Hexachlorophosphazene

Hexachlorophosphazene

Names
IUPAC name 2,2,4,4,6,6-Hexachloro-1,3,5,2λ5,4λ5,6λ5-triazatriphosphinine
Other names Phosphonitrilic chloride trimer Hexachlorotriphosphazene Hexachlorocyclotriphosphazene Triphosphonitrilic chloride 2,2,4,4,6,6-hexachloro-2,2,4,4,6,6-hexahydro-1,3,5,2,4,6-triazatriphosphorine
Identifiers
CAS Number	940-71-6  Y
3D model (JSmol)	Interactive image
ChEMBL	ChEMBL2022081  Y
ChemSpider	190959  Y
ECHA InfoCard	100.012.160
EC Number	213-376-8
PubChem CID	220225
UNII	7VR28MTM9D  Y
CompTox Dashboard (EPA)	DTXSID4061331
InChI InChI=1S/Cl6N3P3/c1-10(2)7-11(3,4)9-12(5,6)8-10 Y Key: UBIJTWDKTYCPMQ-UHFFFAOYSA-N Y InChI=1/Cl6N3P3/c1-10(2)7-11(3,4)9-12(5,6)8-10 Key: UBIJTWDKTYCPMQ-UHFFFAOYAJ
SMILES N1=P(N=P(N=P1(Cl)Cl)(Cl)Cl)(Cl)Cl
Properties
Chemical formula	(NPCl2)3
Molar mass	347.64 g·mol−1
Appearance	colourless solid
Density	1.98 g/mL at 25 °C
Melting point	112 to 114 °C (234 to 237 °F; 385 to 387 K)
Boiling point	decomposes (above 167 °C)
Sublimation conditions	60 °C at 0.05 Torr
Solubility in water	decomposes
Solubility in carbon tetrachloride	24.5 wt % (20 °C) 35.6 wt % (40 °C) 39.2 wt % (60 °C)
Solubility in cyclohexane	22.3 wt % (20 °C) 36.8 wt % (40 °C) 53.7 wt % (60 °C)
Solubility in xylene	27.7 wt % (20 °C) 38.9 wt % (40 °C) 50.7 wt % (60 °C)
Magnetic susceptibility (χ)	−149×10−6 cm3/mol
Refractive index (nD)	1.62 (589 nm)
Structure
Crystal structure	orthorhombic
Space group	62 (Pnma, D16 2h)
Point group	D3h
Lattice constant	a = 13.87 Å, b = 12.83 Å, c = 6.09 Å
Formula units (Z)	4
Molecular shape	chair (slightly ruffled)
Dipole moment	0 D
Thermochemistry
Std enthalpy of formation (ΔfH⦵298)	−812.4 kJ/mol
Enthalpy of vaporization (ΔfHvap)	55.2 kJ/mol
Enthalpy of sublimation (ΔfHsublim)	76.2 kJ/mol
Hazards
Occupational safety and health (OHS/OSH):
Main hazards	mild irritant
GHS labelling:
Pictograms
Signal word	Danger
Hazard statements	H314
Precautionary statements	P260, P264, P280, P301+P330+P331, P303+P361+P353, P304+P340, P305+P351+P338, P310, P321, P363, P405, P501
Flash point	Non-flammable
Related compounds
Related compounds	Hexafluorophosphazene Poly(dichlorophosphazene) Polyphosphazene Trithiazyl trichloride Tetrasulfur tetranitride Polythiazyl Benzene Borazine
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa). N  verify  (what is  YN ?) Infobox references

Hexachlorophosphazene is an inorganic compound with the chemical formula (N P Cl ₂)₃. The molecule has a cyclic, unsaturated backbone consisting of alternating phosphorus and nitrogen atoms, and can be viewed as a trimer of the hypothetical compound N≡PCl₂ (phosphazyl dichloride). Its classification as a phosphazene highlights its relationship to benzene. ^[1] There is large academic interest in the compound relating to the phosphorus-nitrogen bonding and phosphorus reactivity. ^{[2] [3]}

