In enzymology, an amine sulfotransferase is an enzyme that catalyzes the chemical reaction
An aryl sulfotransferase is an enzyme that transfers a sulfate group from phenolic sulfate esters to a phenolic acceptor substrate.
In enzymology, a chondroitin 4-sulfotransferase is an enzyme that catalyzes the chemical reaction
In enzymology, a chondroitin 6-sulfotransferase is an enzyme that catalyzes the chemical reaction
In enzymology, a cortisol sulfotransferase is an enzyme that catalyzes the chemical reaction
In enzymology, a desulfoglucosinolate sulfotransferase is an enzyme that catalyzes the chemical reaction
Estrone sulfotransferase (EST), also known as estrogen sulfotransferase, is an enzyme that catalyzes the transformation of an unconjugated estrogen like estrone into a sulfated estrogen like estrone sulfate. It is a steroid sulfotransferase and belongs to the family of transferases, to be specific, the sulfotransferases, which transfer sulfur-containing groups. This enzyme participates in androgen and estrogen metabolism and sulfur metabolism.
In enzymology, a galactosylceramide sulfotransferase is an enzyme that catalyzes the chemical reaction
In enzymology, a [heparan sulfate]-glucosamine 3-sulfotransferase 3 is an enzyme that catalyzes the chemical reaction
In enzymology, a [heparan sulfate]-glucosamine N-sulfotransferase is an enzyme that catalyzes the chemical reaction
In enzymology, a petromyzonol sulfotransferase is an enzyme that catalyzes the chemical reaction
In enzymology, a quercetin-3-sulfate 3'-sulfotransferase is an enzyme that catalyzes the chemical reaction
In enzymology, a quercetin-3-sulfate 4'-sulfotransferase is an enzyme that catalyzes the chemical reaction
In enzymology, a Renilla-luciferin sulfotransferase is an enzyme that catalyzes the chemical reaction
In enzymology, a steroid sulfotransferase is an enzyme that catalyzes the chemical reaction
In enzymology, a tyrosine-ester sulfotransferase is an enzyme that catalyzes the chemical reaction
Sulfotransferase 1A1 is an enzyme that in humans is encoded by the SULT1A1 gene.
Sulfotransferase 1A2 is an enzyme that in humans is encoded by the SULT1A2 gene.
Sulfotransferase 1C2 is an enzyme that in humans is encoded by the SULT1C2 gene.
Phenol sulfur transferase deficiency, in short PST deficiency, is the lack or the reduced activity of the functional enzyme phenol sulfur transferase, which is crucial in the detoxification of mainly phenolic compounds by catalysing the sulfate conjugation of the hydroxyl groups in the toxic phenolic compounds to result in more hydrophilic forms for more efficient excretion. This metabolic disorder was first discovered in the late 1990s by Dr. Rosemary Waring during her researches with autistic children, which also made this deficiency commonly associated to the topics of autism. Mutations in the PST genes account for the genetic causes of the deficiency, of which single nucleotide polymorphism and methylation of promoters are two examples of mutations that respectively cause conformational abnormalities and diminished expressions to the enzyme, resulting in the reduced detoxification of phenolic compounds and regulation of phenolic neurotransmitter. The deficiency may cause symptoms like flushing, tachycardia, and depression, and be a risk factor for disorders like autism, migraine, and cancer, while it also limits the use of phenolic drugs in PST deficient patients. There is currently no drug available for treating PST deficiency. However, some people suffering from PST deficiency have found taking a digestive enzyme supplement containing Xylanase 10 minutes before eating to greatly reduce symptoms.
