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| ECHA InfoCard | 100.233.314 |
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| Formula | C21H16FNO3S |
| Molar mass | 381.42 g·mol−1 |
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Netoglitazone (also called MCC-555) is a hypoglycemic agent belonging to the thiazolidinedione group. [1]
A bone is a rigid organ that constitutes part of the skeleton in most vertebrate animals. Bones protect the various other organs of the body, produce red and white blood cells, store minerals, provide structure and support for the body, and enable mobility. Bones come in a variety of shapes and sizes and have complex internal and external structures. They are lightweight yet strong and hard and serve multiple functions.
Osteoporosis is a systemic skeletal disorder characterized by low bone mass, micro-architectural deterioration of bone tissue leading to more porous bone, and consequent increase in fracture risk.
A skeleton is the structural frame that supports the body of most animals. There are several types of skeletons, including the exoskeleton, which is a rigid outer shell that holds up an organism's shape; the endoskeleton, a rigid internal frame to which the organs and soft tissues attach; and the hydroskeleton, a flexible internal structure supported by the hydrostatic pressure of body fluids.
The human skeleton is the internal framework of the human body. It is composed of around 270 bones at birth – this total decreases to around 206 bones by adulthood after some bones get fused together. The bone mass in the skeleton makes up about 14% of the total body weight and reaches maximum mass between the ages of 25 and 30. The human skeleton can be divided into the axial skeleton and the appendicular skeleton. The axial skeleton is formed by the vertebral column, the rib cage, the skull and other associated bones. The appendicular skeleton, which is attached to the axial skeleton, is formed by the shoulder girdle, the pelvic girdle and the bones of the upper and lower limbs.
The skull is a bone protective cavity for the brain. The skull is composed of three types of bone: cranial bones, facial bones, and ear ossicles. Two parts are more prominent: the cranium and the mandible. In humans, these two parts are the neurocranium (braincase) and the viscerocranium that includes the mandible as its largest bone. The skull forms the anterior-most portion of the skeleton and is a product of cephalisation—housing the brain, and several sensory structures such as the eyes, ears, nose, and mouth. In humans, these sensory structures are part of the facial skeleton.
Skull and Bones, also known as The Order, Order 322 or The Brotherhood of Death, is an undergraduate senior secret student society at Yale University in New Haven, Connecticut. The oldest senior-class society at the university, Skull and Bones has become a cultural institution known for its powerful alumni and conspiracy theories.
The clavicle, collarbone, or keybone is a slender, S-shaped long bone approximately 6 inches (15 cm) long that serves as a strut between the shoulder blade and the sternum (breastbone). There are two clavicles, one on the left and one on the right. The clavicle is the only long bone in the body that lies horizontally. Together with the shoulder blade, it makes up the shoulder girdle. It is a palpable bone and, in people who have less fat in this region, the location of the bone is clearly visible. It receives its name from Latin clavicula 'little key' because the bone rotates along its axis like a key when the shoulder is abducted. The clavicle is the most commonly fractured bone. It can easily be fractured by impacts to the shoulder from the force of falling on outstretched arms or by a direct hit.
Bone marrow is a semi-solid tissue found within the spongy portions of bones. In birds and mammals, bone marrow is the primary site of new blood cell production. It is composed of hematopoietic cells, marrow adipose tissue, and supportive stromal cells. In adult humans, bone marrow is primarily located in the ribs, vertebrae, sternum, and bones of the pelvis. Bone marrow comprises approximately 5% of total body mass in healthy adult humans, such that a man weighing 73 kg (161 lbs) will have around 3.7 kg (8 lbs) of bone marrow.
In vertebrates, the maxilla is the upper fixed bone of the jaw formed from the fusion of two maxillary bones. In humans, the upper jaw includes the hard palate in the front of the mouth. The two maxillary bones are fused at the intermaxillary suture, forming the anterior nasal spine. This is similar to the mandible, which is also a fusion of two mandibular bones at the mandibular symphysis. The mandible is the movable part of the jaw.
