Chelidonium majus | |
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Scientific classification | |
Kingdom: | Plantae |
Clade: | Tracheophytes |
Clade: | Angiosperms |
Clade: | Eudicots |
Order: | Ranunculales |
Family: | Papaveraceae |
Tribe: | Chelidonieae |
Genus: | Chelidonium |
Species: | C. majus |
Binomial name | |
Chelidonium majus | |
Synonyms [1] [2] | |
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Chelidonium majus, the greater celandine, is a perennial herbaceous flowering plant in the poppy family Papaveraceae. One of two species in the genus Chelidonium , it is native to Europe and western Asia and introduced widely in North America.
The plant known as lesser celandine ( Ficaria verna ) is not closely related, as it belongs to the buttercup family Ranunculaceae.
Greater celandine is a perennial herbaceous plant with an erect habit, and reaches 30–120 cm (12–47 in) high. The blue-green [3] leaves are pinnate with lobed and wavy margins, up to 30 cm (12 in) long. When injured, the plant exudes a yellow to orange latex. [3] [4] : 96
The flowers consist of four yellow petals, each about 18 mm (0.71 in) long, with two sepals. A double-flowered variety occurs naturally. The flowers appear from late spring to summer, May to September (in the UK), [3] in umbelliform cymes of about four flowers.
The seeds are small and black, borne in a long, cylindrical capsule. Each has an elaiosome, which attracts ants to disperse the seeds (myrmecochory). [3]
Chelidonium majus is one of the many species described by the father of taxonomy, Carl Linnaeus, in volume one of his Species Plantarum in 1753. [5]
According to the Oxford English Dictionary, the name celandine comes from Late Latin celidonia, from earlier Latin chelidonia or chelidonium, and ultimately from Ancient Greek χελιδόνιον, from χελιδών (chelidṓn) "swallow", hence the common name "swallowwort". Ancient writers said that the flower bloomed when the swallows returned and faded when they left. [6] [7] Chelidonium majus has also been called great celandine, [8] , nipplewort, [8] tetterwort, [9] or simply "celandine". [8] The common name tetterwort also refers to Sanguinaria canadensis . [10]
Chelidonium majus is native in most regions of Europe. It is also found in North Africa in Macaronesia, Algeria and Morocco. In Western Asia it is found in the Caucasus, Armenia, Azerbaijan, Georgia, Kazakhstan, Mongolia, Siberia, Iran and Turkey. [8] Its habitats include rocky slopes, woodlands, waste areas, and roadsides. [11]
It is considered an aggressive invasive plant in parts of North America, and an invasive plant in other areas. In Wisconsin, for example, it is a restricted plant. [12] [13] Control is obtained mainly via pulling or spraying the plant before seed dispersal.
The whole plant is toxic in moderate doses as it contains a range of isoquinoline alkaloids; use in herbal medicine requires the correct dose. [14] The main alkaloid present in the herb and root is coptisine. Other alkaloids present include methyl 2'-(7,8-dihydrosanguinarine-8-yl)acetate, allocryptopine, [15] stylopine, protopine, cryptopine, hemochelidonine, homochelidonine, norchelidonine, berberine, chelidonine, sanguinarine, chelerythrine, [16] and 8-hydroxydihydrosanguinarine. [17] Sanguinarine is particularly toxic with an LD50 of 18 mg per kg body weight (IP in rats). [18] Caffeic acid derivatives, such as caffeoylmalic acid, are also present. [19]
The characteristic latex also contains proteolytic enzymes and the phytocystatin chelidostatin, a cysteine protease inhibitor. [20] It is a traditional folk remedy against warts in France [21] and the UK. It is used in the preparation of a range of off-the-shelf treatments for warts and skin conditions. [22]
Chelidonium is used to make Ukrain, a drug that has been promoted for, but is not known to be effective for, the treatment of cancer and viral infections. [23] [24]
The fresh herb is no longer used officially. No dose-finding studies exist and the reported clinical studies are characterised by a considerable heterogeneity. [25]
Except for homeopathic medicines, the drug is no longer used in most English-speaking countries. In Germany and Switzerland, extracts of Chelidoni herba are a controversial component of the gastric remedy "Iberogast". The OTC-preparation is a top-selling product for the company Bayer, which is now under investigation for not warning consumers from possible hepatotoxic side-effects when taking the drug. Elevated liver-enzymes and toxic hepatitis with a documented fatality have been reported. [26] [27]
The plant is poisonous to chickens. [28]
The aerial parts and roots of greater celandine are used in herbalism. The above-ground parts are gathered during the flowering season and dried at high temperatures. The root is harvested in autumn between August and October and dried. The fresh rhizome is also used. Celandine has a hot and bitter taste. Preparations are made from alcoholic and hot aqueous extractions. The related plant bloodroot has similar chemical composition and uses as greater celandine.
