Cornus officinalis | |
---|---|
Scientific classification | |
Kingdom: | Plantae |
Clade: | Tracheophytes |
Clade: | Angiosperms |
Clade: | Eudicots |
Clade: | Asterids |
Order: | Cornales |
Family: | Cornaceae |
Genus: | Cornus |
Subgenus: | Cornus subg. Cornus |
Species: | C. officinalis |
Binomial name | |
Cornus officinalis | |
Cornus officinalis, the Japanese cornel or Japanese cornelian cherry, [1] is a species of flowering plant in the dogwood family Cornaceae. Despite its name, it is native to China and Korea as well as Japan. [2] It is not to be confused with C. mas , which is also known as the Cornelian cherry. It is not closely related to the true cherries of the genus Prunus .
It is a large, strongly-growing deciduous shrub with rough flaky bark. Umbels of acid yellow flowers appear in early spring before the oval leaves. The red berries, which are edible, appear later in the summer, and the leaves turn shades of red before falling in the autumn. [3]
In Korean it is known as sansuyu (산수유), in Chinese as shān zhū yú (山茱萸) and in Japanese as sanshuyu (さんしゅゆ).
The Latin specific epithet officinalis refers to plants which have some medicinal or culinary use - in this case the edible berries. [4]
The plant is valued in cultivation for providing year-round interest in the garden. It is, however, quite a substantial shrub, typically growing to 8 m (26 ft) tall and broad. The cultivar 'Kintoki', with larger and more abundant flowers, has won the Royal Horticultural Society's Award of Garden Merit. [5] [6]
It occurs in China, Japan and Korea where it is used as a food plant and as a medicinal plant.
The plant contains oleanolic acid and ursolic acid. [7] Ursolic acid has shown in vitro protective effects on auditory cells. [8]
Ethanolic extracts of the fruit of C. officinalis has been shown to prevent hepatic injuries associated with acetaminophen-induced liver injury-induced hepatotoxicity (in mice) by preventing or alleviating oxidative stress. [9]
The chemical constituents isolated from the fruit (Corni fructus) have protective effects on beta cells in vitro , [10] [11] and may control postprandial hyperglycemia by alpha-glucosidase inhibition. [12]
Cornel iridoid glycoside, a chemical extracted from Cornus officinalis, promoted neurogenesis and angiogenesis and improved neurological function after ischemia in rats. [13]
Morroniside, the most abundant iridoid glycoside extracted from Cornus officinalis, substantially reduces osteophyte formation and subchondral sclerosis in mice models. Specifically, morroniside significantly promotes cartilage matrix synthesis by increasing collagen type II expression and suppressing chondrocyte pyroptosis. It inhibits matrix metalloproteinase-13 (MMP13), Caspase-1 and nod-like receptor protein-3 (NLRP3) expression in DMM mice and IL-1β-stimulated chondrocytes, and enhances chondrocyte proliferation and inhibits chondrocyte apoptosis. [14] It also slows OA progression by inhibiting nuclear factor-κB (NF-κB) signaling. [15]
A randomized, double-blinded, placebo-controlled study found that a Chinese herbal formula that mainly consisted of Cornus officinalis was not only effective at improving erectile function, but it was also safe for the treatment of erectile dysfunction. [16] A chemical substance isolated from Cornus officinalis also may enhance the motility of human sperm. [17]
Cell cultures of C. officinalis contain gallotannins in the forms of tri-, tetra- and pentagalloylglucoses. The main tannins are 1,2,3,6-tetragalloylglucose, 1,2,6-trigalloyl-glucose, 1,2,3,4,6-pentagalloyl-glucose and 6-digalloyl-1,2,3-trigalloyl-glucose. [18]
Cornelian cherry juices are rich in potassium, calcium, sodium, iron, zinc, manganese, and copper. Compared to other juices obtained from plum, pear, and apple, Cornelian cherry juice contained higher levels of dietary minerals. [19]
Salvia rosmarinus, commonly known as rosemary, is a shrub with fragrant, evergreen, needle-like leaves and white, pink, purple, or blue flowers. It is native to the Mediterranean region, as well as Portugal and Spain. Until 2017, it was known by the scientific name Rosmarinus officinalis, now a synonym.
Cornus is a genus of about 30–60 species of woody plants in the family Cornaceae, commonly known as dogwoods or cornels, which can generally be distinguished by their blossoms, berries, and distinctive bark. Most are deciduous trees or shrubs, but a few species are nearly herbaceous perennial subshrubs, and some species are evergreen. Several species have small heads of inconspicuous flowers surrounded by an involucre of large, typically white petal-like bracts, while others have more open clusters of petal-bearing flowers. The various species of dogwood are native throughout much of temperate and boreal Eurasia and North America, with China, Japan, and the southeastern United States being particularly rich in native species.
