Highway 5 or the Trans-Samaria Highway, is one of Israel's main highways, connecting the Mediterranean coast immediately north of Tel Aviv with the central Sharon plain and eastwards to Ariel and other Israeli settlements in the northern West Bank.
Highway 90 is the longest Israeli road, at about 480 kilometres (300 mi), and stretches from Metula and the northern border with Lebanon, along the western side of the Sea of Galilee, through the Jordan River Valley, along the Dead Sea's western bank, through the Arabah valley, and until Eilat and the southern border with Egypt on the Red Sea. The central section of the road traverses the Israeli-occupied West Bank. While it passes near the city of Jericho, it runs through Area C and does not enter areas controlled by the Palestinian Authority.
Highway 2 is an Israeli highway located on the coastal plain of the Mediterranean Sea. It begins as a major arterial road within Tel Aviv, becoming a freeway as it exits the city northward, continuing to Haifa. North of Tel Aviv, the highway is also called The Coastal Highway.
Highway 40 is a north-south intercity road in Israel. At 302 km long, it is the second longest highway in Israel, after Highway 90. The highway runs from Kfar Saba in the center of Israel to the Arabah in the south, serving as a main connection between central Israel and Be'er Sheva.
Highway 3 is a highway in Israel. It begins at Highway 4 on the outskirts of Ashkelon, running east-northeast, passing through Kiryat Malakhi and Latrun, and ending just short of Modi'in.
Highway 7 is a highway in the South District of Israel from Ashdod to Yesodot. It connects the Port of Ashdod with the Trans-Israel Highway.
Highway 10 is a road in the South District of Israel. It is one of the longest routes in Israel, extending for nearly the entire border of Israel with Egypt from the Gaza Strip in the north to Sayarim junction in the south. Under a military security advisory, its entire 113-mile length is almost permanently off-limits to civilian traffic.
Highway 13 is an expressway in southern Israel. It is 12 km long. It begins in the north at Tzihor junction with Highway 40 and ends in the south at Menuha junction with Highway 90. Thus, it connects between Highway 40, which runs north to Mizpe Ramon and Beersheba via the central Negev, and Highway 90, which traverses the Arava region on Israel's eastern border.
Highway 25 is a rural highway in southern Israel. It begins northwest of Nahal Oz at the border with the Gaza Strip, and it passes through Netivot, Beersheba and Dimona. It continues southeast toward Arava Junction, where it meets Highway 90. Its length is estimated by the Israeli Department of Transportation as 172 km and 780 meters.
Highway 34 is a highway in the South District of Israel that begins at Yad Mordechai in the north, passes through Sderot, and ends in the south at Netivot. Its length is 19.75 km.
Highway 41 is an arterial road in south-central Israel. It connects Highway 4 and Highway 7 to the Port of Ashdod. The designation "41" also applied to the continuation of the road eastward to Gedera until that section of the road was upgraded and renamed "7".
Highway 92 is a north-south highway in northeastern Israel. It follows the eastern edge of the Kinneret from Ma'agan junction in the south at Highway 98 to Yehudiya junction in the north at Highway 87. It is 24 km long.
Highway 42 is a north-south highway in central Israel. It leads from just south of Ashdod Interchange in the south to Gan Rave interchange in the north. The road is 19 km (12 mi) long.
Highway 46 is a short highway in central Israel. The road, just 4 km long, was created in order to bypass the portion of Highway 40 that crosses the aviation industrial zone near Ben Gurion International Airport, a section of road that suffers from heavy traffic.
Highway 80 is a north-south highway in southern Israel, east of Beersheba. It connects Ar'arat an-Naqab in the south to Metzadot Yehuda in the north. It is 34 km long.
Route 171 is a regional east-west road in southern Israel. It is the only east-west road in the Negev Mountains. It is 33 km long. It goes from Mount Harif junction on Highway 10 adjacent to Israel's border with Egypt to HaRuhot junction with Highway 40 about 5 km north of Mitzpe Ramon. The road passes mostly along the northern edge of Makhtesh Ramon and along the flowing path of Nahal Nitzana. In its eastern portion, it crosses HaRuhot Plain and passes by the Mitzpe Ramon Airport.
Route 999 is an east–west regional route in the northern Golan Heights, which Israel captured from Syria in the Six-Day War in 1967. Its access is restricted to Israeli army vehicles for almost its entire length. It begins from Si'on adjacent to the community Snir and the village Ghajar, where it splits north from Highway 99. About 2 km after this junction stands an IDF checkpoint. After the checkpoint, the road moves in a northeast direction and climbs steeply on Shebaa farms in parallel with the international border between Golan Heights and Lebanon. The road passes near the Shebaa farms while on its steep course in the Mount Hermon nature reserve. For the entire length of the road, IDF installations are standing, and it ends its length of 29 km with another IDF checkpoint near the lower cable car of Mount Hermon, where it meets Highway 98.
Route 899 is an east-west regional highway in the Upper Galilee in northern Israel. For almost its entire length of 63 km, it proceeds parallel to the nearby border between Israel and Lebanon. In Israel, Route 899 is commonly known as the "northern route".
Route 888 is a north-south regional highway in northern Israel. It begins at Beit Tzida junction with Highway 87 and ends at Beit HaMekhes junction with Highway 91.
Highway 45 is the official designation of a 3.3 km stretch of road forming a continuous connection between Route 443 from the Tel Aviv Metropolitan Area and Highway 50 to central Jerusalem and a 1.4 km spur serving the Atarot Industrial Park.