As far back as Pliny the Elder and Dioscorides (1st century CE) this herb has been recognized as a useful detoxifying agent. The root has been chewed to relieve toothache. [29] John Gerard's Herball (1597) states that "the juice of the herbe is good to sharpen the sight, for it cleanseth and consumeth away slimie things that cleave about the ball of the eye and hinder the sight and especially being boiled with honey in a brasen vessell." [30]
It was formerly used by some Romani people as a foot refresher; modern herbalists use its purgative properties. [31] The modern herbalist Juliette de Baïracli Levy recommended greater celandine diluted with milk for the eyes and the latex for getting rid of warts. [32] Chelidonium was a favourite herb of the French herbalist Maurice Mességué. Chelidonium majus has traditionally been used for treatment of various inflammatory diseases including atopic dermatitis. [33] It is also traditionally used in the treatment of gallstones and dyspepsia. [34]
The Iroquois give an infusion of whole plant, another plant and milk to pigs that drool and have sudden movements. [35] [ clarification needed ]
It was also once used to treat liver disorders, owing to the juice's resemblance to bile. [28]
Ficaria verna, commonly known as lesser celandine or pilewort, is a low-growing, hairless perennial flowering plant in the buttercup family Ranunculaceae. It has fleshy dark green, heart-shaped leaves and distinctive flowers with bright yellow, glossy petals. Native to Europe and Western Asia, it is now introduced in North America, where it is known by the common name fig buttercup and considered an invasive species. The plant is poisonous if ingested raw and potentially fatal to grazing animals and livestock such as horses, cattle, and sheep. For these reasons, several US states have banned the plant or listed it as a noxious weed. It prefers bare, damp ground and is considered by horticulturalists in the United Kingdom as a persistent garden weed; nevertheless, many specialist plantsmen, nursery owners and discerning gardeners in the UK and Europe collect selected cultivars of the plant, including bronze-leaved and double-flowered ones. Emerging in late winter with flowers appearing late February through May in the UK, its appearance across the landscape is regarded by many as a harbinger of spring.
Goldenseal, also called orangeroot or yellow puccoon, is a perennial herb in the buttercup family Ranunculaceae, native to North America. It may be distinguished by its thick, yellow knotted rootstock. The stem is purplish and hairy above ground and yellow below ground where it connects to the yellow rhizome. Goldenseal reproduces both clonally through the rhizome and sexually, with clonal division more frequent than asexual reproduction. It takes between 4 and 5 years for a plant to reach sexual maturity, i.e. the point at which it produces flowers. Plants in the first stage, when the seed erupts and cotyledons emerge, can remain in this state one or more years. The second vegetative stage occurs during years two and three and is characterized by the development of a single leaf and absence of a well developed stem. Finally, the third stage is reproductive, at which point flowering and fruiting occurs. This last stage takes between 4 and 5 years to develop.
Actaea racemosa, the black cohosh, black bugbane, black snakeroot, rattle-top, or fairy candle, is a species of flowering plant of the family Ranunculaceae. It is native to eastern North America from the extreme south of Ontario to central Georgia, and west to Missouri and Arkansas. It grows in a variety of woodland habitats, and is often found in small woodland openings.
Herbal medicine is the study of pharmacognosy and the use of medicinal plants, which are a basis of traditional medicine. With worldwide research into pharmacology, some herbal medicines have been translated into modern remedies, such as the anti-malarial group of drugs called artemisinin isolated from Artemisia annua, a herb that was known in Chinese medicine to treat fever. There is limited scientific evidence for the safety and efficacy of many plants used in 21st-century herbalism, which generally does not provide standards for purity or dosage. The scope of herbal medicine sometimes includes fungal and bee products, as well as minerals, shells and certain animal parts.
Solanum dulcamara is a species of vine in the genus Solanum of the family Solanaceae. Common names include bittersweet, bittersweet nightshade, bitter nightshade, blue bindweed, Amara Dulcis, climbing nightshade, felonwort, fellenwort, felonwood, poisonberry, poisonflower, scarlet berry, snakeberry, trailing bittersweet, trailing nightshade, violet bloom, and woody nightshade.
Borage, also known as starflower, is an annual herb in the flowering plant family Boraginaceae native to the Mediterranean region. Although the plant contains small amounts of pyrrolizidine alkaloids, some parts are edible and its seeds provide oil.
