6-dioxopyrimidin-1-yl]methyl (2S)-2-(methoxycarbonylamino)-4-methylsulfanylbutanoate
CAS Number	2232134-77-7
PubChem CID	141522644
UNII	82E4Q8WQV7
Chemical and physical data
Formula	C30H42FN4O13PS
Molar mass	748.71 g·mol−1
3D model (JSmol)	Interactive image
SMILES C[C@]1(F)[C@@H](O[C@H](COP(OC2=CC=CC=C2)(N[C@H](C(OC(C)C)=O)C)=O)[C@H]1O)N3C(=O)N(COC([C@@H](NC(OC)=O)CCSC)=O)C(=O)C=C3
InChI InChI=1S/C30H42FN4O13PS/c1-18(2)46-25(38)19(3)33-49(42,48-20-10-8-7-9-11-20)45-16-22-24(37)30(4,31)27(47-22)34-14-12-23(36)35(29(34)41)17-44-26(39)21(13-15-50-6)32-28(40)43-5/h7-12,14,18-19,21-22,24,27,37H,13,15-17H2,1-6H3,(H,32,40)(H,33,42)/t19-,21-,22+,24+,27+,30+,49-/m0/s1 Key:GAHCKEWMXZYJAZ-VBWBMHESSA-N

Encofosbuvir is an antiviral drug used to treat hepatitis C virus (HCV). In China, encofosbuvir is approved for use in combination with netanasvir for the treatment of adult patients with chronic HCV genotypes 1, 2, 3, or 6, who are either treatment-naive or have been previously treated with interferon. ^[1]

References

1. "Netanasvir Phosphate Capsules Approved for Marketing by China NMPA". National Medical Products Administration. 2025-06-11.