Carrimycin

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Carrimycin
Carrimycin.svg
Carrimycin mixture: R = H, acetyl, or propionyl
Clinical data
Trade names Bite [1]
Other namesIsovalerylspiramycin
Legal status
Legal status
  • In general: ℞ (Prescription only)
Identifiers
DrugBank
UNII

Carrimycin is a macrolide antibiotic. It was approved by the National Medical Products Administration of China in 2019. [1] It is approved for the treatment of acute tracheal bronchitis caused by Haemophilus influenzae , Streptococcus pneumoniae , and for the treatment of acute sinusitis caused by S. pneumoniae, H. influenzae, Streptococcus pyogenes , Moraxella catarrhalis , and Staphylococcus . [2] Carrimycin is mainly used for the treatment of upper respiratory tract infections. [1]

Carrimycin is a mixture of related chemical compounds, carrimycin I through III, which are each ester derivatives of spiramycin. [3]

Carrimycin has also been investigated for the treatment of COVID-19. [2] [4]

Related Research Articles

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Streptococcus is a genus of gram-positive or spherical bacteria that belongs to the family Streptococcaceae, within the order Lactobacillales, in the phylum Bacillota. Cell division in streptococci occurs along a single axis, thus when growing they tend to form pairs or chains, which may appear bent or twisted. This differs from staphylococci, which divide along multiple axes, thereby generating irregular, grape-like clusters of cells. Most streptococci are oxidase-negative and catalase-negative, and many are facultative anaerobes.

<span class="mw-page-title-main">Pneumonia</span> Inflammation of the alveoli of the lungs

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<i>Streptococcus pneumoniae</i> Species of bacterium

Streptococcus pneumoniae, or pneumococcus, is a Gram-positive, spherical bacteria, alpha-hemolytic member of the genus Streptococcus. S. pneumoniae cells are usually found in pairs (diplococci) and do not form spores and are non motile. As a significant human pathogenic bacterium S. pneumoniae was recognized as a major cause of pneumonia in the late 19th century, and is the subject of many humoral immunity studies.

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<span class="mw-page-title-main">Upper respiratory tract infection</span> Infection of the nose, sinuses, pharynx, larynx or trachea

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<i>Chlamydia pneumoniae</i> Species of bacterium

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<span class="mw-page-title-main">Acute exacerbation of chronic obstructive pulmonary disease</span> Medical condition

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References

  1. 1 2 3 "Class I drug Carrimycin approved by National Medical Products Administration of China". Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences & Peking Union Medical College. July 5, 2019.
  2. 1 2 Yan H, Sun J, Wang K, Wang H, Wu S, Bao L, et al. (September 2021). "Repurposing carrimycin as an antiviral agent against human coronaviruses, including the currently pandemic SARS-CoV-2". Acta Pharmaceutica Sinica. B. 11 (9): 2850–2858. doi:10.1016/j.apsb.2021.02.024. PMC   7946546 . PMID   33723501.
  3. Yu LC, Dang DD, Zhuang S, Chen S, Zhuang Z, Rosenblum JS (April 2023). "Carrimycin, a first in-class anti-cancer agent, targets selenoprotein H to induce nucleolar oxidative stress and inhibit ribosome biogenesis". Cancer Pathogenesis and Therapy. 1 (2): 111–115. doi:10.1016/j.cpt.2022.12.005. PMC   10518895 . PMID   37750087.
  4. Al-Horani RA, Kar S, Aliter KF (July 2020). "Potential Anti-COVID-19 Therapeutics that Block the Early Stage of the Viral Life Cycle: Structures, Mechanisms, and Clinical Trials". International Journal of Molecular Sciences. 21 (15): 5224. doi: 10.3390/ijms21155224 . PMC   7432953 . PMID   32718020.