MK-886

MK-886

Names
Preferred IUPAC name 3-{3-(tert-Butylsulfanyl)-1-[(4-chlorophenyl)methyl]-5-(propan-2-yl)-1H-indol-2-yl}-2,2-dimethylpropanoic acid
Other names L-663536
Identifiers
CAS Number	118414-82-7  Y
3D model (JSmol)	Interactive image
ChEBI	CHEBI:75390
ChEMBL	ChEMBL29097
ChemSpider	2885052
DrugBank	DB16739
MeSH	L+663536
PubChem CID	3651377
UNII	080626SQ8C  Y
CompTox Dashboard (EPA)	DTXSID5041067
InChI InChI=1S/C27H34ClNO2S/c1-17(2)19-10-13-22-21(14-19)24(32-26(3,4)5)23(15-27(6,7)25(30)31)29(22)16-18-8-11-20(28)12-9-18/h8-14,17H,15-16H2,1-7H3,(H,30,31) Key: QAOAOVKBIIKRNL-UHFFFAOYSA-N
SMILES CC(C)C1=CC2=C(C=C1)N(C(=C2SC(C)(C)C)CC(C)(C)C(=O)O)CC3=CC=C(C=C3)Cl
Properties
Chemical formula	C27H34ClNO2S
Molar mass	472.083
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa). Y  verify  (what is  YN ?) Infobox references

MK-886, or L-663536, is a leukotriene antagonist. It may perform this by blocking the 5-lipoxygenase activating protein (FLAP), thus inhibiting 5-lipoxygenase (5-LOX), ^[1] and may help in treating atherosclerosis. ^[2]

References

1. Jun, Joon-Il; Lau, Lester F. (July 2010). "The matricellular protein CCN1 induces fibroblast senescence and restricts fibrosis in cutaneous wound healing". Nature Cell Biology. 12 (7): 676–685. doi:10.1038/ncb2070. ISSN   1465-7392. PMC   2919364 . PMID   20526329.
2. Jawien, J.; Gajda, M.; Rudling, M.; Mateuszuk, L.; Olszanecki, R.; Guzik, T. J.; Cichocki, T.; Chlopicki, S.; Korbut, R. (March 2006). "Inhibition of five lipoxygenase activating protein (FLAP) by MK-886 decreases atherosclerosis in apoE/LDLR-double knockout mice". European Journal of Clinical Investigation. 36 (3): 141–146. doi:10.1111/j.1365-2362.2006.01606.x. PMID   16506957. S2CID   44897529.