Entecavir

Last updated

Entecavir
Entecavir structure.svg
Entecavir ball-and-stick model.png
Clinical data
Pronunciation /ɛnˈtɛkəvɪər/ en-TEK-ə-veer
Trade names Baraclude, others
Other namesETV, BMS-200475-01
AHFS/Drugs.com Monograph
MedlinePlus a605028
License data
Pregnancy
category
Routes of
administration 		By mouth
ATC code
Legal status
Legal status
Pharmacokinetic data
Bioavailability n/a (≥70) [2]
Protein binding 13% (in vitro)
Metabolism negligible/nil
Elimination half-life 128–149 hours
Excretion Kidney 62–73%
Identifiers
  • 2-Amino-9-[(1S,3R,4S)-4-hydroxy-3-(hydroxymethyl)-2-methylidenecyclopentyl]-1H-purin-6-one
CAS Number
PubChem CID
DrugBank
ChemSpider
UNII
KEGG
ChEBI
ChEMBL
CompTox Dashboard (EPA)
ECHA InfoCard 100.111.234 OOjs UI icon edit-ltr-progressive.svg
Chemical and physical data
Formula C12H15N5O3
Molar mass 277.284 g·mol−1
3D model (JSmol)
Melting point 220 °C (428 °F) value applies to entecavir monohydrate and is a minimum value [4]
  • C=C1C(CC(C1CO)O)N2C=NC3=C2N=C(NC3=O)N
  • InChI=1S/C12H15N5O3/c1-5-6(3-18)8(19)2-7(5)17-4-14-9-10(17)15-12(13)16-11(9)20/h4,6-8,18-19H,1-3H2,(H3,13,15,16,20)/t6-,7-,8-/m0/s1 X mark.svgN
  • Key:QDGZDCVAUDNJFG-FXQIFTODSA-N X mark.svgN
 X mark.svgNYes check.svgY  (what is this?)    (verify)

Entecavir, sold under the brand name Baraclude, is an antiviral medication used in the treatment of hepatitis B virus infection. [5] In those with both HIV/AIDS and hepatitis B virus antiretroviral medication should also be used. [5] Entecavir is taken by mouth as a tablet or solution. [5]

Contents

Common side effects include headache, nausea, high blood sugar, and decreased kidney function. [5] Severe side effects include enlargement of the liver, high blood lactate levels, and liver inflammation if the medication is stopped. [5] While there appears to be no harm from use during pregnancy, this use has not been well studied. [1] Entecavir is in the nucleoside reverse transcriptase inhibitors (NRTIs) family of medications. [5] [6] It prevents the hepatitis B virus from multiplying by blocking reverse transcriptase. [5]

Entecavir was approved for medical use in 2005. [5] It is on the World Health Organization's List of Essential Medicines. [7] It is available as a generic medication.

Medical uses

Entecavir is mainly used to treat chronic hepatitis B infection in adults and children two years and older with active viral replication and evidence of active disease with elevations in liver enzymes. [2] It is also used to prevent hepatitis B virus reinfection after liver transplant [8] and to treat HIV patients infected with hepatitis B virus. Entecavir is weakly active against HIV, but is not recommended for use in HIV-HBV co-infected patients without a fully suppressive anti-HIV regimen [9] as it may select for resistance to lamivudine and emtricitabine in HIV. [10]

The efficacy of entecavir has been studied in several randomized, double-blind, multicentre trials. Entecavir by mouth is effective and generally well tolerated treatment. [11]

Pregnancy and breastfeeding

No adequate and well-controlled studies exist in pregnant women. [1]

Side effects

The majority of people who use entecavir have little to no side effects. [12] The most common side effects include headache, fatigue, dizziness, and nausea. [2] Less common effects include trouble sleeping and gastrointestinal symptoms such as sour stomach, diarrhea, and vomiting. [13]

Serious side effects from entecavir include lactic acidosis, liver problems, liver enlargement, and fat in the liver. [2]

Laboratory tests may show an increase in alanine transaminase (ALT), hematuria, glycosuria, and an increase in lipase. [2] Periodic monitoring of hepatic function and hematology are recommended. [2]

Mechanism of action

Entecavir is a nucleoside analog, [14] or more specifically, a deoxyguanosine analogue that belongs to a class of carbocyclic nucleosides and inhibits reverse transcription, DNA replication and transcription in the viral replication process. Other nucleoside and nucleotide analogues include lamivudine, telbivudine, adefovir dipivoxil, and tenofovir.