Occasionally, commercial or suggested practical applications have been reported, too, utilising hexachlorophosphazene as a precursor chemical. ^{[2] [4]} Derivatives of noted interest include the hexalkoxyphosphazene lubricants obtained from nucleophilic substitution of hexachlorophosphazene with alkoxides, ^[4] or chemically resistant inorganic polymers with desirable thermal and mechanical properties known as polyphosphazenes produced from the polymerisation of hexachlorophosphazene. ^{[2] [4]}

Structure and characterisation

Bond lengths and conformation

Hexachlorophosphazene is a cyclic molecule, containing a P₃N₃ core with alternating nitrogen and phosphorus atoms, and two additional chlorine atoms bonded to each phosphorus atom. Hexachlorophosphazene molecule contains six equivalent P–N bonds, for which the adjacent P–N distances are 157 pm. ^{[1] [2] [5]} This is characteristically shorter than the ca. 177 pm P–N bonds in the valence saturated phosphazane analogues. ^[3]

The molecule possesses D_3h symmetry, and each phosphorus center is tetrahedral with a Cl–P–Cl angle of 101°. ^[5]

The P₃N₃ ring in hexachlorophosphazene deviates from planarity and is slightly ruffled (see chair conformation). ^[2] By contrast, the P₃N₃ ring in the related hexafluorophosphazene species is completely planar. ^[2]

Characterisation methods

³¹P-NMR spectroscopy is the usual method for assaying hexachlorophosphazene and its reactions. ^{[6] [7] [8]} Hexachlorophosphazene exhibits a single resonance at 20.6 ppm as all P environments are chemically equivalent. ^{[7] [8]}

In it IR spectrum, the 1370 and 1218 cm⁻¹ vibrational bands are assigned to ν_P–N stretches. ^{[7] [8]} Other bands are found at 860 and 500–600 cm⁻¹, respectively assigned to ring and ν_P–Cl. ^[8]

Hexachlorophosphazene and many of its derivatives have been characterized by single crystal X-ray crystallography. ^{[2] [5]}

Bonding

Depictions of P–N bonding in a general cyclotriphosphazene: left, a representation of alternating single and double P–N bonds (does not account for equal bond lengths), used as a matter of convention; middle, the earlier proposed delocalised ring system (discredited due to infeasibility of P 3d participation ); right, the most accurate description to current knowledge, where the majority of the bonding is ionic

Early analyses

Cyclophosphazenes such as hexachlorophosphazene are distinguished by notable stability and equal P–N bond lengths which, in many such cyclic molecules, would imply delocalization or even aromaticity. To account for these features, early bonding models starting from the mid-1950s invoked a delocalised π system arising from the overlap of N 2p and P 3d orbitals. ^{[2] [3]}

Modern bonding models

Starting from the late 1980s, more modern calculations and the lack of spectroscopic evidence reveal that the P 3d contribution is negligible, invalidating the earlier hypothesis. ^[3] Instead, a charge separated model is generally accepted. ^{[1] [3]}

According to this description, the P–N bond is viewed as a very polarised one (between notional P⁺ and N⁻), with sufficient ionic character to account for most of the bond strength. ^{[1] [3]}

The rest (~15%) of the bond strength may be attributed to a negative hyperconjugation interaction: the N lone pairs can donate some electron density into π-accepting σ* molecular orbitals on the P. ^[3]

Synthesis

The synthesis of hexachlorophosphazene was first reported by von Liebig in 1834. In that report he describes experiments conducted with Wöhler. ^[9] They found that phosphorus pentachloride (PCl₅) and ammonia (NH₃) react exothermically to yield a new substance that could be washed with cold water to remove the ammonium chloride ([NH₄]Cl) coproduct. The new compound contained P, N, and Cl, on the basis of elemental analysis. It was sensitive toward hydrolysis by hot water. ^[2]

