Haplogroup M8

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Haplogroup M8
Possible time of origin34,400 YBP [1]
Possible place of origin East Asia
Ancestor M
DescendantsM8a, CZ
Defining mutationsA4715G C7196a G8584A A15487t T16298C [1]

In human mitochondrial genetics, Haplogroup M8 is a human mitochondrial DNA (mtDNA) haplogroup. [2] [3]

Contents

Origin

Haplogroup M8 is a descendant of haplogroup M. Haplogroup M8 is divided into subclades M8a, C and Z.

Distribution

It is an East Asian haplogroup. Today, haplogroup M8 is found at its highest frequency in indigenous populations of East Siberia such as Evenk and Yukaghir. Haplogroup M8 is one of the most common mtDNA haplogroups among Yakut, Tuvan. Haplogroup C, the most major one of three subclades, is highly distributed among the Amerindian and Indigenous peoples of East Siberia. Haplogroup Z, another one of three subclades, is highly distributed among Even from Kamchatka (8/39 Z1a2a, 3/39 Z1a3, 11/39 = 28.2% Z total). mtDNA Haplogroup M8a, a not well known one of the three subclades, is highly distributed among Northern Han Chinese from Liaoning (16/317 = 5.0%).

Table of Frequencies by ethnic group

PopulationFrequencyCountSourceSubclades
Yakut 0.407378 Pakendorf 2006 C=153, Z=1
Mongolian 0.27747 Jin 2009 M8a=1, C=10, Z=2
Xibe (Xinjiang)0.145137[ citation needed ]C=13, Z=7
Han Chinese (Liaoning)0.120317[ citation needed ]M8a=16, C=14, Z=8
Korean (Chungcheong)0.103117[ citation needed ]-
Han Chinese (Shandong)0.099393[ citation needed ]M8a=8, C=14, Z=17
Han Chinese (Shanghai)0.09751[ citation needed ]M8a=7, C=5, Z=2
Han Chinese (Henan)0.086208[ citation needed ]M8a=9, C=7, Z=2
Korean (Gangwon)0.079114[ citation needed ]-
Manchurian 0.07540 Jin 2009 M8a=1, C=1, Z=1
Korean (Gyeongsang)0.071112[ citation needed ]-
Korean (Seoul)0.067134[ citation needed ]-
Korean (Jeolla)0.059118[ citation needed ]-
Korean (Gwangju)0.03360[ citation needed ]M8a=2
Japanese 0.0321312 Tanaka 2004 M8a=18, C=7, Z=17
Vietnamese 0.02935[ citation needed ]-
Han Chinese (South)0.02678[ citation needed ]-
Korean (Jeju Island)0.009113[ citation needed ]-
Okinawan 0.003326 Umetsu 2005 CZ=1
Taiwan Aboriginal 0.000640 Trejaut 2005 -
Philippines 0.00059 Tajima 2004 -

Subclades

Haplogroup C, the most major one of three subclades is highly distributed among the Amerindian and Indigienous peoples of East Siberia. Haplogroup Z, the other one of three subclades is highly distributed among Even from Kamchatka (8/39 Z1a2a, 3/39 Z1a3, 11/39 = 28.2% Z total), mtDNA Haplogroup M8a, not well known one of three subclades is highly distributed among Northern Han Chinese from Liaoning (16/317 = 5.0%).

Tree

This phylogenetic tree of haplogroup M8 subclades is based on the paper by Mannis van Oven and Manfred Kayser Updated comprehensive phylogenetic tree of global human mitochondrial DNA variation [1] and subsequent published research.

The American figure skater Kristi Yamaguchi is a member of haplogroup M8a. [4]

See also

Phylogenetic tree of human mitochondrial DNA (mtDNA) haplogroups

  Mitochondrial Eve (L)  
L0 L1–6 
L1 L2   L3    L4 L5 L6
M N  
CZ D E G Q   O A S R   I W X Y
C Z B F R0   pre-JT   P   U
HV JT K
H V J T

References

  1. 1 2 3 van Oven, Mannis; Manfred Kayser (13 Oct 2008). "Updated comprehensive phylogenetic tree of global human mitochondrial DNA variation". Human Mutation. 30 (2): E386 –E394. doi: 10.1002/humu.20921 . PMID   18853457. S2CID   27566749.
  2. ↑ "Figure 1 Kaplan-Meier plot of haplogroup D4 and M8. A: Kaplan-Meier..." ResearchGate. Retrieved 2020-01-17.
  3. ↑ "Figure 2: Phylogenetic network of C, Z and M8 HVR1 sequences revealed..." ResearchGate. Retrieved 2020-01-17.
  4. ↑ Gates Jr., Henry Louis (2010). Faces of America: How 12 Extraordinary People Discovered Their Pasts. New York University Press. p. 231.

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