Medicinal plants, also called medicinal herbs, have been discovered and used in traditional medicine practices since prehistoric times. Plants synthesize hundreds of chemical compounds for various functions, including defense and protection against insects, fungi, diseases, and herbivorous mammals.
The Papaveraceae, informally known as the poppy family, are an economically important family of about 42 genera and approximately 775 known species of flowering plants in the order Ranunculales. The family is cosmopolitan, occurring in temperate and subtropical climates like Eastern Asia as well as California in North America. It is almost unknown in the tropics. Most are herbaceous plants, but a few are shrubs and small trees. The family currently includes two groups that have been considered to be separate families: Fumariaceae and Pteridophyllaceae. Papaver is the classical name for poppy in Latin.
An eschar is a slough or piece of dead tissue that is cast off from the surface of the skin, particularly after a burn injury, but also seen in gangrene, ulcer, fungal infections, necrotizing spider bite wounds, tick bites associated with spotted fevers and exposure to cutaneous anthrax. The term ‘eschar’ is not interchangeable with ‘scab’. An eschar contains necrotic tissue whereas a scab is composed of dried blood and exudate.
Sanguinaria canadensis, bloodroot, is a perennial, herbaceous flowering plant native to eastern North America. It is the only species in the genus Sanguinaria, included in the poppy family Papaveraceae, and is most closely related to Eomecon of eastern Asia.
Argemone mexicana, also known by the common names Mexican poppy, Mexican prickly poppy, flowering thistle, cardo, and cardosanto, is a species of poppy found in Mexico and now widely naturalized in many parts of the world. An extremely hardy pioneer plant, it is tolerant of drought and poor soil, often being the only cover on new road cuttings or verges. It has bright yellow latex. It is poisonous to grazing animals, and it is rarely eaten, but it has been used medicinally by many peoples, including those in its native area, as well as the indigenous peoples of the western United States, parts of Mexico, and many parts of India. In India, during the colorful festival Holika Dahan, adults and children worship by offering flowers, and this species is in its maximum flowering phase during March when the Holi festival is celebrated. It is also referred to as "kateli ka phool" in India.
Elaiosomes are fleshy structures that are attached to the seeds of many plant species. The elaiosome is rich in lipids and proteins, and may be variously shaped. Many plants have elaiosomes that attract ants, which take the seed to their nest and feed the elaiosome to their larvae. After the larvae have consumed the elaiosome, the ants take the seed to their waste disposal area, which is rich in nutrients from the ant frass and dead bodies, where the seeds germinate. This type of seed dispersal is termed myrmecochory from the Greek "ant" (myrmex) and "circular dance" (khoreíā). This type of symbiotic relationship appears to be mutualistic, more specifically dispersive mutualism according to Ricklefs, R.E. (2001), as the plant benefits because its seeds are dispersed to favorable germination sites, and also because it is planted by the ants.
Sanguinarine is a polycyclic quaternary alkaloid. It is extracted from some plants, including the bloodroot plant, from whose scientific name, Sanguinaria canadensis, its name is derived; the Mexican prickly poppy ; Chelidonium majus; and Macleaya cordata.
Chelerythrine is a benzophenanthridine alkaloid present in the plant Chelidonium majus. It is a potent, selective, and cell-permeable protein kinase C inhibitor in vitro. And an efficacious antagonist of G-protein-coupled CB1 receptors. This molecule also exhibits anticancer qualities and it has served as a base for many potential novel drugs against cancer. Structurally, this molecule has two distinct conformations, one being a positively charged iminium form, and the other being an uncharged form, a pseudo-base.
Fumaria officinalis, the common fumitory, drug fumitory or earth smoke, is a herbaceous annual flowering plant in the poppy family Papaveraceae. It is the most common species of the genus Fumaria in Western and Central Europe.
Pyrrolizidine alkaloids (PAs), sometimes referred to as necine bases, are a group of naturally occurring alkaloids based on the structure of pyrrolizidine. Their use dates back centuries and is intertwined with the discovery, understanding, and eventual recognition of their toxicity on humans and animals.
Symphytum officinale is a perennial flowering plant in the family Boraginaceae. Along with thirty four other species of Symphytum, it is known as comfrey. Internal or long-term topical use of comfrey is discouraged due to its strong potential to cause liver toxicity.
Alstonia constricta, commonly known as quinine bush or bitterbark, is an Australian endemic shrub or small tree of the family Apocynaceae.
Chelidonine is an isolate of Papaveraceae with acetylcholinesterase and butyrylcholinesterase inhibitory activity.