Glycochenodeoxycholate sulfotransferase

Glycochenodeoxycholate sulfotransferase
Identifiers
EC no.	2.8.2.34
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
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In enzymology, a glycochenodeoxycholate sulfotransferase (EC 2.8.2.34) is an enzyme that catalyzes the chemical reaction

3'-phosphoadenylyl sulfate + glycochenodeoxycholate ${\displaystyle \rightleftharpoons }$ adenosine 3',5'-bisphosphate + glycochenodeoxycholate 7-sulfate

Thus, the two substrates of this enzyme are 3'-phosphoadenylyl sulfate and glycochenodeoxycholate, whereas its two products are adenosine 3',5'-bisphosphate and glycochenodeoxycholate 7-sulfate.

Nomenclature

This enzyme belongs to the family of transferases, specifically the sulfotransferases, which transfer sulfur-containing groups. The systematic name of this enzyme class is 3'-phosphoadenylyl-sulfate:glycochenodeoxycholate 7-sulfotransferase. Other names in common use include bile acid:3'-phosphoadenosine-5'-phosphosulfate sulfotransferase, bile acid:PAPS:sulfotransferase, and BAST.

Further reading

• Barnes S, Burhol PG, Zander R, Haggstrom G, Settine RL, Hirschowitz BI (November 1979). "Enzymatic sulfation of glycochenodeoxycholic acid by tissue fractions from adult hamsters". Journal of Lipid Research. 20 (8): 952–9. doi:10.1016/S0022-2275(20)39996-X. PMID   533830.
• Russell DW (2003). "The enzymes, regulation, and genetics of bile acid synthesis". Annual Review of Biochemistry. 72: 137–74. doi:10.1146/annurev.biochem.72.121801.161712. PMID   12543708.