List of antiviral drugs

Antiviral drugs are different from antibiotics. Flu antiviral drugs are different from antiviral drugs used to treat other infectious diseases such as COVID-19. Antiviral drugs prescribed to treat COVID-19 are not approved or authorized to treat flu. ^[1]

List of Antiviral Drugs

Antiviral	Use	Manufacturer	Component	Type	Year approved
Abacavir	HIV	ViiV Healthcare		Nucleoside analogue reverse transcriptase inhibitor (NRTI)	1998
Acyclovir (Aciclovir)	Herpes Simplex, chickenpox, [2] varicella zoster virus	GSK		guanosine analogue RTI	1981
Adefovir	Hepatitis B [3]	Gilead Sciences		RTI	2002 (FDA), 2003 (EU)
Amantadine	Influenza			Influenza A virus M2 proton channel antagonist	1966
Ampligen	Avian Influenza			Immunomodulatory double-stranded RNA	2016 (Argentina)
Amprenavir (Agenerase)	HIV			Protease inhibitor (PI)	1999 (FDA)
Umifenovir (Arbidol)	Influenza			Hemagglutinin inhibitor
Atazanavir	HIV			PI	2015 (FDA)
Atripla (Efavirenz/emtricitabine/tenofovir)	HIV			Efavirenz: Non-nucleoside RTI (NNRTI) Emtricitabine: NRTI Tenofovir disoproxil: NRTI	1998
Baloxavir marboxil (Xofluza) [4]	Influenza A/B			Cap snatching endonuclease inhibitor	2018
Biktarvy (Bictegravir/emtricitabine/tenofovir alafenamide)	HIV	Gilead Sciences		Bictegravir: INSTI Emtricitabine: NRTI Tenofovir alafenamide: NRTI	2018
Boceprevir	Hepatitis C genotype 1 [5]	Schering-Plough, then Merck Group		Protease inhibitor	FDA approved 2011 Withdrawn 2015
Bulevirtide	Hepatitis D/B			Sodium/bile acid cotransporter inactivator	2020 (EU)
Cidofovir	AIDS			Viral DNA Polymerase inhibitor	1996 (FDA)
Cobicistat (Tybost) [6]	HIV			human CYP3A protein inhibitor
Combivir (Lamivudine/Zidovudine)	HIV			Lamivudine: cytidine analogue RTI Zidovudine: thymidine analogue RTI	1997 (FDA)
Daclatasvir (Daklinza)	Hepatitis C			NS5A inhibitor
Darunavir	HIV		antiretroviral	HIV PI
Delavirdine	HIV		antiretroviral	NNRTI
Descovy (Emtricitabine/tenofovir alafenamide)	Hepatitis B			Emtricitabine: NRTI Tenofovir alafenamide: NRTI
Didanosine	HIV			Adenosine analogue RTI	1991 (FDA)
Docosanol	Herpes Simplex			Entry inhibitor	2000 (FDA)
Dolutegravir	HIV			Integrase inhibitor
Doravirine (Pifeltro) [7]	HIV	Merck & Co		NNRTI	2018 (FDA)
Edoxudine	Herpes Simplex			Thymidine analogue inhibitor
Efavirenz	HIV	Mylan		NNRTI	1998
Elvitegravir	HIV	Gilead Sciences		Integrase inhibitor	2012 (Fixed-dose combo Stribild) 2014 (single pill) 2015 (Genvoya)
Emtricitabine	HIV	Gilead Sciences		NRTI	2003
Enfuvirtide	HIV			Entry inhibitor	2003
Ensitrelvir	COVID-19	Shionogi		3C-like protease inhibitor
Entecavir	HIV			NRTI	2005
