Leukotriene B4 receptor 1

LTB4R
Identifiers
Aliases	LTB4R , BLT1, BLTR, CMKRL1, GPR16, LTB4R1, LTBR1, P2RY7, P2Y7, leukotriene B4 receptor
External IDs	OMIM: 601531; MGI: 1309472; HomoloGene: 22477; GeneCards: LTB4R; OMA:LTB4R - orthologs
Gene location (Human) Chr. Chromosome 14 (human) [1] Band 14q12 Start 24,311,450 bp [1] End 24,318,036 bp [1]
Gene location (Mouse) Chr. Chromosome 14 (mouse) [2] Band 14 C3|14 28.19 cM Start 56,003,419 bp [2] End 56,005,951 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in skin of abdomen blood skin of leg monocyte granulocyte spleen vagina olfactory zone of nasal mucosa bone marrow minor salivary glands Top expressed in granulocyte tibiofemoral joint lip bone marrow skin of external ear jejunum embryo embryo blood esophagus More reference expression data BioGPS n/a
Gene ontology Molecular function nucleotide binding G protein-coupled peptide receptor activity G protein-coupled receptor activity leukotriene receptor activity signal transducer activity leukotriene B4 receptor activity galanin receptor activity Cellular component integral component of membrane membrane raft plasma membrane integral component of plasma membrane membrane Biological process G protein-coupled receptor signaling pathway phospholipase C-activating G protein-coupled receptor signaling pathway leukotriene signaling pathway muscle contraction neuropeptide signaling pathway immune response signal transduction inflammatory response Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 1241 16995 Ensembl ENSG00000213903 ENSG00000285456 ENSMUSG00000046908 UniProt Q15722 O88855 RefSeq (mRNA) NM_181657 NM_001143919 NM_008519 RefSeq (protein) NP_001137391 NP_858043 NP_032545 Location (UCSC) Chr 14: 24.31 – 24.32 Mb Chr 14: 56 – 56.01 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Leukotriene B₄ receptor 1, also known as BLT1 or BLT1 receptor, is a protein that in humans is encoded by the LTB4R gene. ^{[5] [6] [7]}

See also

• Eicosanoid receptor
• Etalocib, an antagonist at the leukotriene B₄ receptor

References

1. ENSG00000285456 GRCh38: Ensembl release 89: ENSG00000213903, ENSG00000285456 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000046908 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Owman C, Nilsson C, Lolait SJ (Feb 1997). "Cloning of cDNA encoding a putative chemoattractant receptor". Genomics. 37 (2): 187–94. doi:10.1006/geno.1996.0541. PMID   8921391.
6. Akbar GK, Dasari VR, Webb TE, Ayyanathan K, Pillarisetti K, Sandhu AK, Athwal RS, Daniel JL, Ashby B, Barnard EA, Kunapuli SP (Sep 1996). "Molecular cloning of a novel P2 purinoceptor from human erythroleukemia cells". J Biol Chem. 271 (31): 18363–7. doi: 10.1074/jbc.271.31.18363 . PMID   8702478.
7. "Entrez Gene: LTB4R leukotriene B4 receptor".

