Highway 5 or the Trans-Samaria Highway, is one of Israel's main highways, connecting the Mediterranean coast immediately north of Tel Aviv with the central Sharon plain and eastwards to Ariel and other Israeli settlements in the northern West Bank.
Highway 22, also known as the Bay Highway, is a suburban freeway in the Haifa metropolitan area connecting downtown Haifa with the city's northern exit to the Krayot. From there it continues northwards as a bypass of the Krayot, providing an alternative route to Highway 4.
Highway 3 is a highway in Israel. It begins at Highway 4 on the outskirts of Ashkelon, running east-northeast, passing through Kiryat Malakhi and Latrun, and ending just short of Modi'in.
Highway 7 is a highway in the South District of Israel from Ashdod to Yad Binyamin. It connects the Port of Ashdod with the Trans-Israel Highway.
Highway 12 is a single carriageway road in the South District of Israel. It surrounds the mountains of Eilat from the north and west, and it connects Eilat to Highway 10 and Highway 40, which lead toward central Israel. Highway 10 continues north toward the Gaza Strip, whereas Highway 40 proceeds to Beersheba via Mizpe Ramon.
Highway 13 is an expressway in southern Israel. It is 12 km long. It begins in the north at Tzihor junction with Highway 40 and ends in the south at Menuha junction with Highway 90. Thus, it connects between Highway 40, which runs north to Mizpe Ramon and Beersheba via the central Negev, and Highway 90, which traverses the Arava region on Israel's eastern border.
Highway 34 is a highway in the South District of Israel that begins at Yad Mordechai in the north, passes through Sderot, and ends in the south at Netivot. Its length is 19.75 km.
Highway 38 is an arterial road in the low plains of Judea in Israel. It serves as the main access route to Beit Shemesh and as a main north–south route in the region. Along the route are many nature preserves and archeological sites.
Highway 41 is an arterial road in south-central Israel. It connects Highway 4 and Highway 7 to the Port of Ashdod. The designation "41" also applied to the continuation of the road eastward to Gedera until that section of the road was upgraded and renamed "7".
Route 293 is a rural road that connects Highway 40 to Netivot and to Route 34 and Highway 25. Many Kibbutzim and Moshavim are along its path.
Highway 98 is the primary north-south highway on the Israeli side of the Golan Heights. It is shaped like an archer's bow, and it runs parallel to the ceasefire line with Syria. The route runs from Tzemah junction south of the Kinneret, first through the Yarmuk valley, then it rises up a steep slope into the Golan Heights and crosses it until it reaches the lowest cable-car station on Mount Hermon. There it meets Route 999. Highway 98 is steep compared to the other highways in Israel, rising from 210 meters below sea level at the Kinneret to 1600 meters above sea level on the Hermon.
Highway 92 is a north-south highway in northeastern Israel. It follows the eastern edge of the Kinneret from Ma'agan junction in the south at Highway 98 to Yehudiya junction in the north at Highway 87. It is 24 km long.
Highway 91 is an east-west highway in northern Israel and the Golan Heights. It extends through the Jordan Rift Valley and the central Golan Heights. It begins in the west at Mahanayim junction with Highway 90, and it ends in the east at Zivan junction near the Israeli settlement Ein Zivan, where it meets Highway 98. The road is 28 km long.
Highway 42 is a north-south highway in central Israel. It leads from just south of Ashdod Interchange in the south to Gan Rave interchange in the north. The road is 19 km (12 mi) long.
Highway 46 is a short highway in central Israel. The road, just 4 km long, was created to bypass the portion of Highway 40 that crosses the aviation industrial zone near Ben Gurion International Airport, a section of road that suffers from heavy traffic.
Highway 87 is a 35 km long east-west highway in northern Israel and the Israeli-occupied Golan Heights. It extends from the northern shores of Lake Kinneret through the central Golan Heights. It begins in the west at Kfar Nahum/Capernaum and ends in the east at Bashan Junction.
Highway 9 is an east-west limited-access expressway in Israel that opened to traffic on July 24, 2014.
Highway 80 is a north-south highway in southern Israel, east of Beersheba. It connects Ar'arat an-Naqab in the south to Metzadot Yehuda in the north. It is 34 km long.
Highway 66 is a north–south highway in the Jezreel Valley in northern Israel.
Highway 45 is the official designation of a 3.3 km stretch of road forming a continuous connection between Route 443 from the Tel Aviv Metropolitan Area and Highway 50 to central Jerusalem and a 1.4 km spur serving the Atarot Industrial Park.