Bone Thugs-n-Harmony is an American hip hop group composed of rappers Bizzy Bone, Wish Bone, Layzie Bone, Krayzie Bone, and Flesh-n-Bone. Formed in 1991 in Cleveland, Ohio, the group signed to fellow American rapper Eazy-E's Ruthless Records in late 1993, on which they debuted with their EP Creepin on ah Come Up the next year. The EP included their breakout hit single "Thuggish Ruggish Bone". In 1995, the group released its second album E. 1999 Eternal, which included hits "1st of tha Month" and "East 1999". Their hit song "Tha Crossroads", a tribute to then-recently deceased mentor Eazy-E, won a Grammy Award in 1997.
The metatarsal bones or metatarsus are a group of five long bones in the midfoot, located between the tarsal bones and the phalanges (toes). Lacking individual names, the metatarsal bones are numbered from the medial side : the first, second, third, fourth, and fifth metatarsal. The metatarsals are analogous to the metacarpal bones of the hand. The lengths of the metatarsal bones in humans are, in descending order, second, third, fourth, fifth, and first. A bovine hind leg has two metatarsals.
Oracle bone script is the oldest attested form of written Chinese, dating to the late 2nd millennium BC. Inscriptions were made by carving characters into oracle bones, usually either the shoulder bones of oxen or the plastrons of turtles. The writings themselves mainly record the results of official divinations carried out on behalf of the Late Shang royal family. These divinations took the form of scapulimancy where the oracle bones were exposed to flames, creating patterns of cracks that were then subjected to interpretation. Both the prompt and interpretation were inscribed on the same piece of bone that had been used for the divination itself.
The human musculoskeletal system is an organ system that gives humans the ability to move using their muscular and skeletal systems. The musculoskeletal system provides form, support, stability, and movement to the body.
A bone fracture is a medical condition in which there is a partial or complete break in the continuity of any bone in the body. In more severe cases, the bone may be broken into several fragments, known as a comminuted fracture. A bone fracture may be the result of high force impact or stress, or a minimal trauma injury as a result of certain medical conditions that weaken the bones, such as osteoporosis, osteopenia, bone cancer, or osteogenesis imperfecta, where the fracture is then properly termed a pathologic fracture.
Avascular necrosis (AVN), also called osteonecrosis or bone infarction, is death of bone tissue due to interruption of the blood supply. Early on, there may be no symptoms. Gradually joint pain may develop, which may limit the person's ability to move. Complications may include collapse of the bone or nearby joint surface.
Bones is an American police procedural drama television series created by Hart Hanson for Fox. It premiered on September 13, 2005, and concluded on March 28, 2017, airing for 246 episodes over 12 seasons. The show is based on forensic anthropology and forensic archaeology, with each episode focusing on a Federal Bureau of Investigation (FBI) case file concerning the mystery behind human remains brought by FBI Special Agent Seeley Booth to Temperance "Bones" Brennan, a forensic anthropologist. It also explores the personal lives of the characters. The rest of the main cast includes Michaela Conlin, T. J. Thyne, Eric Millegan, Jonathan Adams, Tamara Taylor, John Francis Daley, and John Boyd.
Englitazone is a hypoglycemic agent of thiazolidinedione (glitazone) class.
In jawed vertebrates, the mandible, lower jaw, or jawbone is a bone that makes up the lower – and typically more mobile – component of the mouth.
Shadow and Bone is a 2021 American fantasy television series developed by Eric Heisserer for Netflix, starring Jessie Mei Li, Ben Barnes and Archie Renaux, with Freddy Carter, Amita Suman, and Kit Young in supporting roles. Based on the works of Leigh Bardugo, the series is set in the Grishaverse and follows Alina Starkov (Li), an orphan and cartographer who discovers she is a Grisha, someone with magical abilities, and the key to saving her war-torn world.
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