Modern syntheses are based on the developments by Schenk and Römer who used ammonium chloride in place of ammonia and inert chlorinated solvents. By replacing ammonia with ammonium chloride allows the reaction to proceed without a strong exothermic reaction associated with the NH₃/PCl₅. Typical chlorocarbon solvents are 1,1,2,2-tetrachloroethane or chlorobenzene, which tolerate the hydrogen chloride (HCl) side product. Since ammonium chloride is insoluble in chlorinated solvents, workup is facilitated. ^{[10] [11]} For the reaction under such conditions, the following stoichiometry applies:

n[NH₄]Cl + n PCl₅ → (NPCl₂)_n + n HCl

where n can usually take values of 2 (the dimer tetrachlorodiphosphazene), 3 (the trimer hexachlorotriphosphazene), and 4 (the tetramer octachlorotetraphosphazene). ^[12]

The three major cyclophosphazene products resulting from the reaction of phosphorus pentachloride and ammonium chloride

Purification by sublimation gives mainly the trimer and tetramer. Slow vacuum sublimation at approximately 60 °C affords the pure trimer free of the tetramer. ^[6] Reaction conditions such as temperature may also be tuned to maximise the yield of the trimer at the expense of the other possible products; nonetheless, commercial samples of hexachlorophosphazene usually contain appreciable amounts of octachlorotetraphosphazene, even up to 40%. ^[6]

Formation mechanism

The mechanism of the above reaction has not been resolved, but it has been suggested that PCl₅ is found in its ionic form [PCl₄]⁺[PCl₆]⁻ (tetrachlorophosphonium hexachlorophosphate(V)) and the reaction proceeds via nucleophilic attack of [PCl₄]⁺ (tetrachlorophosphonium) by NH₃ (from [NH₄]Cl dissociation). ^[2] Elimination of HCl (the major side product) creates a reactive nucleophilic intermediate

NH₃ + [PCl₄]⁺ → HN=PCl₃ + HCl + H⁺

which through further attack of [PCl₄]⁺ and subsequent HCl elimination, creates a growing acyclic intermediate

HN=PCl₃ + [PCl₄]⁺ → [Cl₃P−N=PCl₃]⁺ + HCl

NH₃ + [Cl₃P−N=PCl₃]⁺ → HN=PCl₂−N=PCl₃ + HCl + H⁺, etc.

until an eventual intramolecular attack leads to the formation of one of the cyclic oligomers. ^[2]

Reactions

Substitution at P

Hexachlorophosphazene reacts readily with alkali metal alkoxides and amides. ^{[1] [2]}

A SN2 substitution at hexachlorotriphosphazene. A trigonal bipyramidal transition state is proposed.

The nucleophilic polysubstitution of chloride by alkoxide proceeds via displacement of chloride at separate phosphorus centers: ^[1]

(NPCl₂)₃ + 3 NaOR → (NPCl(OR))₃ + 3 NaCl

(NPCl(OR))₃ + 3 NaOR → (NP(OR)₂)₃ + 3 NaCl

The observed regioselectivity is due to the combined steric effects and oxygen lone pair π-backdonation (which deactivates already substituted P atoms). ^{[1] [2]}

Ring-opening polymerisation

Heating hexachlorophosphazene to ca. 250 °C induces polymerisation. ^{[1] [2] [4] [6]} The tetramer also polymerises in this manner, although more slowly. ^[4] The conversion is a type of ring-opening polymerisation (ROP). ^{[6] [7]} The ROP mechanism is found to be catalysed by Lewis acids, but is overall not very well understood. ^[7] Prolonged heating of the polymer at higher temperatures (ca. 350 °C) will cause depolymerisation. ^[2]

The structure of the inorganic chloropolymer product (Poly(dichlorophosphazene)) comprises a linear –(N=P(−Cl)₂−)_n chain, where n ~ 15000. ^{[2] [4]} It was first observed in the late 19th century and its form after chain cross-linking has been called "inorganic rubber" due to its elastomeric behaviour. ^[4]

