|Palace of the Holy Office|
Palazzo del Santo Uffizio
|Former names||Palazzo Pucci|
|Coordinates||41°54′4″N12°27′22″E / 41.90111°N 12.45611°E Coordinates: 41°54′4″N12°27′22″E / 41.90111°N 12.45611°E|
|Current tenants||Congregation for the Doctrine of the Faith|
|Construction started||c. 1514|
|Renovated||1566–67 and 1921–25|
|Client||Cardinal Lorenzo Pucci|
|Design and construction|
|Architect(s)|| Pirro Ligorio |
Giovanni Sallustio Peruzzi
The Palace of the Holy Office (Italian : Palazzo del Santo Uffizio) is a building in Rome which is an extraterritorial property of Vatican City. It houses the Holy Office of the Roman Catholic Church.
The palace is situated south of Saint Peter's Basilica near the Petrine Gate to Vatican City. The building lies outside the confines of Vatican City at the south-eastern corner of the city-state. It is one of the properties of the Holy See in Italy regulated by the 1929 Lateran Treaty signed with the Kingdom of Italy. As such, it has extraterritorial status.
The palace was first built after 1514 for Cardinal Lorenzo Pucci, and it was called Palazzo Pucci. Its façade was rebuilt in 1524–1525 by the architects Giuliano Leni, Pietro Roselli and even Michelangelo. When Pucci died in 1531, the building was still not fully completed. 
In 1566–1567, the palace was purchased by Pope Pius V for 9000 scudi, and it was converted into the seat of the Holy Office. Renovation works were undertaken by Pirro Ligorio and Giovanni Sallustio Peruzzi. A complete renovation of the building was made by Pietro Guidi between 1921 and 1925. 
It is where Cardinal Joseph Ratzinger formerly worked as Prefect of the Congregation. 
The Holy See, also called the See of Rome, Petrine See or Apostolic See, is the jurisdiction of the Pope in his role as the bishop of Rome. It includes the apostolic episcopal see of the Diocese of Rome, which has ecclesiastical jurisdiction over the Catholic Church and sovereignity over the city-state known as the Vatican City.
Vatican City, officially Vatican City State, is an independent city-state, microstate and enclave within Rome, Italy. It became independent from Italy in 1929 with the Lateran Treaty, and it is a distinct territory under "full ownership, exclusive dominion, and sovereign authority and jurisdiction" of the Holy See, itself a sovereign entity of international law, which maintains the city state's temporal, diplomatic, and spiritual independence. With an area of 49 hectares and a 2019 population of about 453, it is the smallest state in the world both by area and population. As governed by the Holy See, Vatican City State is an ecclesiastical or sacerdotal-monarchical state ruled by the Pope who is the bishop of Rome and head of the Catholic Church. The highest state functionaries are all Catholic clergy of various origins. After the Avignon Papacy (1309–1377) the popes have mainly resided at the Apostolic Palace within what is now Vatican City, although at times residing instead in the Quirinal Palace in Rome or elsewhere. The Vatican is also a metonym for the Holy See.
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