Entecavir reduces the amount of hepatitis B virus in the blood by reducing its ability to multiply and infect new cells. [15]

Administration

Entecavir is taken by mouth as a tablet or solution. Doses are based on a person's weight. [2] The solution is recommended for children more than 2 years old who weigh up to 30 kg. Entecavir is recommended on an empty stomach at least 2 hours before or after a meal, generally at the same time every day. It is not used in children less than 2 years old. Dose adjustments are also recommended for people with decreased kidney function. [2]

History

Patent information

Bristol-Myers Squibb was the original patent holder for Baraclude, the brand name of entecavir in the US and Canada. The drug patent expiration for Baraclude was in 2015. [27] [28] Entecavir patents were a subject of litigation in the US between Bristol Myers Squibb (the patent owner) and Teva Pharmaceuticals USA (a generic manufacturer). The lawsuit resulted in a relatively rare in the pharmaceutical field patent invalidation for obviousness, which was affirmed in June 2014, by the US Court of Appeals for the Federal Circuit (752 F.32d 967).

In August 2014, Teva Pharmaceuticals USA gained FDA approval for generic equivalents of Baraclude 0.5 mg and 1 mg tablets; [29] Hetero Labs received such approval on 21 August 2015; [30] and Aurobindo Pharma on 26 August 2015. [31]

