Prokineticin

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Prokineticin 1
2KRA.pdb.jpg
Prokineticin 1 [1]
Identifiers
SymbolPROK1
NCBI gene 84432
HGNC 18454
OMIM 606233
RefSeq NM_032414
UniProt P58294
Other data
Locus Chr. 1 p21
Search for
Structures Swiss-model
Domains InterPro
prokineticin 2
Identifiers
SymbolPROK2
NCBI gene 60675
HGNC 18455
OMIM 607002
RefSeq NM_021935
UniProt Q9HC23
Other data
Locus Chr. 3 p21.1
Search for
Structures Swiss-model
Domains InterPro

Prokineticin is a secreted protein that potently contracts gastrointestinal smooth muscle. [2]

Contents

Recently, prokineticins have been recognized in humans and other vertebrates. [3] They are thought to be involved in several important physiological processes like neurogenesis, tissue development, angiogenesis, and nociception. [3] [4] Other important physiological roles the Bv8/Prokineticins (PKs) are involved in may include cancer, reproduction, and regulating physiological functions that influence circadian rhythms like hormone secretion, ingestive behaviors, and the sleep/wake cycle. [5]

Mutations in the PROK2 (also known as KAL4) gene have been implicated in hypogonadotropic hypogonadism and gynecomastia. [6]

See also

References

  1. ↑ "RCSB Protein Data Bank - Structure Summary for 2KRA - Solution structure of Bv8".
  2. ↑ Li M, Bullock CM, Knauer DJ, Ehlert FJ, Zhou QY (2001). "Identification of two prokineticin cDNAs: recombinant proteins potently contract gastrointestinal smooth muscle". Mol. Pharmacol. 59 (4): 692–8. doi:10.1124/mol.59.4.692. PMID   11259612. S2CID   1597745.
  3. 1 2 Morales RA, Daly NL, Vetter I, et al. (September 2010). "Chemical synthesis and structure of the prokineticin Bv8". ChemBioChem. 11 (13): 1882–8. doi:10.1002/cbic.201000330. PMID   20677202. S2CID   32535956.
  4. ↑ Liu B, Qiao L, Liu K, Piccinni-Ash TJ, Chen ZF. Molecular and neural basis of pleasant touch sensation. Science 2022; 376(6592):483. doi : 10.1126/science.abn2479
  5. ↑ Negri L, Lattanzi R, Giannini E, Melchiorri P (September 2007). "Bv8/Prokineticin proteins and their receptors". Life Sci. 81 (14): 1103–16. doi:10.1016/j.lfs.2007.08.011. PMID   17881008.
  6. ↑ Narula, Harmeet S.; Carlson, Harold E. (2014). "Gynaecomastia—pathophysiology, diagnosis and treatment". Nature Reviews Endocrinology. 10 (11): 684–698. doi:10.1038/nrendo.2014.139. ISSN   1759-5029. PMID   25112235. S2CID   40159424.


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