Glycyl endopeptidase

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Glycyl endopeptidase
Identifiers
EC no. 3.4.22.25
CAS no. 149719-24-4
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Glycyl endopeptidase (EC 3.4.22.25, papaya peptidase B, papaya proteinase IV, glycine-specific proteinase, chymopapain , Papaya proteinase 4, PPIV, chymopapain M) is an enzyme. [1] [2] [3] [4] [5] This enzyme catalyses the following chemical reaction

Preferential cleavage: Gly-, in proteins and small molecule substrates

This enzyme is isolated from the papaya plant, Carica papaya .

References

  1. ↑ Polgár L (April 1981). "Isolation of highly active papaya peptidases A and B from commercial chymopapain". Biochimica et Biophysica Acta (BBA) - Enzymology. 658 (2): 262–9. doi:10.1016/0005-2744(81)90296-5. PMID   7018581.
  2. ↑ Buttle DJ, Kembhavi AA, Sharp SL, Shute RE, Rich DH, Barrett AJ (July 1989). "Affinity purification of the novel cysteine proteinase papaya proteinase IV, and papain from papaya latex". The Biochemical Journal. 261 (2): 469–76. doi:10.1042/bj2610469. PMC   1138849 . PMID   2505761.
  3. ↑ Ritonja A, Buttle DJ, Rawlings ND, Turk V, Barrett AJ (November 1989). "Papaya proteinase IV amino acid sequence". FEBS Letters. 258 (1): 109–12. Bibcode:1989FEBSL.258..109R. doi: 10.1016/0014-5793(89)81627-8 . PMID   2591528.
  4. ↑ Buttle DJ, Ritonja A, Pearl LH, Turk V, Barrett AJ (January 1990). "Selective cleavage of glycyl bonds by papaya proteinase IV". FEBS Letters. 260 (2): 195–7. Bibcode:1990FEBSL.260..195B. doi: 10.1016/0014-5793(90)80101-n . PMID   2404797.
  5. ↑ Buttle DJ, Ritonja A, Dando PM, Abrahamson M, Shaw EN, Wikstrom P, Turk V, Barrett AJ (March 1990). "Interactions of papaya proteinase IV with inhibitors". FEBS Letters. 262 (1): 58–60. Bibcode:1990FEBSL.262...58B. doi: 10.1016/0014-5793(90)80153-a . PMID   1690669.
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