References

  1. 1 2 3 "Entecavir (Baraclude) Use During Pregnancy". Drugs.com. 3 December 2019. Archived from the original on 7 November 2016. Retrieved 24 January 2021.
  2. 1 2 3 4 5 6 7 8 9 "Baraclude- entecavir tablet, film coated Baraclude- entecavir solution". DailyMed. Archived from the original on 8 November 2016. Retrieved 24 January 2021.
  3. ↑ "Baraclude EPAR". European Medicines Agency. 26 June 2006. Archived from the original on 6 March 2024. Retrieved 5 July 2024.
  4. ↑ O'Neil MJ (2006). "The Merck Index: An Encyclopedia of Chemicals, Drugs, and Biologicals". The Merck Index (14th ed.). p. 613. ISBN   978-0-911910-00-1.
  5. 1 2 3 4 5 6 7 8 "Entecavir". The American Society of Health-System Pharmacists. Archived from the original on 20 December 2016. Retrieved 28 November 2016.
  6. ↑ Shetty K, Wu GY (2009). Chronic Viral Hepatitis: Diagnosis and Therapeutics. Springer Science & Business Media. p. 34. ISBN   9781597455657.
  7. ↑ World Health Organization (2023). The selection and use of essential medicines 2023: web annex A: World Health Organization model list of essential medicines: 23rd list (2023). Geneva: World Health Organization. hdl: 10665/371090 . WHO/MHP/HPS/EML/2023.02.
  8. ↑ Fung J, Cheung C, Chan SC, Yuen MF, Chok KS, Sharr W, et al. (October 2011). "Entecavir monotherapy is effective in suppressing hepatitis B virus after liver transplantation". Gastroenterology. 141 (4): 1212–1219. doi: 10.1053/j.gastro.2011.06.083 . PMID   21762659.
  9. ↑ "Guidelines for the use of antiretroviral agents in HIV-1-infected adults and adolescents" (PDF). Panel on Antiretroviral Guidelines for Adults and Adolescents. Archived from the original (PDF) on 1 November 2016. Retrieved 15 March 2015.
  10. ↑ McMahon MA, Jilek BL, Brennan TP, Shen L, Zhou Y, Wind-Rotolo M, et al. (June 2007). "The HBV drug entecavir - effects on HIV-1 replication and resistance". The New England Journal of Medicine. 356 (25): 2614–2621. doi:10.1056/NEJMoa067710. PMC   3069686 . PMID   17582071.
  11. ↑ Scott LJ, Keating GM (May 2009). "Entecavir: a review of its use in chronic hepatitis B". Drugs. 69 (8): 1003–1033. doi:10.2165/00003495-200969080-00005. PMID   19496629. S2CID   115493805. Archived from the original on 8 October 2011. Retrieved 29 March 2010.
  12. ↑ "Entecavir: Indications, Side Effects, Warnings - Drugs.com". www.drugs.com. Archived from the original on 7 November 2016. Retrieved 10 November 2016.
  13. ↑ "Entecavir Side Effects in Detail - Drugs.com". www.drugs.com. Archived from the original on 10 November 2016. Retrieved 10 November 2016.
  14. ↑ Sims KA, Woodland AM (December 2006). "Entecavir: a new nucleoside analog for the treatment of chronic hepatitis B infection". Pharmacotherapy. 26 (12): 1745–1757. doi: 10.1592/phco.26.12.1745 . PMID   17125436. S2CID   13149070.
  15. ↑ "Entecavir: Indications, Side Effects, Warnings - Drugs.com". www.drugs.com. Archived from the original on 7 November 2016. Retrieved 7 November 2016.
  16. ↑ Slusarchyk, WA, Field AK, Greytok JA, Taunk P, Tooumari AV, et al. (1992). "4-Hydroxy-3-(hydroxymethyl)-2-methylenecyclopentyl purines and pyrimidines, a new class of anti-herpesvirus agents". Antiviral Research. 17: 98. doi:10.1016/0166-3542(92)90200-o.
  17. 1 2 Bisacchi GS, Chao ST, Bachard C, Daris JP, Innaimo SF, Jacobs JA, et al. (1997). "BMS-200475, a novel carbocyclic 29-deoxyguanosine analog with potent and selective antihepatitis B virus activity in vitro". Bioorganic & Medicinal Chemistry Letters. 7 (2): 127–132. doi:10.1016/s0960-894x(96)00594-x.
  18. ↑ Innaimo SF, Seifer M, Bisacchi GS, Standring DN, Zahler R, Colonno RJ (July 1997). "Identification of BMS-200475 as a potent and selective inhibitor of hepatitis B virus". Antimicrobial Agents and Chemotherapy. 41 (7): 1444–1448. doi:10.1128/AAC.41.7.1444. PMC   163937 . PMID   9210663.
  19. ↑ Seifer M, Hamatake RK, Colonno RJ, Standring DN (December 1998). "In vitro inhibition of hepadnavirus polymerases by the triphosphates of BMS-200475 and lobucavir". Antimicrobial Agents and Chemotherapy. 42 (12): 3200–3208. doi:10.1128/AAC.42.12.3200. PMC   106023 . PMID   9835515.
  20. ↑ Yamanaka G, Wilson T, Innaimo S, Bisacchi GS, Egli P, Rinehart JK, et al. (January 1999). "Metabolic studies on BMS-200475, a new antiviral compound active against hepatitis B virus". Antimicrobial Agents and Chemotherapy. 43 (1): 190–193. doi: 10.1128/AAC.43.1.190 . PMC   89048 . PMID   9869593.
  21. ↑ Colonno RJ, Genovesi EV, Medina I, Lamb L, Durham SK, Huang ML, et al. (November 2001). "Long-term entecavir treatment results in sustained antiviral efficacy and prolonged life span in the woodchuck model of chronic hepatitis infection". The Journal of Infectious Diseases. 184 (10): 1236–1245. doi: 10.1086/324003 . PMID   11679911.
  22. ↑ Levine S, Hernandez D, Yamanaka G, Zhang S, Rose R, Weinheimer S, et al. (August 2002). "Efficacies of entecavir against lamivudine-resistant hepatitis B virus replication and recombinant polymerases in vitro". Antimicrobial Agents and Chemotherapy. 46 (8): 2525–2532. doi:10.1128/aac.46.8.2525-2532.2002. PMC   127388 . PMID   12121928.
  23. ↑ Chang TT, Gish RG, de Man R, Gadano A, Sollano J, Chao YC, et al. (March 2006). "A comparison of entecavir and lamivudine for HBeAg-positive chronic hepatitis B". The New England Journal of Medicine. 354 (10): 1001–1010. doi: 10.1056/nejmoa051285 . hdl: 1765/71057 . PMID   16525137.
  24. ↑ Lai CL, Shouval D, Lok AS, Chang TT, Cheinquer H, Goodman Z, et al. (March 2006). "Entecavir versus lamivudine for patients with HBeAg-negative chronic hepatitis B". The New England Journal of Medicine. 354 (10): 1011–1020. doi: 10.1056/NEJMoa051287 . hdl: 10722/45018 . PMID   16525138.
  25. ↑ Sherman M, Yurdaydin C, Sollano J, Silva M, Liaw YF, Cianciara J, et al. (June 2006). "Entecavir for treatment of lamivudine-refractory, HBeAg-positive chronic hepatitis B". Gastroenterology. 130 (7): 2039–2049. doi: 10.1053/j.gastro.2006.04.007 . PMID   16762627.
  26. ↑ "Drug Approval Package: Baraclude (Entecavir) NDA #021797 & 021798". U.S. Food and Drug Administration (FDA). 28 December 2011. Archived from the original on 24 March 2013. Retrieved 24 January 2021.
  27. ↑ "Orange Book: Approved Drug Products with Therapeutic Equivalence Evaluations". U.S. Food and Drug Administration (FDA). Archived from the original on 4 March 2016. Retrieved 29 August 2015.
  28. ↑ "Orange Book: Approved Drug Products with Therapeutic Equivalence Evaluations". U.S. Food and Drug Administration (FDA). Archived from the original on 15 November 2016. Retrieved 14 November 2016.
  29. ↑ "Orange Book: Approved Drug Products with Therapeutic Equivalence Evaluations". U.S. Food and Drug Administration (FDA). Search results from the "OB_Rx" table for query on "202122.". Archived from the original on 22 December 2015. Retrieved 29 August 2015.
  30. ↑ "Orange Book: Approved Drug Products with Therapeutic Equivalence Evaluations". U.S. Food and Drug Administration (FDA). Search results from the "OB_Rx" table for query on "205740.". Archived from the original on 4 March 2016. Retrieved 29 August 2015.
  31. ↑ "Orange Book: Approved Drug Products with Therapeutic Equivalence Evaluations". U.S. Food and Drug Administration (FDA). Search results from the "OB_Rx" table for query on "206217.". Archived from the original on 4 March 2016. Retrieved 29 August 2015.
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