Further reading

• Raport CJ, Schweickart VL, Chantry D, et al. (1996). "New members of the chemokine receptor gene family". J. Leukoc. Biol. 59 (1): 18–23. doi:10.1002/jlb.59.1.18. PMID   8558062. S2CID   24239900.
• Tager AM, Luster AD (2004). "BLT1 and BLT2: the leukotriene B(4) receptors". Prostaglandins Leukot. Essent. Fatty Acids. 69 (2–3): 123–34. doi:10.1016/S0952-3278(03)00073-5. PMID   12895595.
• Miyahara N, Miyahara S, Takeda K, Gelfand EW (2006). "Role of the LTB4/BLT1 pathway in allergen-induced airway hyperresponsiveness and inflammation". Allergology International. 55 (2): 91–7. doi: 10.2332/allergolint.55.91 . PMID   17075244.
• Hillier LD, Lennon G, Becker M, et al. (1997). "Generation and analysis of 280,000 human expressed sequence tags". Genome Res. 6 (9): 807–28. doi: 10.1101/gr.6.9.807 . PMID   8889549.
• Yokomizo T, Izumi T, Chang K, et al. (1997). "A G-protein-coupled receptor for leukotriene B4 that mediates chemotaxis". Nature. 387 (6633): 620–4. Bibcode:1997Natur.387..620Y. doi:10.1038/42506. PMID   9177352. S2CID   4307104.
• Maier R, Glatz A, Mosbacher J, Bilbe G (1997). "Cloning of P2Y6 cDNAs and identification of a pseudogene: comparison of P2Y receptor subtype expression in bone and brain tissues". Biochem. Biophys. Res. Commun. 237 (2): 297–302. doi:10.1006/bbrc.1997.7135. PMID   9268704.
• Gaudreau R, Le Gouill C, Métaoui S, et al. (1998). "Signalling through the leukotriene B4 receptor involves both alphai and alpha16, but not alphaq or alpha11 G-protein subunits". Biochem. J. 335 (1): 15–8. doi:10.1042/bj3350015. PMC   1219746 . PMID   9742207.
• Kato K, Yokomizo T, Izumi T, Shimizu T (2000). "Cell-specific transcriptional regulation of human leukotriene B(4) receptor gene". J. Exp. Med. 192 (3): 413–20. doi:10.1084/jem.192.3.413. PMC   2193224 . PMID   10934229.
• Yokomizo T, Kato K, Terawaki K, et al. (2000). "A second leukotriene B(4) receptor, BLT2. A new therapeutic target in inflammation and immunological disorders". J. Exp. Med. 192 (3): 421–32. doi:10.1084/jem.192.3.421. PMC   2193217 . PMID   10934230.
• Stankova J, Turcotte S, Harris J, Rola-Pleszczynski M (2002). "Modulation of leukotriene B4 receptor-1 expression by dexamethasone: potential mechanism for enhanced neutrophil survival". J. Immunol. 168 (7): 3570–6. doi: 10.4049/jimmunol.168.7.3570 . PMID   11907121.
• Gaudreau R, Le Gouill C, Venne MH, et al. (2002). "Threonine 308 within a putative casein kinase 2 site of the cytoplasmic tail of leukotriene B(4) receptor (BLT1) is crucial for ligand-induced, G-protein-coupled receptor-specific kinase 6-mediated desensitization". J. Biol. Chem. 277 (35): 31567–76. doi: 10.1074/jbc.M202723200 . PMID   12077128.
• Hennig R, Ding XZ, Tong WG, et al. (2002). "5-Lipoxygenase and leukotriene B(4) receptor are expressed in human pancreatic cancers but not in pancreatic ducts in normal tissue". Am. J. Pathol. 161 (2): 421–8. doi:10.1016/S0002-9440(10)64198-3. PMC   1850753 . PMID   12163367.
• Ito N, Yokomizo T, Sasaki T, et al. (2003). "Requirement of phosphatidylinositol 3-kinase activation and calcium influx for leukotriene B4-induced enzyme release". J. Biol. Chem. 277 (47): 44898–904. doi: 10.1074/jbc.M208051200 . PMID   12244116.
• Tong WG, Ding XZ, Hennig R, et al. (2003). "Leukotriene B4 receptor antagonist LY293111 inhibits proliferation and induces apoptosis in human pancreatic cancer cells". Clin. Cancer Res. 8 (10): 3232–42. PMID   12374694.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Yokomizo T, Noiri E, Izumi T, Shimizu T (2003). "In Vivo Chemotaxis Using Cho Cells Expressing Human Leukotriene B4 Receptor". Eicosanoids and Other Bioactive Lipids in Cancer, Inflammation, and Radiation Injury, 5. Advances in Experimental Medicine and Biology. Vol. 507. pp. 357–61. doi:10.1007/978-1-4615-0193-0_55. ISBN   978-1-4613-4960-0. PMID   12664610.

External links

• "Leukotriene Receptors: BLT₁". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology. Archived from the original on 2013-03-14. Retrieved 2008-12-05.
• LTB4R+protein,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
• Receptors,+Leukotriene+B4 at the U.S. National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.