Hexachlorotriphosphazene ROP and subsequent nucleophilic substitution for desired polyphosphazene synthesis

This polydichlorophosphazene product is the starting material for a wide class of polymeric compounds, collectively known as polyphosphazenes. Substitution of the chloride groups by other nucleophilic groups, especially alkoxides as laid out above, yields numerous characterised derivatives. ^{[2] [4] [6]}

Lewis basicity

The nitrogen centres of hexachlorophosphazene are weakly basic, and this Lewis base behaviour has been suggested to play a role in the polymerisation mechanism. ^[7] Specifically, hexachlorophosphazene has been reported to form adducts of various stoichiometries with Lewis acids AlCl₃, AlBr₃, GaCl₃, SO₃, TaCl₅, VOCl₃, but no isolable product with BCl₃. ^[7]

Among these, the best structurally characterised are the 1:1 adducts with aluminium trichloride or with gallium trichloride; they are found with the Al/Ga atom bound to a N and assume a more prominently distorted chair conformation compared to the free hexachlorophosphazene. ^[7] The adducts also exhibit fluxional behaviour in solution for temperatures down to −60 °C, which can be monitored with ¹⁵N and ³¹P-NMR. ^[7]

Coupling reagent

Hexachlorophosphazene has also found applications in research by enabling aromatic coupling reactions between pyridine and either N,N-dialkylanilines or indole, resulting in 4,4'-substituted phenylpyridine derivatives, postulated to go through a cyclophosphazene pyridinium salt intermediate. ^[6]

The compound may also be used as a peptide coupling reagent for the synthesis of oligopeptides in chloroform, though for this application the tetramer octachlorotetraphosphazene usually proves more effective. ^[6]

Photochemical degradation

Both the trimer and tetramer in hydrocarbon solutions photochemically react forming clear liquids identified as alkyl-substituted derivatives (NPCl_2−xR_x)_n, where n = 3, 4. ^[6] Such reactions proceed under prolonged UVC (mercury arc) illumination without affecting the P_nN_n rings. Solid films of the trimer and tetramer will not undergo any chemical change under such irradiation conditions. ^[6]

Applications

The hexalkoxyphosphazenes (especially the aryloxy species), resulting from the nucleophilic hexasubstitution of the hexachlorophosphazene P atoms, have attracted interest for their high thermal and chemical stability as well as their low glass transition temperature. ^[4] Certain hexalkoxyphosphazenes (such as the hexa-phenoxy derivative) have been put to commercial use as fireproof materials and high temperature lubricants. ^[4]

Polyphosphazenes obtained from polymerised hexachlorophosphazene (poly(dichlorophosphazene)) have garnered attention within the field of inorganic polymers. The elastomeric and thermoplastic properties have been investigated. ^{[2] [4]} Some of them appear promising for future applications as fibre- or membrane-forming high performance materials, since they combine transparency, backbone flexibility, tunable hydrophilicity or hydrophobicity, and various other desirable properties. ^[4]

Polyphosphazene-based components have been used in O-rings, fuel lines and shock absorbers, where the polyphosphazenes confer fire resistance, imperviousness to oils, and flexibility even at very low temperatures. ^[2]

Further reading

• Discovery of cyclophosphazenes: Liebig-Wöhler, Briefwechsel vol. 1, 63; Ann. Chem. (Liebig), vol. 11 (1834), 146.
• First reports on their polymerisation: H. N. Stokes (1895), On the chloronitrides of phosphorus. American Chemical Journal, vol. 17, p. 275.H. N. Stokes (1896), On Trimetaphosphimic acid and its decomposition products. American Chemical Journal, vol. 18 issue 8, p. 629.
• Example of hexalkoxyphosphazene synthesis from hexachlorophosphazene and structure description: Allcock, Harry R.; Ngo, Dennis C.; Parvez, Masood; Whittle, Robert R.; Birdsall, William J. (1991-03-01). "Syntheses and structures of cyclic and short-chain linear phosphazenes bearing 4-phenylphenoxy side groups". Journal of the American Chemical Society. 113 (7): 2628–2634. doi:10.1021/ja00007a041. ISSN   0002-7863.
• Novel hexalkoxyphosphazene synthesis not starting from hexachlorophosphazene: Ye, Chengfeng; Zhang, Zefu; Liu, Weimin (2002-01-01). "A Novel Synthesis of Hexasubstituted Cyclotriphosphazenes". Synthetic Communications. 32 (2): 203–209. doi:10.1081/SCC-120002003. ISSN   0039-7911. S2CID   97319633.

