Scymnol sulfotransferase

Scymnol sulfotransferase
Identifiers
EC no.	2.8.2.32
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
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In enzymology, a scymnol sulfotransferase (EC 2.8.2.32) is an enzyme that catalyzes the chemical reaction

3'-Phosphoadenosine-5'-phosphosulfate + 5beta-scymnol ${\displaystyle \rightleftharpoons }$ adenosine 3',5'-bisphosphate + 5beta-scymnol sulfate

Thus, the two substrates of this enzyme are 3'-Phosphoadenosine-5'-phosphosulfate and 5beta-Scymnol, whereas its two products are adenosine 3',5'-bisphosphate and 5beta-scymnol sulfate.

This enzyme belongs to the family of transferases, specifically the sulfotransferases, which transfer sulfur-containing groups. The systematic name of this enzyme class is 3'-Phosphoadenosine-5'-phosphosulfate:5beta-scymnol sulfotransferase.

References

• Macrides TA, Faktor DA, Kalafatis N, Amiet RG (1994). "Enzymic sulfation of bile salts. Partial purification and characterization of an enzyme from the liver of the shark Heterodontus portusjacksoni that catalyses the sulfation of the shark bile steroid 5 beta-scymnol". Comp. Biochem. Physiol. B. 107 (3): 461–9. doi:10.1016/0305-0491(94)90212-7. PMID   7749614.
• Pettigrew NE, Wright PF, Macrides TA (1998). "Investigation of 5beta-scymnol sulfotransferase from the kidney and testes of Heterodontus portusjacksoni". Comp. Biochem. Physiol. 121 (3): 243–249. doi:10.1016/S0305-0491(98)10097-4.
• Pettigrew NE, Wright PF, Macrides TA (1998). "5beta-Scymnol sulfotransferase isolated from the tissues of an Australian shark species". Comp. Biochem. Physiol. 121 (3): 299–307. doi:10.1016/S0305-0491(98)10103-7.
• Pettigrew NE, Wright PF, Macrides TA (1998). "5beta-scymnol sulfotransferase isolated from the liver of two Australian ray species". Comp. Biochem. Physiol. 121: 341–348. doi:10.1016/S0305-0491(98)10116-5.