Lonicera japonica, known as Japanese honeysuckle and golden-and-silver honeysuckle, is a species of honeysuckle native to East Asia, including many parts of China. It is often grown as an ornamental plant, but has become an invasive species in a number of countries. It is used in traditional Chinese medicine.
Ipomoea tricolor, the Mexican morning glory or just morning glory, is a species of flowering plant in the family Convolvulaceae, native to the tropics of the Americas, and widely cultivated and naturalised elsewhere.
Hydrangea macrophylla is a species of flowering plant in the family Hydrangeaceae, native to Japan. It is a deciduous shrub growing to 2 m (7 ft) tall by 2.5 m (8 ft) broad with large heads of pink or blue flowers in summer and autumn. Common names include bigleaf hydrangea, French hydrangea, lacecap hydrangea, mophead hydrangea, and hortensia. It is widely cultivated in many parts of the world in many climates. It is not to be confused with H. aspera 'Macrophylla'.
Rosa gallica, the Gallic rose, French rose, or rose of Provins, is a species of flowering plant in the rose family, native to southern and central Europe eastwards to Turkey and the Caucasus. Rosa gallica was one of the first species of rose to be cultivated in central Europe. It is a parent of several important cultivars.
Cornus mas, commonly known as cornel, is a species of shrub or small tree in the dogwood family Cornaceae native to Western Europe, Southern Europe, and Southwestern Asia.
Verbena officinalis, the common vervain or common verbena, is a perennial herb native to Europe. It grows up to 70 cm (28 in) high, with an upright habitus. The lobed leaves are toothed, and the delicate spikes hold clusters of two-lipped mauve flowers.
Paeonia lactiflora is a species of herbaceous perennial flowering plant in the family Paeoniaceae, native to central and eastern Asia from eastern Tibet across northern China to eastern Siberia.
Sanguisorba officinalis, commonly known as great burnet, is a plant in the family Rosaceae, subfamily Rosoideae. It is native throughout the cooler regions of the Northern Hemisphere in Europe, northern Asia, and northern North America.
Betulinic acid is a naturally occurring pentacyclic triterpenoid which has antiretroviral, antimalarial, and anti-inflammatory properties, as well as a more recently discovered potential as an anticancer agent, by inhibition of topoisomerase. It is found in the bark of several species of plants, principally the white birch from which it gets its name, same as the bracket fungus Fomitopsis betulina, but also the ber tree, selfheal, the tropical carnivorous plants Triphyophyllum peltatum and Ancistrocladus heyneanus, Diospyros leucomelas, a member of the persimmon family, Tetracera boiviniana, the jambul, flowering quince, rosemary, and Pulsatilla chinensis.
Ursolic acid, is a pentacyclic triterpenoid identified in the epicuticular waxes of apples as early as 1920 and widely found in the peels of fruits, as well as in herbs and spices like rosemary and thyme.
Oleanolic acid or oleanic acid is a naturally occurring pentacyclic triterpenoid related to betulinic acid. It is widely distributed in food and plants where it exists as a free acid or as an aglycone of triterpenoid saponins.
Catalpol is an iridoid glucoside. This natural product falls in the class of iridoid glycosides, which are simply monoterpenes with a glucose molecule attached.
Aucubin is an iridoid glycoside. Iridoids are commonly found in plants and function as defensive compounds. Iridoids decrease the growth rates of many generalist herbivores.
Deacetylasperulosidic acid is an iridoid compound found in a few medicinal plants, such as Morinda citrifolia. Some in vitro and in vivo bioactivities of deacetylasperulosidic acid include anti-inflammatory, analgesic, anti-cancer, antioxidant, anti-arthritic, anti-mutagenic, anti-clastogenic, and hepatoprotection.
Verbascoside is a polyphenol glycoside in which the phenylpropanoid caffeic acid and the phenylethanoid hydroxytyrosol form an ester and an ether bond respectively, to the rhamnose part of a disaccharide, namely β-(3′,4′-dihydroxyphenyl)ethyl-O-α-L-rhamnopyranosyl(1→3)-β-D-(4-O-caffeoyl)-glucopyranoside.
Catechin-7-O-glucoside is a flavan-3-ol glycoside formed from catechin.
Saururus chinensis, commonly known as Asian lizard's tail, is an herb that grows in low, damp places to more than 1 meter high, endemic to China, India, Japan, Korea, Philippines, and Vietnam. Its leaves are green, papery, ribbed, densely glandular, and ovate to ovate-lanceolate, and (4-)10-20 × (2-)5-10 cm in size. Each flower spike resembles a lizard's tail.
Phlomoides tuberosa, the sage-leaf mullein, is a perennial herbaceous flowering plant in the family Lamiaceae, native to China, Kazakhstan, Kyrgyzstan, Mongolia, Russia; SW Asia and Europe. Enlarged, tuberous roots give rise to erect stems to 150 cm bearing purple-red flowers.