Loviride

Loviride

Clinical data
Other names	R089439; loveride[ citation needed ]
ATC code	None
Identifiers
IUPAC name 2-[(2-Acetyl-5-methylphenyl)amino]-2-(2,6-dichlorophenyl)acetamide
CAS Number	147362-57-0  N
PubChem CID	3963
ChemSpider	3826  Y
UNII	3S1R1LZ09H
KEGG	D04786  Y
ChEMBL	ChEMBL37624  Y
CompTox Dashboard (EPA)	DTXSID60869958
Chemical and physical data
Formula	C17H16Cl2N2O2
Molar mass	351.23 g·mol−1
3D model (JSmol)	Interactive image
SMILES Clc1cccc(Cl)c1C(Nc2cc(ccc2C(=O)C)C)C(=O)N
InChI InChI=1S/C17H16Cl2N2O2/c1-9-6-7-11(10(2)22)14(8-9)21-16(17(20)23)15-12(18)4-3-5-13(15)19/h3-8,16,21H,1-2H3,(H2,20,23) Y Key:CJPLEFFCVDQQFZ-UHFFFAOYSA-N Y
NY  (what is this?)    (verify)

Loviride is an experimental antiviral drug manufactured by Janssen (now part of Janssen-Cilag) that is active against HIV. Loviride is a non-nucleoside reverse transcriptase inhibitor (NNRTI) that entered phase III clinical trials in the late 1990s, but failed to gain marketing approval because of poor potency. ^[1] It is of clinical significance only in those patients who were enrolled in clinical trials to evaluate loviride (e.g., CAESAR ^[2] and AVANTI ^[3] ), because in those trials loviride was often given alone and with no companion drug, leading to a high probability of developing reverse transcriptase mutations such as K103N which result in cross-class resistance to the NNRTIs efavirenz and nevirapine.

References

1. "Loviride". aidsmap.com. Archived from the original on 2007-09-27.
2. Kroon ED, Wit FW, et al. (CAESAR Coordinating Committee) (1997). "Randomised trial of addition of lamivudine or lamivudine plus loviride to zidovudine-containing regimens for patients with HIV-1 infection: The CAESAR trial". The Lancet. 349 (9063): 1413–1421. doi:10.1016/S0140-6736(97)04441-3. S2CID   20008082.
3. Gatell J, Lange J, Gartland M (1999). "AVANTI 1: randomized, double-blind trial to evaluate the efficacy and safety of zidovudine plus lamivudine versus zidovudine plus lamivudine plus loviride in HIV-infected antiretroviral-naive patients. AVANTI Study Group". Antiviral Therapy. 4 (2): 79–86. doi: 10.1177/135965359900400204 . PMID   10682152. S2CID   22443598.