Etravirine (Intelence) [8]	HIV			NNRTI	2008
Famciclovir	Herpes Zoster			Guanosine analogue	1994
Fomivirsen	AIDS		Anti-sense oligonucleotide	Anti-sense	FDA-licensed in 1998 Withdrawn in EU (2002), US (2006)
Fosamprenavir	HIV	ViiV Healthcare		Amprenavir pro-drug	2003 (FDA), 2004 (EMA)
Foscarnet	Herpes			Pyrophosphate analogue DNA polymerase inhibitor	1991
Ganciclovir (Cytovene) [9]	Cytomegalovirus (CMV) [10]			Competitive nucleoside analogue dGTP inhibitor	1988
Ibacitabine	Herpes labialis
Ibalizumab (Trogarzo) [11]	HIV			Entry inhibitor	2018
Idoxuridine	Herpes			dU analogue inhibitor	1962
Imiquimod	Genital wart, Basal cell carcinoma, Actinic keratosis			Opioid growth factor receptor (OGFr) agonist	1997
Inosine pranobex	Herpes Simplex			Thymus hormone immunostimulant
Indinavir	HIV			PI	1996
Lamivudine	HIV			cytidine analogue RTI
Letermovir (Prevymis) [12]	Cytomegalovirus (CMV)
Lopinavir	HIV
Loviride	HIV
Maraviroc	HIV			entry inhibitor
Methisazone	Smallpox
Molnupiravir	COVID-19	Merck & Co.		viral RNA polymerase inhibitor
Moroxydine	Influenza
Nelfinavir	HIV
Nirmatrelvir/ritonavir (Paxlovid)	COVID-19	Pfizer		3C-like protease inhibitor (Nirmatrelvir) / inhibition of metabolism of nirmatrelvir (ritonavir)
Nevirapine	HIV			non-nucleoside reverse transcriptase inhibitor
Nitazoxanide	Broad-spectrum antiviral		thiazolide
Norvir	HIV
Oseltamivir (Tamiflu) [13]	Influenza			neuraminidase inhibitor
Peramivir (Rapivab) [14]	Influenza
Penciclovir	Herpes
Pleconaril	Picornavirus	Schering-Plough
Podophyllotoxin	Genital wart
Raltegravir	HIV			Integrase inhibitor
Raphamin
Remdesivir	COVID-19			viral RNA polymerase inhibitor
Ribavirin	Hepatitis C [15]			nucleoside analogue reverse transcriptase inhibitor
Rilpivirine (Edurant) [16]	HIV
Rimantadine	Influenza A			M2 proton channel antagonist
Ritonavir	HIV			HIV-1 protease inhibitor
Saquinavir	HIV
Simeprevir (Olysio)	Hepatitis C
Sofosbuvir	Hepatitis C [17]			nucleoside analogue reverse transcriptase inhibitor
Stavudine	HIV
Taribavirin (Viramidine)	Hepatitis Syndromes in which Ribavirin is active [18]
Telaprevir	Hepatitis C
Telbivudine (Tyzeka)	Hepatitis B
Tenofovir alafenamide	Hepatitis B
Tenofovir disoproxil	Hepatitis B, HIV [19]
Tipranavir	HIV
Trifluridine	Eyes related Herpes
Trizivir	HIV
Tromantadine	Herpes Simplex
Truvada	HIV
Umifenovir	Influenza
Valaciclovir (Valtrex) [20]	Herpes Simplex/Zoster
Valganciclovir (Valcyte) [21]	Cytomegalovirus (CMV)
Vicriviroc	HIV-1	Schering-Plough		pyrimidine CCR5 entry inhibitor
Vidarabine	Herpes Simplex, Varicella Zoster
Zalcitabine	HIV
Zanamivir (Relenza) [22]	Influenza A, Influenza B
Zidovudine	HIV [23]		Antiretroviral

