Nafithromycin

Nafithromycin
Clinical data
Other names	WCK-4873
ATC code	None;
Identifiers
	IUPAC name (1S,2R,5R,7R,8R,9R,11R,13R,14S,15R)-8-[(2S,3R,4S,6R)-4-(dimethylamino)-3-hydroxy-6-methyloxan-2-yl]oxy-2-ethyl-9-methoxy-1,5,7,9,11,13-hexamethyl-4,6,12,16-tetraoxo-N'-[(1S)-1-(5-pyridin-2-yl-1,3,4-thiadiazol-2-yl)ethoxy]-3,17-dioxabicyclo[12.3.0]heptadecane-15-carboximidamide;
CAS Number	1691240-78-4 ;
PubChem CID	117587595 ;
UNII	75F74Y2R70 ;
Chemical and physical data
Formula	C42H62N6O11S
Molar mass	859.05 g·mol−1
3D model (JSmol)	Interactive image ;
	SMILES CC[C@@H]1[C@@]2([C@@H]([C@H](C(=O)[C@@H](C[C@@]([C@@H]([C@H](C(=O)[C@H](C(=O)O1)C)C)O[C@H]3[C@@H]([C@H](C[C@H](O3)C)N(C)C)O)(C)OC)C)C)[C@@H](C(=O)O2)/C(=N/O[C@@H](C)C4=NN=C(S4)C5=CC=CC=N5)/N)C;
	InChI InChI=1S/C42H62N6O11S/c1-13-28-42(9)30(29(39(53)58-42)35(43)47-59-25(7)36-45-46-37(60-36)26-16-14-15-17-44-26)22(4)31(49)20(2)19-41(8,54-12)34(23(5)32(50)24(6)38(52)56-28)57-40-33(51)27(48(10)11)18-21(3)55-40/h14-17,20-25,27-30,33-34,40,51H,13,18-19H2,1-12H3,(H2,43,47)/t20-,21-,22-,23+,24-,25+,27+,28-,29-,30+,33-,34-,40+,41-,42-/m1/s1; Key:RLFCSBSRGRJFRO-QAOQTAGDSA-N;

Last updated June 15, 2025

Nafithromycin is an experimental antibiotic medication for the treatment of pneumonia.^[1]^[2]

References

↑ Iwanowski P, Bhatia A, Gupta M, Patel A, Chavan R, Yeole R, et al. (September 2019). "Safety, tolerability and pharmacokinetics of oral nafithromycin (WCK4873) after single or multiple doses and effects of food on single-dose bioavailability in healthy adult subjects". Antimicrobial Agents and Chemotherapy. 63 (12). doi:10.1128/AAC.01253-19. PMC 6879255 . PMID 31591119.
↑ Sellarès-Nadal J, Burgos J, Falcó V, Almirante B (2020). "Investigational and Experimental Drugs for Community-Acquired Pneumonia: the Current Evidence". Journal of Experimental Pharmacology. 12: 529–538. doi: 10.2147/JEP.S259286 . PMC 7682597 . PMID 33239925.

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[1] Iwanowski P, Bhatia A, Gupta M, Patel A, Chavan R, Yeole R, et al. (September 2019). "Safety, tolerability and pharmacokinetics of oral nafithromycin (WCK4873) after single or multiple doses and effects of food on single-dose bioavailability in healthy adult subjects". Antimicrobial Agents and Chemotherapy. 63 (12). doi:10.1128/AAC.01253-19. PMC 6879255 . PMID 31591119.

[2] Sellarès-Nadal J, Burgos J, Falcó V, Almirante B (2020). "Investigational and Experimental Drugs for Community-Acquired Pneumonia: the Current Evidence". Journal of Experimental Pharmacology. 12: 529–538. doi: 10.2147/JEP.S259286 . PMC 7682597 . PMID 33239925.

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