References

1. Allen, Christopher W. (1991-03-01). "Regio- and stereochemical control in substitution reactions of cyclophosphazenes". Chemical Reviews. 91 (2): 119–135. doi:10.1021/cr00002a002. ISSN   0009-2665.
2. Greenwood, Norman N.; Earnshaw, Alan (1997). Chemistry of the Elements (2nd ed.). Butterworth-Heinemann. ISBN   978-0-08-037941-8.
3. Chaplin, Adrian B.; Harrison, John A.; Dyson, Paul J. (2005-11-01). "Revisiting the Electronic Structure of Phosphazenes". Inorganic Chemistry. 44 (23): 8407–8417. doi:10.1021/ic0511266. ISSN   0020-1669. PMID   16270979.
4. Mark, J. E.; Allcock, H. R.; West, R. “Inorganic Polymers” Prentice Hall, Englewood, NJ: 1992. ISBN   0-13-465881-7.
5. Bartlett, Stewart W.; Coles, Simon J.; Davies, David B.; Hursthouse, Michael B.; i̇Bişogˇlu, Hanife; Kiliç, Adem; Shaw, Robert A.; Ün, İlker (2006). "Structural investigations of phosphorus–nitrogen compounds. 7. Relationships between physical properties, electron densities, reaction mechanisms and hydrogen-bonding motifs of N3P3Cl(6 − n)(NHBu t ) n derivatives". Acta Crystallographica Section B: Structural Science. 62 (2): 321–329. doi: 10.1107/S0108768106000851 . PMID   16552166.
6. Allcock, H. R. (1972). Phosphorus-nitrogen compounds ; cyclic, linear, and high polymeric systems. New York: Academic Press. ISBN   978-0-323-14751-4. OCLC   838102247.
7. Heston, Amy J.; Panzner, Matthew J.; Youngs, Wiley J.; Tessier, Claire A. (2005). "Lewis Acid Adducts of [PCl2N]3". Inorganic Chemistry. 44 (19): 6518–6520. doi:10.1021/ic050974y. PMID   16156607.
8. Dhiman, Nisha; Mohanty, Paritosh (2019-10-28). "A nitrogen and phosphorus enriched pyridine bridged inorganic–organic hybrid material for supercapacitor application". New Journal of Chemistry. 43 (42): 16670–16675. doi:10.1039/C9NJ03976G. ISSN   1369-9261. S2CID   208761169.
9. J. Liebig (1834). "Nachtrag der Redaction". Ann. Pharm. 11: 139–150. doi:10.1002/jlac.18340110202.
10. R. Klement (1963). "Phosphonitrilic Chlorides". In G. Brauer (ed.). Handbook of Preparative Inorganic Chemistry, 2nd Ed. Vol. 1. NY, NY: Academic Press. p. 575.
11. Nielsen, Morris L.; Cranford, Garland (2007) [1960]. "Trimeric Phosphonitrile Chloride and Tetrameric Phosphonitrile Chloride". Inorganic Syntheses. Inorganic Syntheses. Vol. 6. pp. 94–97. doi:10.1002/9780470132371.ch28. ISBN   9780470132371.
12. Holleman, A. F.; Wiberg, E. "Inorganic Chemistry" Academic Press: San Diego, 2001. ISBN   0-12-352651-5.