References

1. "What You Should Know about Flu Antiviral Drugs". 15 December 2022.
2. "Acyclovir". The American Society of Health-System Pharmacists. Archived from the original on 2015-01-05. Retrieved Jan 1, 2015.
3. Marcellin P, Chang TT, Lim SG, Tong MJ, Sievert W, Shiffman ML, et al. (February 2003). "Adefovir dipivoxil for the treatment of hepatitis B e antigen-positive chronic hepatitis B". The New England Journal of Medicine. 348 (9): 808–16. doi: 10.1056/NEJMoa020681 . PMID   12606735.
4. "Xofluza- baloxavir marboxil tablet, film coated". DailyMed. 28 October 2019. Retrieved 21 September 2020.
5. Degertekin B, Lok AS (2008). "Update on viral hepatitis: 2007". Curr. Opin. Gastroenterol. 24 (3): 306–11. doi:10.1097/MOG.0b013e3282f70285. PMID   18408458. S2CID   43762307.
6. "Tybost- cobicistat tablet, film coated". DailyMed. 27 August 2020. Retrieved 21 September 2020.
7. "Pifeltro- doravirine tablet, film coated". DailyMed. 10 October 2019. Retrieved 21 September 2020.
8. "Intelence- etravirine tablet". DailyMed. 9 June 2020. Retrieved 21 September 2020.
9. "Cytovene IV- ganciclovir sodium injection, powder, lyophilized, for solution". DailyMed. 19 June 2020. Retrieved 21 September 2020.
10. Rossi S, editor. Australian Medicines Handbook 2006. Adelaide: Australian Medicines Handbook; 2006. ISBN   0-9757919-2-3
11. "Trogarzo- ibalizumab injection, solution". DailyMed. 8 April 2020. Retrieved 21 September 2020.
12. "Prevymis- letermovir tablet, film coated PREVYMIS- letermovir injection, solution". DailyMed. 23 March 2020. Retrieved 21 September 2020.
13. "Tamiflu- oseltamivir phosphate capsule TAMIFLU- oseltamivir phosphate powder, for suspension". DailyMed. Retrieved 21 September 2020.
14. "Rapivab- peramivir solution". DailyMed. 3 August 2020. Retrieved 21 September 2020.
15. "Rebetol, Ribasphere (ribavirin) dosing, indications, interactions, adverse effects, and more". Medscape Reference. WebMD. Archived from the original on 28 February 2014. Retrieved 23 February 2014.
16. "Edurant- rilpivirine hydrochloride tablet, film coated". DailyMed. 8 June 2020. Retrieved 21 September 2020.
17. Berden FA, Kievit W, Baak LC, Bakker CM, Beuers U, Boucher CA, Brouwer JT, Burger DM, van Erpecum KJ, van Hoek B, Hoepelman AI, Honkoop P, Kerbert-Dreteler MJ, de Knegt RJ, Koek GH, van Nieuwkerk CM, van Soest H, Tan AC, Vrolijk JM, Drenth JP (October 2014). "Dutch guidance for the treatment of chronic hepatitis C virus infection in a new therapeutic era". The Netherlands Journal of Medicine. 72 (8): 388–400. PMID   25387551.
18. Gish RG (2006). "Treating HCV with ribavirin analogues and ribavirin-like molecules". The Journal of Antimicrobial Chemotherapy. 57 (1): 8–13. doi:10.1093/jac/dki405. PMID   16293677.
19. "Tenofovir Disoproxil Fumarate". The American Society of Health-System Pharmacists. Archived from the original on 30 November 2016. Retrieved 29 November 2016.
20. "Valtrex- valacyclovir hydrochloride tablet, film coated". DailyMed. 10 December 2019. Retrieved 21 September 2020.
21. "Valcyte- valganciclovir tablet, film coated VALCYTE- valganciclovir hydrochloride powder, for solution". DailyMed. 9 August 2018. Retrieved 3 September 2022.
22. "Relenza- zanamivir powder". DailyMed. 21 June 2018. Retrieved 21 September 2020.
23. "Zidovudine". PubChem Public Chemical Database. NCBI. Archived from the original on October 25, 2012. Retrieved April 10, 2011.